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| 1 | LC,MS^n and LC-MS/MS studies for the characterization of degradation products of amlodipine显示文摘In the present study,comprehensive stress testing of amlodipine(AM) was carried out according to International Conference on Harmonization(ICH) Q1A(R2) guideline.AM was subjected to acidic,neutral and alkaline hydrolysis,oxidation,photolysis and thermal stress conditions.The drug showed instability in acidic and alkaline conditions,while it remained stable to neutral,oxidative,light and thermal stress.A total of nine degradation products(DPs) were formed from AM.which could be separated by the developed gradient LC method on a C_(18) column.The products formed under various stress conditions were investigated by LC-MS/MS analysis.The previously developed LC method was suitably modified for LC-MS/MS studies by replacing phosphate buffer with ammonium acetate buffer of the same concentration(pH 5.0).A complete fragmentation pathway of the drug was first established to characterize all the degradation products using LC-MS/MS and multi-stage mass(MS^n) fragmentation studies.The obtained mass values were used to study elemental compositions,and the total information helped with the identification of DPs.along with its degradation pathway. | Ravi N.Tiwari Nishit Shah Vikas Bhalani Anand Mahajan | 2015 | Journal of Pharmaceutical Analysis2015，5，1： | 2 |
| 2 | Construction-related differences seen in ureteral access sheaths:comparison of reinforced versus nonreinforced ureteral access sheaths显示文摘 | Shields JM Tunuguntla HS Bhalani VK | 2009 | Urology2009，73，2： | 1 |
| 3 | Clearance of p-cresolsulfate and P-2-microglobulin from dialysate by commerciallyavailable sorbent technology 显示文摘 | KRUSE A TAO X BHALANI V | 2011 | Asaio J2011，57，3： | 1 |
| 4 | Near optimal per- formance joint semi - blind channel estimation and data de- tection techniques for Alamouti coded single - carrier (SC) MIMO communication systems 显示文摘 | Bhalani J K Chauhan D Kosta Y P | 2013 | Physical Communica- tion2013，，8： | 1 |
| 5 | Value of ultra- sonography in laryngeal and laryngopharyngeal cancers显示文摘 | Desai A A Pandya V K Bhalani D B | 2004 | Indian J Otolaryngol Head Neck Surg2004，56，3： | 1 |
| 6 | Construction-related Differences Seen in Ureteral Access Sheaths: Comparison of Reinforced Versus Nonreinforced Ureteral Access Sheaths显示文摘 | John M. Shields Hari S.G.R. Tunuguntla Vishal K. Bhalani Rajnikanth Ayyathurai Vincent G. Bird | 2009 | Urology2009，，： | 1 |
| 7 | Paraganglioma of the bladder显示文摘 | Bhalani SM Casalino DD Manvar AM | 2011 | J Urol2011，186，1： | 1 |
| 8 | The natural history of re-nal stone fragments following ureteroscopy显示文摘 | Rebuck D A Macejko A Bhalani V | 2010 | Urology2010，77，3： | 1 |
| 9 | Development of Fast Dissolving Tablets Containing Fexofenadine Hydrochloride Prepared by Lyophilization Technique显示文摘Objectives: To improve the aqueous solubility and dissolution of fexofenadine HCl, an attempt was made to prepare its fast dissolving tablets by lyophilization technique. Methods: For the preparation of lyophilized tablets (F1-F32), the drug was dispersed in a hydrated solution of water-soluble polymers (gelatin/maltodextrin/acacia) containing glycine and mannitol. The blend was pelted down into the patches of a blister pack, frozen down and then lyophilized. Different characterization parameters viz. differential scanning calorimetry, hardness, weight variation, X-ray diffraction (XRD), scanning electron microscopy (SEM), mercury porosimetry, solubility, wetting time and water absorption ratio, lyophilization tablet index, drug content, in vitro dissolution and stability were evaluated. Key findings: Tablets (F32) containing acacia were found to have fast disintegration and relatively higher mechanical strength with improved drug solubility. X-ray diffractogram and scanning electron micrograph indicated decrease in crystallinity of drug and a good porous structure property for prepared tablet, respectively. Dissolution study showed complete drug released within 5 min. Moreover, tablets (F32) were found to be stable for one month at 25 ± 2 °C/60 ± 5% relative humidity. | Rajendra Kotadiya Bhavin Bhalani | 2019 | Journal of Pharmacy and Pharmacology2019，7，10： | 0 |
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