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| 1 | Autologous bone marrow derived stem cell therapy in patients with type 2 diabetes mellitus-defining adequate administration methods显示文摘AIM To carry out randomized trial for evaluating effects of autologous bone marrow derived stem cell therapy(ABMSCT) through different routes.METHODS Bone marrow aspirate was taken from the iliac crest of patients. Bone marrow mononuclear cells were separatedand purified using centrifugation. These cells were then infused in a total of 21 patients comprising three groups of 7 patients each. Cells were infused into the superior pancreaticoduodenal artery(Group Ⅰ), splenic artery(Group Ⅱ) and through the peripheral intravenous route(Group Ⅲ). Another group of 7 patients acted as controls and a sham procedure was carried out on them(Group Ⅳ). The cells were labelled with the PET tracer F18-FDG to see their homing and in vivo distribution. Data for clinical outcome was expressed as mean ± SE. All other data was expressed as mean ± SD. Baseline and post treatment data was compared at the end of six months, using paired t-test. Cases and controls data were analyzed using independent t-test. A probability(P) value of < 0.05 was regarded as statistically significant. Measures of clinical outcome were taken as the change or improvement in the following parameters:(1) C-peptide assay;(2) HOMA-IR and HOMA-B;(3) reduction in Insulin dose; subjects who showed reduction of insulin requirement of more than 50% from baseline requirement were regarded as responders; and(4) reduction in HbA 1c. RESULTS All the patients, after being advised for healthy lifestyle changes, were evaluated at periodical intervals and at the end of 6 mo. The changes in body weight, body mass index, waist circumference and percentage of body fat in all groups were not significantly different at the end of this period. The results of intra-group comparison before and after ABMSCT at the end of six months duration was as follows:(1) the area under C-peptide response curve was increased at the end of 6 mo however the difference remained statistically non-significant(P values for fasting C-peptide were 0.973, 0.103, 0.263 and 0.287 respectively and the P values for stimulated C-peptide were 0.989, 0.395, 0.325 and 0.408 respectively for groups Ⅰ?to Ⅳ);(2) the Insulin sensitivity indices of HOMA IR and HOMA B also did not show any significant differences(P values for HOMA IR were 0.368, 0.223, 0.918 and 0.895 respectively and P values for HOMA B were 0.183, 0.664, 0.206 and 0.618 respectively for groups Ⅰto Ⅳ);(3) Group Ⅰshowed a significant reduction in Insulin dose requirement(P < 0.01). Group Ⅱ patients also achieved a significant reduction in Insulin dosages(P = 0.01). The Group Ⅰand Group Ⅱ patients together constituted the targeted group wherein the feeding arteries to pancreas were used for infusing stem cells. Group Ⅲ, which was the intravenous group, showed a non-significant reduction in Insulin dose requirement(P = 0.137). Group Ⅳ patients which comprised the control arm also showed a significant reduction in Insulin dosages at the end of six months(P < 0.05); and(4) there was a non-significant change in the Hb A1 c levels at the end of 6 mo across all groups(P = 0.355, P = 0.351, P = 0.999 and P = 0.408 respectively for groups Ⅰto Ⅳ). CONCLUSION Targeted route showed a significant reduction in Insulin requirement at the end of six months of study period whereas the intravenous group failed to show reduction. | Vikas Sood Anil Bhansali Bhagwant Rai Mittal Baljinder Singh Neelam Marwaha Ashish Jain Niranjan Khandelwal | 2017 | World Journal of Diabetes2017，8，7： | 6 |
| 2 | Chronological age when health care transition skills are mastered in adolescents/young adults with inflammatory bowel disease显示文摘AIM To describe the longitudinal course of acquisition of healthcare transition skills among adolescents and young adults with inflammatory bowel diseases.METHODS We recruited adolescents and young adults(AYA) with inflammatory bowel diseases(IBD), from the pediatric IBD clinic at the University of North Carolina. Participants completed the TRx ANSITION Scale? at least once during the study period(2006-2015). We used the electronic medical record to extract participants' clinical and demographic data. We used ordinary least square regressions with robust standard error clustered at patient level to explore the variations in the levels and growths of healthcare transition readiness.RESULTS Our sample(n = 144) ranged in age from 14-22 years. Age was significantly and positively associated with both the level and growth of TRx ANSITION Scale? scores(P < 0.01). Many healthcare transition(HCT) skills were acquired between ages 12 and 14 years, but others were not mastered until after age 18, including self-management skills.CONCLUSION This is one of the first studies to describe the longitudinal course of HCT skill acquisition among AYA with IBD, providing benchmarks for evaluating transition interventions. | Natalie Stollon Yi Zhong Maria Ferris Suneet Bhansali Brian Pitts Eniko Rak Maureen Kelly Sandra Kim Miranda AL van Tilburg | 2017 | World Journal of Gastroenterology2017，23，18： | 2 |
| 3 | Indian patients with nonalcoholic fatty liver disease presenting with raised transaminases are different at presentation显示文摘 | Ajay Duseja Ashim Das Radha Krishan Dhiman Yogesh Kumar Chawla Reena Das Sanjay Bhadada Ravinder Sialy Kiran Kumar Thumburu Anil Bhansali Naveen Kalra | 2007 | World Journal of Gastroenterology2007，13，4： | 2 |
| 4 | Acanthosis nigricans:relation with type 2 diabetes mellitus,anthropometric variables,and body mass in Indians显示文摘 | Grandhe NP Bhansali A Dogra S | 2005 | Postgrad Med J2005，81，958： | 1 |
| 5 | Probing human skin as an information-rich smart biological interface using MEMS sensors显示文摘 | Bhansali S Thurman H Hoath S B | 2002 | Microelectronics Journal2002，33，12： | 1 |
| 6 | Selective seeding of copper films on polyimide-pattemod silicon substrate,using ion implantation显示文摘 | Bhansali S Sood D K | 1996 | Sensors and Actuators1996，52，13： | 1 |
| 7 | Primary adrenal lymphoma 显示文摘 | Dutta P Bhansali A Venkatesan R | 2005 | Endocrinologist2005，15，： | 1 |
| 8 | A novel technique for fabrication of metallic structures on polylmide by selective electrolcss copper plating using ion implantation显示文摘 | Bhansali S Seed D K | 1995 | Thin Solid Films1995，270，12： | 1 |
| 9 | Type 2 diabetes and risk of prostate cancer:a meta analysis of observational stud ies显示文摘 | BANSAL D BHANSALI A KAPIL G et ai | 2013 | Prostate Cancer Prostatic Dis2013，16，： | 1 |
| 10 | Insulin Resistance Is Common in Patients with Predominantly Genotype 3 Chronic Hepatitis C显示文摘 | Ajay Duseja R. K. Dhiman Yogesh Chawla Kiran K. Thumburu Amit Kumar Ashim Das Sanjay Bhadada Anil Bhansali | 2009 | Digestive Diseases and Sciences2009，，8： | 1 |
| 11 | Thyrotoxicosis-surgical management in the era of evidence-based medicine: experience in western India with 752 cases显示文摘 | Bhansali SK Chandalia HB | 2002 | Asian J Surg2002，25，4： | 1 |
| 12 | A pilot study on hypot halamo-pit uitary-adrenocor tical axis in primary hyperparathyroidism显示文摘 | Rajput R Bhansali A Bhadada SK | 2009 | Indian J Med Res2009，130，4： | 1 |
| 13 | Pantoprazole Improves Glycemic Control in Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial显示文摘 | Pawan Kumar Singh Debasish Hota Pinaki Dutta Naresh Sachdeva Amitava Chakrabarti Anand Srinivasan Inderjeet Singh Anil Bhansali | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，11： | 1 |
| 14 | Spectrum ofneurological manifestations of idiopathic hypoparathyroid-ism and pseudohypoparathyroidism 显示文摘 | Bhadada S K Bhansali A Upreti V | 2011 | Neurol India2011，59，4： | 1 |
| 15 | Pattern of recurrence after extended radical esophagectomy with three-field lymph node dissection for squamous cell carcinoma in the thoracic esophagus 显示文摘 | Bhansali MS Fujita H Kakcgawa T | 1997 | World J Surg1997，21，3： | 1 |
| 16 | Effects of three different doses of a fruit extract of Terminalia chebula on metabolic components of metabolic syndrome,in a rat model显示文摘 | Singh I Singh PK Bhansali S | 2010 | Phytother Res2010，24，1： | 1 |
| 17 | Efficacy and safety of autolo- gous bone marrow derived hematopoietic stem cell transplantation in patients with type 2 DM:a 15 months follow-up study 显示文摘 | Bhansali A Upreti V Walia R | 2014 | Indian J Endocrinol Metab2014，18，6： | 1 |
| 18 | Efficacy and safety of autol- ogous bone marrow- derived stem cell transplantation in patients with type 2 diabetes mellitus : a randomized placebo-controlled study 显示文摘 | Bhansali A Asokumar P Walia R | 2014 | Cell Transplant2014，23，9： | 1 |
| 19 | Juvenile hyperthyroidism : An experience 显示文摘 | Bhadada S Bhansali A Velayutham P | 2006 | Indian Pediatr2006，43，4： | 1 |
| 20 | Efficacy of autologous bone marrow-derived stem cell transplantation in patients with type 2 diabetes rnellitus显示文摘 | Bhansali A Upreti V Khandelwal N | 2009 | Stem Ceils Dev2009，18，10： | 1 |
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