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| 1 | Crohn's disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil显示文摘AIM To identify environmental risk factors associated with the development of Crohn's disease(CD) in order to reassess the hygiene hypothesis.METHODS A hospital-based, case-control study was carried out with CD patients(n = 145) and controls(n = 163)representing a socioeconomically diverse statewide catchment area in Brazil. Controls were recruited from caregivers of patients seen in different outpatient clinics at the same hospital. A multi-item survey with 94 questions regarding family history of CD, perinatal and childhood circumstances, living conditions, tobacco use and familial socioeconomic status was carried out by interviewers. RESULTS On the univariate analysis, predictive variables for CD included being male, under age of 40, a high education level, urban dweller, smaller family size, exposure to enteric pathogens and user of treated water(P < 0.005). On the multivariate analysis, variables significantly associated with CD were male gender(OR = 2.09), under age 40(OR = 3.10), white(OR = 2.32), from a small family in childhood(OR = 2.34) and adulthood(OR = 3.02), absence of viral infections in childhood(OR = 2.23), exposure to enteric pathogens(OR = 2.41), having had an appendectomy(OR = 2.47) and prior or current smoker(OR = 2.83/1.12). CONCLUSION Most variables supporting the 'hygiene hypothesis' are associated with the development of CD but are not independent predictors of the diagnosis. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Boechat Bianca C Schorr Isabella S Leao Tiago Nunes Cyrla Zaltman | 2017 | World Journal of Gastroenterology2017，23，30： | 2 |
| 2 | Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12显示文摘 | Birgit Oppmann Robin Lesley Bianca Blom Jackie C Timans Yuming Xu Brisdell Hunte Felix Vega Nancy Yu Jing Wang Komal Singh Francesca Zonin Elena Vaisberg Tatyana Churakova Man-ru Liu Daniel Gorman Janet Wagner Sandra Zurawski Yong-Jun Liu John S Abrams Ke | 2000 | Immunity2000，，5： | 2 |
| 3 | Acetylation of glycerol catalyzed by different solid acids显示文摘 | VALTER L C G BIANCA P P JOAO C S | 2008 | Catalysis Today2008，，133135： | 1 |
| 4 | Insulin-loaded PLGA/cyclodextrin large porous particles with improved aerosolization properties:in vivo deposition and hypoglycaemic activity after delivery to rat lungs显示文摘 | Ungaro F d'Emmanuele di Villa Bianca R Giovino C | 2009 | J Control Release2009，135，1： | 1 |
| 5 | Helical CT finding in patients with hepatocellular carcinoma treated with percutaneous ablation procedures显示文摘 | Orlando C Bianca C Fabio S | 2000 | JACT2000，24，5： | 1 |
| 6 | Proposal for a new self- compiled questionnaire in patients affected by Temporomandibu- lar joint disorders (TMD) 显示文摘 | Agrillo A Ramieri V Bianca C | 2010 | Eur Rev Med Pharmacol Sci2010，14，7： | 1 |
| 7 | Why do employees take more initiatives to improve their performance after co-deveh)ping performance measures? A field study显示文摘 | Bianca A C Marc J F Celeste P M | 2012 | Management ccounting Resem''ch2012，23，2： | 1 |
| 8 | pH-sensitive hydrogel based on a novel photocross-linkable copolymer 显示文摘 | Delia M Giovanna P Fabio S P Bianca C | 2004 | Biomacromolecules2004，5，5： | 1 |
| 9 | Fatigue analysis of damaged steel pipelines under cyclic internal pressure显示文摘 | Bianca de C Pinheiro Ilson P Pasqualino | 2009 | International Journal of Fatigue2009，31，1： | 1 |
| 10 | Fetal upper limb amelia with increased nuchal translucency显示文摘 | Bianca S Bartoloni G Libertini C | 2009 | Congenit Anom (Kyoto)2009，49，3： | 1 |
| 11 | The importance of chitin in the marine environment显示文摘 | Claudiana P Souza Bianca C | 2011 | Marine Biotechnology2011，13，5： | 1 |
| 12 | Patent ductus arteriosus and left coronary ostium stenosis: an hybrid approach 显示文摘 | Agati S Mignosa C Bianca I | 2003 | Interact Cardiovasc Thorac Surg2003，2，3： | 1 |
| 13 | Role of hepatitis B virus in development of hepatocellular carcinoma:Focus on covalently closed circular DNA显示文摘Chronic infection with hepatitis B virus(HBV)remains a major global health problem,especially in developing countries.It may lead to prolonged liver damage,fibrosis,cirrhosis,and hepatocellular carcinoma.Persistent chronic HBV infection is related to host immune response and the stability of the covalently closed circular DNA(cccDNA)in human hepatocytes.In addition to being essential for viral transcription and replication,cccDNA is also suspected to play a role in persistent HBV infections or hepatitis relapses since cccDNA is very stable in non-dividing human hepatocytes.Understanding the pathogenicity and oncogenicity of HBV components would be essential in the development of new diagnostic tools and treatment strategies.This review summarizes the role and molecular mechanisms of HBV cccDNA in hepatocyte transformation and hepatocarcinogenesis and current efforts to its detection and targeting. | Claryssa Bianca Elizabeth Sidhartha Claudio Tiribelli Korri Elvanita El-Khobar Caecilia H C Sukowati | 2022 | World Journal of Hepatology2022，14，5： | 1 |
| 14 | Child home injury prevention:understand- ing the context of unintentional injuries to preschoolchildren显示文摘 | Jean C Bianca L | 2009 | International Journal of Injury Control and Safety Promotion2009，16，3： | 1 |
| 15 | Fetal upper limb ameliawith increased nuchal translucency显示文摘 | Bianca S Bartoloni G Libertini C | | 0，，： | 1 |
| 16 | Successful engraftment of cultured autologous mesenchymal stem ceils in a surgically repaired soft palate defect in an adult horse 显示文摘 | Bianca C Christophe D Mehrak H | 2006 | Can J Vet Res2006，70，2： | 1 |
| 17 | A SolventlessCastor Oil-based PU Adhesive for Wood and Foam Substrates显示文摘 | BIANCA B R S RUTH M C S MARIA M C | 2010 | International Journal of Adhesion and Adhesives2010，，30： | 1 |
| 18 | Heavy metal uptake by barley growing in polluted soils: relationship With heavy metal speciation in soils 显示文摘 | Nicoletta C Bianca M P Massimiliano P | 2002 | Communications in Soil Science and Plant Analysis2002，33，12： | 1 |
| 19 | Acetylation of glycerol catalyzed by different solid acids 显示文摘 | VALTER L C GONCALVES BIANCA P PINTO JOAO C SILVA | 2008 | Catalysis Today2008，，： | 1 |
| 20 | Insulin-loaded PLGA/cyclo- dextrin large porous particles with improved aerosolization proper- ties:In vivo deposition and hypoglycaemic activity after delivery to rat lungs 显示文摘 | Ungaro F Bianca R Giovino C | 2009 | Journal of Controlled Release2009，135，1： | 1 |
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