| 1 | Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy显示文摘Paclitaxel(PTX) is one of the most effective anticancer drugs for the treatment of various solid tumors, but its clinical use is limited by its poor solubility, low bioavailability, and severe systemic toxicity. Encapsulation of PTX in polymeric nanoparticles is used to overcome these problems but these micelles still need improvements in stability, pharmacokinetics, therapeutic efficacy, and safety profiles. In this study, we demonstrate a facile fabrication of a stable PTX-binding micelle made from poly(ethylene glycol)-block-dendritic polylysine, whose primary amines were reacted with phenethyl isothiocyanate(PEITC), a hydrophobic anticancer agent under clinical study. The amphiphilic conjugate(PEG-Gx-PEITC; Gx, the generation of the polylysine dendron) formed well-defined micelles whose core was composed of phenyl groups and thiourea groups binding PTX via π-π stacking and hydrogen bonding. Compared with the PTX-loaded poly(ethylene glycol)-block-poly(D,L-lactide)(PEGPDLLA/PTX) micelles in clinical use, PTX-loaded PEG-Gx-PEITC third-generation(PEG-G3-PEITC/PTX) micelles showed slowed blood clearance, enhanced tumor accumulation, and thus much improved in vivo therapeutic efficacy in both subcutaneous and orthotopic human breast cancer xenografts. Therefore, PEG-G3-PEITC is a promising drug delivery system for PTX in the treatment of breast cancer. | Jiajia Xiang Bihan Wu Zhuxian Zhou Shiqi Hu Ying Piao Quan Zhou Guowei Wang Jianbin Tang Xiangrui Liu Youqing Shen | 2018 | Science China(Life Sciences)2018，61，4： | 6 |
| 2 | Electrocatalytic acidic oxygen evolution reaction:From nanocrystals to single atoms显示文摘Hydrogen is the most preferred choice as an energy source to replace the nonrenewable energy resources such as fossil fuels due to its beneficial features of abundance,ecofriendly,and outstanding gravimetric energy density.Splitting water through a proton exchange membrane(PEM)electrolyzer is a well-known method of hydrogen production.But the major impediment is the sluggish kinetics of oxygen evolution reaction(OER).Currently,scientists are struggling to build out an acid-stable electrocatalyst for OER with low overpotential and excellent stability.In this review,the reaction mechanism and characterization parameters of OER are introduced,and then the improvement method of metal nanocatalysts(noble metal catalysts and noble metal-free catalysts)in acidic media is discussed.Particularly,the application of single-atom catalysts in acidic OER is summarized,which is current researching focus.At the same time,we also briefly introduced the cluster phenomenon,which is easy to occur in the preparation of single-atom catalysts.More importantly,we summarized the in situ characterization methods such as in situ X-ray absorption spectroscopy,in situ X-ray photoelectron spectroscopy,and so forth,which are conducive to further understanding of OER reaction intermediates and active sites.Finally,we put forward some opinions on the development of acidic OER. | Nadia Ismail Fengjuan Qin Chaohe Fang Dan Liu Bihan Liu Xiangyu Liu Zi-long Wu Zhuo Chen Wenxing Chen | 2021 | Aggregate2021，2，4： | 0 |
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