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| 1 | Inhibition of hypoxia-inducible factor 1 with acriflavine sensitizes hypoxic tumor cells to photodynamic therapy with zinc phthalocyanine-encapsulating cationic liposomes显示文摘光力学的治疗(太平洋夏季时间) 是 tumorlocalized photosensitizer 与光是激动的一种肿瘤治疗在形式,它导致反应的氧种类,肿瘤 vasculature 的破坏,肿瘤组织缺氧,肿瘤房间死亡,和反肿瘤免疫者回答的正式就职的本地生产。然而,先存在肿瘤组织缺氧可以减少肿瘤到由激活组织缺氧可诱导的因素的太平洋夏季时间 1 (HIF-1 ) 幸存小径。因此,我们与吖啶黄(ACF ) 假设了 HIF-1 的那抑制将在人的表皮状的癌(A431 ) 加重房间死亡房间。A431 肿瘤房间的太平洋夏季时间用包含 photosensitizer 锌酞毒(ZnPC ) 的最新发达并且优化的 PEGylated cationic liposomes 被执行。分子的停靠表明 ACF 绑在 HIF-1 的 dimerization 领域,并且共焦的显微镜学在组织缺氧下面从 cytosol 证实了 ACF 的 translocation 到原子核。HIF-1 在 hypoxic,然而并非 normoxic 被稳定, A431 房间列在后面太平洋夏季时间。有 ACF 的 HIF-1 的抑制在 hypoxic 条件下面增加了导致太平洋夏季时间的房间死亡的程度并且减少了 HIF-1 目标基因 VEGF, PTGS2,和 EDN1 的表示。而且,在包含 ZnPC liposomes 的水的核心的 ACF 的合作封装在比得上非包含的 ACF 的太平洋夏季时间功效上产出辅助效果。在结论, HIF-1 与 liposomal ZnPC 贡献 A431 肿瘤房间幸存追随者太平洋夏季时间。HIF-1 与的抑制免费或 liposomal ACF 改进太平洋夏季时间功效。 | Mans Broekgaarden Ruud Weijer Massis Krekorian Bas van den IJssel Milan Kos Lindy K. Alles Albert C. van Wijk1 Zsolt Bikadi Eszter Hazai Thomas M. van Gulik Michal Heger | 2016 | Nano Research2016，9，6： | 4 |
| 2 | Structure and Func- tion of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) 显示文摘 | Ni ZL Bikadi Z Rosenberg MF | 2010 | Curr Drug Metab2010，11，7： | 1 |
| 3 | Induced circular dichroism spectra reveal binding of the antiinflammatory curcumin to human alpha1 acid glycoprotein显示文摘 | ZSILA F BIKADI Z SIMONYI M | 2004 | Bioorg Med Chem2004，12，12： | 1 |
| 4 | Structure and function of the human breast cancer resistance protein (BCRP/ABCG2) 显示文摘 | Ni Z Bikadi Z Rosenberg M F | 2010 | Curr Drug Metab2010，11，7： | 1 |
| 5 | Structure and {unction of the human breast cancer resistance protein(BCRP/ABCG2)显示文摘 | Ni Z Bikadi Z Rosenberg MF | 2010 | Curr Drug Metab2010，11，7： | 1 |
| 6 | Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): identification of polar residues important for drug transport 显示文摘 | Ni Z Bikadi Z Cai X | 2010 | Am J Physiol Cell Physiol2010，299，： | 1 |
| 7 | Predicting P-glycoprotein-mediated drug transport based on support vector machine and three-dimensional crystal structure of P-glycoprotein 显示文摘 | Bikadi Z Hazai I Malik D | 2011 | PLOS ONE2011，6，25： | 1 |
| 8 | 显示文摘 | Tong D Hetenyi C Bikadi Z | 2001 | Chromatographia2001，54，： | 1 |
| 9 | Circular dichroism spectro- scopic studies reveal pH dependent binding of curcumin in the minor groove of natural and synthetic nucleic acids 显示文摘 | Zsila F Bikadi Z Simonyi M | 2004 | Org Biomol Chem2004，2，20： | 1 |
| 10 | Structure and function of the human breast cancer resistance protein ( BCRP/ABCG2 ) 显示文摘 | Ni Z Bikadi Z Rosenberg MF | 2010 | Curr Drug Metab2010，11，7： | 1 |
| 11 | Probing the binding of the flavonoid,quercetin to human serum albumin by circular dichroism,electronic ab-sorption spectroscopy and molecular modelling methods显示文摘 | ZSILA F BIKADI Z SIMONYI M | 2003 | BiochemPharmacol2003，65，： | 1 |
| 12 | Structure and function of the human breast cancer resistance protein(BCRP/ABCG2) 显示文摘 | Ni Z Bikadi Z Rosenberg M F | 2010 | Curr Drug Metab2010，11，7： | 1 |
| 13 | Structure and function of the human breast cancer resistance protein (BCRP/ABCG2)显示文摘 | Ni Z Bikadi Z Rosenberg MF | | 0，，07： | 1 |
| 14 | Probing the binding of the flavonoid, quercetin to human serum albumin by circular dichroism, electronic absorption spectroscopy and molecular modelling methods显示文摘 | Zsila F Bikadi Z Simonyi M | 2003 | Biochem Pharmacol2003，65，： | 1 |
| 15 | 显示文摘 | TONG D HETENYI C BIKADI Z | 2001 | Chromatographia2001，54，： | 1 |
| 16 | Molecular basis of the cotton effects induced by the binding of curcumin to human serum albimin显示文摘 | Zsila F Bikadi Z Simonyi M | 2003 | Tetrahedron:Asymmetry2003，14，16： | 1 |
| 17 | Structure and function ofthe human breast cancer resistance protein(BCRP/ABCG2)显示文摘 | Ni Z Bikadi Z Rosenberg MF | 2010 | Curr Drug Metab2010，11，7： | 1 |
| 18 | Circular dichroism spectroscopic studies reveal pH dependent binding of curcumin in the minor groove of naturul and synthetic nucleic acids 显示文摘 | Zsila F Bikadi Z Simonyi M | 2004 | Org Biomol Chem ( S1477 -0520 )2004，2，： | 1 |
| 19 | Structure and function of the human breast cancer resistance protein(BORP/ABOG2)显示文摘 | Ni Z Bikadi Z Rosenberg MF Mao Q | 2010 | Ourr Drug Metab2010，11，7： | 1 |
| 20 | Structure and function of the human breast cancer resistance protein(BCRP/ABCG2)显示文摘 | Ni Z Bikadi Z Rosenberg MF | 2010 | Curr Drug Metab2010，11，7： | 1 |
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