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| 1 | Pentoxifylline versus prednisolone for severe alcoholic hepatitis:A randomized controlled trial显示文摘AIM:To compare the efficacy of pentoxifylline and prednisolone in the treatment of severe alcoholic hepatitis,and to evaluate the role of different liver function scores in predicting prognosis.METHODS:Sixty-eight patients with severe alcoholic hepatitis(Maddrey score≥32)received pentoxifylline(n=34,groupⅠ)or prednisolone(n=34,groupⅡ) for 28 d in a randomized double-blind controlled study,and subsequently in an open study(with a tapering dose of prednisolone)for a total of 3 mo,and were followed up over a period of 12 mo.RESULTS:Twelve patients in groupⅡdied at the end of 3 mo in contrast to five patients in groupⅠ.The probability of dying at the end of 3 mo was higher in groupⅡas compared to groupⅠ(35.29%vs 14.71%,P=0.04;log rank test).Six patients in groupⅡ developed hepatorenal syndrome as compared to none in groupⅠ.Pentoxifylline was associated with a significantly lower model for end-stage liver disease(MELD)score at the end of 28 d of therapy(15.53±3.63 vs 17.78±4.56,P=0.04).Higher baseline Maddrey score was associated with increased mortality.CONCLUSION:Reduced mortality,improved risk-benefit profile and renoprotective effects of pentoxifylline compared with prednisolone suggest that pentoxifylline is superior to prednisolone for treatment of severe alcoholic hepatitis. | Binay Krishna De Subhabrata Gangopadhyay Deep Dutta Sumanta Das Baksi Adyapad Pani Pramit Ghosh | 2009 | World Journal of Gastroenterology2009，15，13： | 26 |
| 2 | 精浆抗精子抗体对精子形态及运动特征的影响显示文摘目的:探讨精浆抗精子抗体(AsAb)对精子形态和运动特征的影响。方法:检测251例男性不育患者精液样本,采用酶联免疫法进行AsAb检测,计算机自动分析精子运动特征,采用精子形态检测系统下人工修正方法进行精子形态分析。结果:251例男性不育患者中,AsAb阳性率为17·13%。AsAb阳性组正常形态精子百分率与阴性组无显著性差异(P>0·05),大头精子和锥形头精子百分率显著高于AsAb阴性组(P<0·05,P<0·005)。精浆AsAb阳性组a+b级精子百分率,精子运动参数MAD、LIN、WOB均明显低于阴性组,两组比较差异有显著性(P<0·05,P<0·01)。结论:精浆AsAb不影响正常形态精子百分率,但能使锥形头精子百分率显著升高;使a+b级精子百分率、精子运动参数MAD、LIN、WOB明显降低。 | 任明 田芹 许宗革 张明 Binay Kumar Adhikari 刘睿智 | 2008 | 中国妇幼保健2008，23，17： | 14 |
| 3 | 不育男性精浆锌与精子密度、形态及运动性关系探讨显示文摘目的探讨不育男性精浆锌与精子密度、形态及运动性的关系。方法分析87例男性不育患者精液样本,采用计算机辅助精液分析进行精液参数检测,采用精子形态检测系统下人工修正方法进行精子形态分析,采用分光光度比色法测定精浆锌含量。结果不育男性精浆锌含量与精子密度之间有显著的正相关性(r=0.355,P<0.05),与MAD和BCF之间有显著的正相关性(r分别为0.232和0.266,P<0.05),而与精子活力、精子形态之间差异没有显著性关系(P>0.05)。密度异常组精浆锌含量显著低于密度正常组和生育组(P<0.01)。活力异常组精浆锌含量与活力正常组和生育组比较差异均无显著性(P>0.05)。形态异常组精浆锌含量与形态正常组、生育组比较差异均无显著性(P>0.05)。结论精浆锌含量降低能使精子密度下降,但对精子活力和形态没有显著影响。 | 李付彪 郭淑英 许宗革 刘祥印 Binay 刘睿智 | 2008 | 中国现代医学杂志2008，18，11： | 5 |
| 4 | CD8^+效应性T细胞促高血压心肌纤维化的炎性反应显示文摘低度炎症反应在心血管疾病中的作用已被证明,特别是对高血压,低度炎症反应是导致高血压病人心肌纤维化的因素之一,主要表现为间质中胶原沉积增多,各型胶原比率失调和排列紊乱。心肌纤维化过程中,可激活相应的免疫机制,使T淋巴细胞及巨噬细胞等细胞活化,产生和释放多种活性因子,激活心肌的细胞外基质生成, | 吴金风 Binay Kumar Adhikari 孟晓萍 | 2012 | 中国实验诊断学2012，16，2： | 4 |
| 5 | 胸壁肿瘤切除后的一期修复重建显示文摘目的 观察胸壁肿瘤切除术后胸壁缺损一期修复重建的临床效果。 方法 1998年1月~2 0 0 3年3月外科治疗胸壁肿瘤31例。男2 0例,女11例。年龄8~72岁。原发性胸壁肿瘤2 1例,肺癌侵犯胸壁6例,乳腺癌术后复发2例,放射性坏死和皮肤癌各1例。切除肋骨2~7根,平均3.6根。缺损面积2 0~2 2 0 cm2 ,平均97.1cm2 。合并肺切除10例,部分膈肌切除2例,胸骨下段切除1例。单纯软组织修复7例(背阔肌+大网膜,背阔肌肌皮瓣,背阔肌肌瓣) ,单纯骨性重建5例(涤纶布或Prolene网) ,骨性合并软组织修复19例(背阔肌、胸大肌、背阔肌+阔筋膜或大网膜,与涤纶布或Prolene网修复)。 结果 术后发生并发症3例( 9.7% ) ,其中切口感染1例,软组织与修复物之间积液2例。无手术死亡。2 6例获5~5 7个月随访,术后生存时间6~5 7个月,中位生存时间2 2个月。 结论 胸壁肿瘤切除术后造成的巨大缺损。 | 檀振波 Nirmal Lamichhane 刘登湘 肖奇海 Binay Kumar Thakur | 2005 | 中国修复重建外科杂志2005，19，5： | 4 |
| 6 | Hemodynamic effects of propranolol with spironolactone in patients with variceal bleeds: A randomized controlled trial显示文摘AIM: To study the hemodynamic effects of spironolactone with propranolol vs propranolol alone in the secondary prophylaxis of variceal bleeding. METHODS: Thirty-five cirrhotics with variceal bleeding randomly received propranolol (n = 17: Group A) or spironolactone plus propranolol (n = 18: Group B). Hemodynamic assessment was performed at baseline and on the eighth day. RESULTS: Spironolactone with propranolol caused a greater reduction in the hepatic venous pressure gradient than propranolol alone (26.94% vs 10.2%; P < 0.01). Fourteen out of eighteen patients on the combination treatment had a reduction in hepatic venous pressure gradient to ≤ 12 mmHg or a 20% reduction from baseline in contrast to only six out of seventeen (6/17) on propranolol alone (P < 0.05). CONCLUSION: Spironolactone with propranolol results in a better response with a greater reduction in hepatic venous pressure gradient in the secondary prophylaxis of variceal bleeding. A greater number of patients may be protected by this combination therapy than by propranolol alone. Hence, this combination may be recommended for secondary prophylaxis in patients with variceal bleeding. | Binay K De Deep Dutta Rimi Som Pranab K Biswas Subrata K Pal Anirban Biswas | 2008 | World Journal of Gastroenterology2008，14，12： | 3 |
| 7 | Targeted therapy for leptomeningeal metastases in non-small cell lung cancer-Changing treatment paradigms显示文摘Leptomeningeal metastasis is an uncommon but serious complication in patients with advanced cancers.Leptomeningeal metastasis is diagnosed in approximately 5% of the patients,most commonly among patients with cancers of breast and lung,melanoma,and gastrointestinal malignancies.Treatment goal is to improve survival and quality of the patients.Use of targeted therapies and immunotherapy has led to improved survival of patients with non-small cell lung cancer(NSCLC).In this article,we review emerging data on use of mutation-specific agents and immunotherapy in the treatment of leptomeningeal metastasis among patients with NSCLC. | Binay Kumar Shah Isaac Pak Nibash Budhathoki Kayla Buker | 2017 | Chinese Journal of Cancer Research2017，29，6： | 3 |
| 8 | 化湿通瘀补气法对延缓家兔动脉粥样硬化斑块形成的实验研究显示文摘目的观察化湿通瘀补气法延缓高脂饮食兔动脉粥样硬化(AS)斑块形成的作用。方法纯种新西兰雄性大白兔(4个月月龄)18只作为实验对象,常规喂养1周后随机分为3组,每组6只。改为高脂饮食(1%胆固醇+6%蛋黄粉+8%猪油+85%基础饲料)喂养,对照组不用药,中药干预组用荷叶、泽泻、虎杖等中药,西药干预组用阿司匹林+阿托伐他汀+普罗布考。各组3个月后分别抽取耳缘静脉血,测定总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、基质金属蛋白酶9(MMP-9)、丙二醛(MDA)、氧化低密度脂蛋白(ox-LDL)值,然后处死动物,取主动脉组织作苏木精-伊红染色切片及免疫组化染色,观察主动脉病理组织学变化,测定各组主动脉内膜及内膜/中膜厚度。结果中药干预组和西药干预组的TC、TG和LDL-C均比对照组明显降低(P<0.01),TC(2.39±0.15)mmol/L,(2.08±0.12)mmol/L vs(13.02±0.20)mmol/L;TG(2.58±0.16)mmol/L,(1.90±0.08)mmol/L vs(11.08±0.19)mmol/L;西药干预组还低于中药干预组(P<0.01),LDL-C(1.05±0.24)mmol/L,(0.85±0.09)mmol/L vs(10.13±0.20)mmol/L(P<0.01);MDA、ox-LDL、MMP-9水平较对照组均有不同程度降低(P<0.01)。中药干预组和西药干预组主动脉内膜厚度较对照组明显降低,分别为(12.28±1.28)μm、(5.20±0.81)μm vs(40.06±3.94)μm(P<0.01),而西药干预组比中药干预组降低明显。结论化湿通瘀补气法能延缓兔动脉内斑块形成,降低LDLC,为中医药治疗及动脉粥样硬化提供新的研究理论依据。 | 徐瑞平 于海翔 Binay Kumar Adhikari 孟晓萍 | 2013 | 临床荟萃2013，28，10： | 3 |
| 9 | Studies of grand minima in sunspot cycles by using a flux transport solar dynamo model显示文摘We propose that grand minima in solar activity are caused by simultaneous fluctuations in the meridional circulation and the Babcock–Leighton mechanism for the poloidal field generation in the flux transport dynamo model.We present the following results:(a)fluctuations in the meridional circulation are more effective in producing grand minima;(b)both sudden and gradual initiations of grand minima are possible;(c)distributions of durations and waiting times between grand minima seem to be exponential;(d)the coherence time of the meridional circulation has an effect on the number and the average duration of grand minima,with a coherence time of about 30 yr being consistent with observational data.We also study the occurrence of grand maxima and find that the distributions of durations and waiting times between grand maxima are also exponential,like the grand minima.Finally we address the question of whether the Babcock–Leighton mechanism can be operative during grand minima when there are no sunspots.We show that anα-effect restricted to the upper portions of the convection zone can pull the dynamo out of the grand minima and can match various observational requirements if the amplitude of thisα-effect is suitably fine-tuned. | Bidya Binay Karak Arnab Rai Choudhuri | 2013 | Research in Astronomy and Astrophysics2013，13，11： | 2 |
| 10 | 触摸屏技术推动消费电子产品增长显示文摘智能手机和平板电脑在现今社会中无所不在,企业的使用与消费者同样多,今年市场上推出了许多竞争的平板电脑产品。触摸屏应用数年前率先在较小的设备上推出,基于触摸屏应用的市场正在快速演变进入较大尺寸设备。对于计算和电子设备制造商,这个新的市场不仅是最新的消费者狂热,它可能代表着人们与提供信息和计算之硬件的交互方式的基本改变。 | Binay Bajaj | 2013 | 中国电子商情2013，，6： | 2 |
| 11 | 食管-胃颈部吻合中改良单层Gambee氏吻合法的应用显示文摘食管癌是我国高发病之一,目前手术依然是首选的治疗方式。由于颈部是个极特殊的部位,传统的手工吻合及吻合器的使用很不方便,受到一定的限制。多年来,临床医师在吻合方式上已进行了多项改良和探索,各方法都有优缺点。 | 张春山 孟惠彦 Binay thakur | 2010 | 中国肿瘤外科杂志2010，2，1： | 2 |
| 12 | Therm odynam ic and kinetic investigations of uranium adsorption on amber-lite IR-118H resin显示文摘 | Ayben K Binay B | 2003 | Applied radiation and isotopes2003，58，5： | 1 |
| 13 | Interleukin - 18 : biological properties and clinical implication 显示文摘 | Lebel - Binay S Berger A Zinzindohoue F | 2000 | Eur Cytokine Netw2000，11，1： | 1 |
| 14 | Thermodynamic and kinetic investi-gations of uranium adsorption on amberlite IR - 118Hresin显示文摘 | Ayben K Binay B | 2003 | Applied Radiation and Isotopes2003，58，2： | 1 |
| 15 | Thermodynamic and kinetic investigations of uranium adsorption on amberlite IR-118H resin显示文摘 | Ayben Kilislioglu Binay Bilgin | 2003 | Applied Radiation and Isotopes2003，，2： | 1 |
| 16 | Thermodynamic and kinetic investigations of uranium adsorption on amberlite IR- 118H resin显示文摘 | Ayben Kilislioglu Binay Bilgin | 2003 | Applied Radiation and Isotopes2003，58，2： | 1 |
| 17 | Thermodynamic and kinetic investigations of uranium adsorption on amberlite IR-118H resin显示文摘 | Ayben K Binay B | | 0，，02： | 1 |
| 18 | Expression of estro- gen receptor alpha increases leptin-induced STAT3 activ- ity in breast cancer cells 显示文摘 | Binai NA Damert A Carra G | 2010 | Cancer2010，127，1： | 1 |
| 19 | Thermodynamic and kinetic investigations of uranium adsorption on amberlite IR-118H resin显示文摘 | AYBEN K BINAY B | 2003 | Appl Radiat Isot2003，58，： | 1 |
| 20 | On the adsorption and diffusion of Methylene Blue in glass fibers显示文摘 | Sampa Chakrabarti Binay K. Dutta | 2005 | Journal of Colloid And Interface Science2005，，2： | 1 |
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