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| 1 | Overexpression of ornithine-δ-aminotransferase increases proline biosynthesis and confers osmotolerance in transgenic plants显示文摘 | Nancy H. Roosens Fawaz Al Bitar Kristof Loenders Geert Angenon Michel Jacobs | 2002 | Molecular Breeding2002，，2： | 1 |
| 2 | Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase3β显示文摘 | AlMulla F Bitar M S AlMaghrebi M | 2011 | Cancer Res2011，71，4： | 1 |
| 3 | Clinical implications for loss or diminution of expression of Raf1 kinase inhibitory protein and its phosphorylated form in ductal breast cancer显示文摘 | AlMulla F Bitar M S Thiery J P | 2013 | Am J Cancer Res2013，3，5： | 1 |
| 4 | Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and threedimensional in vitro models显示文摘BACKGROUND Colorectal cancer(CRC) is the second leading cause of cancer-related mortality.Cancer stem cells(CSCs) in CRC, which are spared by many chemotherapeutics,have tumorigenic capacity and are believed to be the reason behind cancer relapse. So far, there have been no effective drugs to target colon CSCs. Diiminoquinone(DIQ) has shown promising effects on targeting colon cancer.However, there is limited research on the effects of DIQ on eradicating CSCs in CRC.AIM To investigate the anticancer potential of DIQ on colon CSCs in two-dimensional(2D) and three-dimensional(3D) models using colonospheres and patient-derived organoids.METHODS Various 2D methods have been used to assess the effect and the mechanism of DIQ on HCT116and HT29 cell lines including cell proliferation and viability assays, migration and invasion assays,immunofluorescence staining, and flow cytometry. The potency of DIQ was also assessed in 3D culture using the sphere formation assay and colon cancer patient-derived organoid model.RESULTS Our results showed that DIQ significantly inhibited cell proliferation, migration, and invasion in HCT116 and HT29 cell lines. DIQ treatment induced apoptosis along with an accumulation of HCT116 and HT29 cancer cells in the sub-G1 region and an increase in reactive oxygen species in both CRC cell lines. DIQ reduced sphere-forming and self-renewal ability of colon cancer HCT116and HT29 stem/progenitor cells at sub-toxic doses of 1 μmol/L. Mechanistically, DIQ targets CSCs by downregulating the main components of stem cell-related-catenin, AKT, and ERK oncogenic signaling pathways. Potently, DIQ displayed a highly significant decrease in both the count and the size of the organoids derived from colon cancer patients as compared to control and 5-fluorouracil conditions.CONCLUSION This study is the first documentation of the molecular mechanism of the novel anticancer therapeutic DIQ via targeting CSC, a promising compound that needs further investigation. | Alissar Monzer Kevork Wakimian Farah Ballout Samar Al Bitar Amani Yehya Mariam Kanso Nour Saheb Ayman Tawil Samer Doughan Maher Hussein Deborah Mukherji Walid Faraj Hala Gali-Muhtasib Wassim Abou-Kheir | 2022 | World Journal of Gastroenterology2022，28，33： | 1 |
| 5 | High incidence of renal artery stenosis in patients with coronry artery disease 显示文摘 | Jean WJ Al - Bitar I Zwieke DL | 1994 | Catheter Cardivasc Diag1994，32，： | 1 |
| 6 | Resistance to as- pirin and clopidogrel therapy显示文摘 | Musallam KM Charafeddine K Bitar A ef al | 2011 | lnt J Lab Hematol2011，33，1： | 1 |
| 7 | Disaggregation ofSMOS soil moisture in southeastern Australia 显示文摘 | Merlin O Rudiger C Al Bitar A | 2012 | IEEETransactions on Geoscience and Remote Sensing2012，50，5： | 1 |
| 8 | Evaluation of SMOSsoil moisture products over continental US using the SCAN/SNOTEL network显示文摘 | Al Bitar A Leroux D Kerr Y H | 2012 | IEEE Transactions on Geoscience andRemote Sensing2012，50，5： | 1 |
| 9 | Overexpression of ornithine-δ-aminotransferase increases proline biosynthesis and confers osmotolerance in transgenic plants显示文摘 | ROOSENS N H AL BITAR F LOENDERS K | 2002 | Molecular Breeding:New Strategies in Plant Improvement2002，9，2： | 1 |
| 10 | Viabahn for femoropopli- teal in-stent restenosis显示文摘 | Al Shammeri O Bitar F Ghitelman J | 2012 | Ann Saudi Med2012，32，6： | 1 |
| 11 | Studying the Performances of Induction Motor Used in Electric Car显示文摘 | Zeina Bitar Samih Al Jabi | 2014 | Energy Procedia2014，，： | 1 |
| 12 | Modeling and Simulation of Series DC Motors in Electric Car显示文摘 | Zeina Bitar Samih Al Jabi Imad Khamis | 2014 | Energy Procedia2014，，： | 1 |
| 13 | Apoptosis and theactivity of ceramide,Bax and Bcl-2 in the lungs of neonamlrats exposed to limited and prolonged hyperoxia显示文摘 | Husari AW Dbaibo GS Bitar al | 2006 | RespirRts2006，7，： | 1 |
| 14 | The role of theophylline in prevention of radiocontrast media - induced nephropathy 显示文摘 | Malhis M Al - Bitar S AI - Deen Zaiat K | 2010 | Saudi J Kidney Dis Transpl2010，21，2： | 1 |
| 15 | Genetic profiling of statge Ⅰ and Ⅱ colorectal cancer may predict metastatic relapse显示文摘 | A1-Mulla F Behbehani AL bitar MS | 2006 | Mod Pathol2006，19，5： | 1 |
| 16 | Evalua- tion of SMOS soil moisture products over continental US using the SCAN/SNOTEL network 显示文摘 | AL BITAR A LEROUX D KERR Y H | 2012 | IEEE Transactions on Geoscience and Remote Sensing2012，50，5： | 1 |
| 17 | Viabahn for femoropopliteal in-stent restenosis显示文摘 | Al Shammeri O Bitar F Ghitelman J | 2012 | Ann Saudi Med2012，32，6： | 1 |
| 18 | Molecular mechanisms targeting drug-resistance and metastasis in colorectal cancer:Updates and beyond显示文摘Colorectal cancer(CRC)is the third most diagnosed malignancy and a major leading cause of cancer-related deaths worldwide.Despite advances in therapeutic regimens,the number of patients presenting with metastatic CRC(mCRC)is increasing due to resistance to therapy,conferred by a small population of cancer cells,known as cancer stem cells.Targeted therapies have been highly successful in prolonging the overall survival of patients with mCRC.Agents are being developed to target key molecules involved in drug-resistance and metastasis of CRC,and these include vascular endothelial growth factor,epidermal growth factor receptor,human epidermal growth factor receptor-2,mitogen-activated extracellular signal-regulated kinase,in addition to immune checkpoints.Currently,there are several ongoing clinical trials of newly developed targeted agents,which have shown considerable clinical efficacy and have improved the prognosis of patients who do not benefit from conventional chemotherapy.In this review,we highlight recent developments in the use of existing and novel targeted agents against drug-resistant CRC and mCRC.Furthermore,we discuss limitations and challenges associated with targeted therapy and strategies to combat intrinsic and acquired resistance to these therapies,in addition to the importance of implementing better preclinical models and the application of personalized therapy based on predictive biomarkers for treatment selection. | Samar Al Bitar Marwan El-Sabban Samer Doughan Wassim Abou-Kheir | 2023 | World Journal of Gastroenterology2023，29，9： | 1 |
| 19 | Sequence analysis,tran- scriptional and posttranseriptional regulation of the rice vdac family 显示文摘 | AL BITAR F ROOSENS N SMEYERS M | 2003 | Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression2003，1625，1： | 1 |
| 20 | Apoptosis and theactivity of ceramide,Bax and Bcl-2 in the lungs of neonamlrats exposed to limited and prolonged hyperoxia显示文摘 | Husari AW Dbaibo GS Bitar al | 2006 | RespirRts2006，7，： | 1 |
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