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| 1 | IL-17 induces radiation resistance of B lymphoma cells by suppressing p53 expression and thereby inhibiting irradiation-triggered apoptosis显示文摘p53 是著名肿瘤 suppressor。然而,为在 B 淋巴瘤房间的 p53 表示的规章的机制,和在在肿瘤房间的辐射抵抗的开发的 p53 的可能的角色大部分是未知的。一根人的 B 淋巴瘤房间线, Karpas1106 (k1106 ) ,被用作辐射抵抗的一个模型。k1106 房间的 Apoptosis 用流动 cytometry 被决定。p53 的表示用实时 RT-PCR 并且西方的弄污被估计。结果证明在 8Gy 的那照耀在多达 40 % 导致了 apoptosis;k1106 房间。同时,照耀显著地增加了 k1106 房间的 IL-6 生产。当 k1106 房间是有规章的 T 房间(Tregs ) 的 cocultured 并且照耀时, apoptotic k1106 房间的率显著地被减少,显示到照耀的一个获得的电阻。从对待照耀的 k1106 房间导出的 IL-6 在 Tregs 导致了 IL-17 表示。IL-17 + Foxp3 + T 房间在 k1106 房间压制了 p53 表示。一起,照耀 k1106 房间在 Tregs 导致 IL-17 的表示,它在 k1106 房间防碍 p53 蛋白质的表示并且从而镇压在 k1106 房间的被触发照耀的 apoptosis。 | Qingshan Li Xin Xu Weijie Zhong Qinghua Du Bizhen Yu Huabao Xiong | 2015 | Cellular & Molecular Immunology2015，12，3： | 8 |
| 2 | Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis:a prospective multicenter randomized controlled trial显示文摘Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate anticoagulation(RCA)combined with sequential anticoagulation and standard calcium-containing dialysate in intermittent hemodialysis(IHD)treatment.Methods:Patients at high risk of bleeding who underwent IHD from September 2019 to May 2021 were prospectively enrolled in 13 blood purification centers of nephrology departments,and were randomly divided into RCA group and saline flushing group.In the RCA group,0.04 g/mL sodium citrate was infused from the start of the dialysis line during blood draining and at the venous expansion chamber.The sodium citrate was stopped after 3 h of dialysis,which was changed to sequential dialysis without anticoagulant.The hazard ratios for coagulation were according to baseline.Results:A total of 159 patients and 208 sessions were enrolled,including RCA group(80 patients,110 sessions)and saline flushing group(79 patients,98 sessions).The incidence of severe coagulation events of extracorporeal circulation in the RCA group was significantly lower than that in the saline flushing group(3.64%vs.20.41%,P<0.001).The survival time of the filter pipeline in the RCA group was significantly longer than that in the saline flushing group((238.34±9.33)min vs.(221.73±34.10)min,P<0.001).The urea clearance index(Kt/V)in the RCA group was similar to that in the saline flushing group with no statistically significant difference(1.12±0.34 vs.1.08±0.34,P=0.41).Conclusions:Compared with saline flushing,the two-stage RCA combined with a sequential anticoagulation strategy significantly reduced extracorporeal circulation clotting events and prolonged the dialysis time without serious adverse events. | Xiaoyan TANG Dezheng CHEN Ling ZHANG Ping FU Yanxia CHEN Zhou XIAO Xiangcheng XIAO Weisheng PENG Li CHENG Yanmin ZHANG Hongbo LI Kehui LI Bizhen GOU Xin WU Qian YU Lijun JIAN Zaizhi ZHU Yu WEN Cheng LIU Hen XUE Hongyu ZHANG Xin HE Bin YAN Liping ZHONG Bin HUANG Mingying MAO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，11： | 4 |
| 3 | COVID-19 epidemic prediction and the impact of public health interventions: A review of COVID-19 epidemic models显示文摘The coronavirus disease outbreak of 2019(COVID-19)has been spreading rapidly to all corners of the word,in a very complex manner.A key research focus is in predicting the development trend of COVID-19 scientifically through mathematical modelling.We conducted a systematic review of epidemic prediction models of COVID-19 and the public health intervention strategies by searching the Web of Science database.55 studies of the COVID-19 epidemic model were reviewed systematically.It was found that the COVID-19 epidemic models were different in the model type,acquisition method,hypothesis and distribution of key input parameters.Most studies used the gamma distribution to describe the key time period of COVID-19 infection,and some studies used the lognormal distribution,the Erlang distribution,and theWeibull distribution.The setting ranges of the incubation period,serial interval,infectious period and generation time were 4.9-7 days,4.41-8.4 days,2.3-10 days and 4.4-7.5 days,respectively,and more than half of the incubation periods were set to 5.1 or 5.2 days.Most models assumed that the latent period was consistent with the incubation period.Some models assumed that asymptomatic infections were infectious or pre-symptomatic transmission was possible,which overestimated the value of R0.For the prediction differences under different public health strategies,the most significant effect was in travel restrictions.There were different studies on the impact of contact tracking and social isolation,but it was considered that improving the quarantine rate and reporting rate,and the use of protective face mask were essential for epidemic prevention and control.The input epidemiological parameters of the prediction models had significant differences in the prediction of the severity of the epidemic spread.Therefore,prevention and control institutions should be cautious when formulating public health strategies by based on the prediction results of mathematical models. | Yue Xiang Yonghong Jia Linlin Chen Lei Guo Bizhen Shu Enshen Long | 2021 | Infectious Disease Modelling2021，6，1： | 3 |
| 4 | Nitric oxide, g-aminobutyric acid, and mannose pretreatment influence metabolic profiles in white clover under water stress显示文摘Nitric oxide(NO),γ-aminobutyric acid(GABA),and mannose(MAS)could be important regulators of plant growth and adaptation to water stress.The application of sodium nitroprusside(SNP,a NO donor),GABA,and MAS improved plant growth under watersufficient conditions and effectively mitigated water stress damage to white clover.The metabonomic analysis showed that both SNP and GABA application resulted in a significant increase in myo-inositol content;the accumulation of mannose was commonly regulated by SNP and MAS;GABA and MAS induced the accumulation of aspartic acid,quinic acid,trehalose,and glycerol under water deficit.In addition,citric acid was uniquely up-regulated by SNP associated with tricarboxylic acid(TCA)cycle under water stress.GABAspecially induced the accumulation of GABA,glycine,methionine,and aconitic acid related to GABA shunt,amino acids metabolism,and TCA cycle in response to water stress.MAS uniquely enhanced the accumulation of asparagine,galactose,and D-pinitol in association with amino acids and sugars metabolism under water stress.SNP-,GABA-,and MAS-induced changes of metabolic profiles and associated metabolic pathways could contribute to enhanced stress tolerance via involvement in the TCA cycle for energy supply,osmotic adjustment,antioxidant defense,and signal transduction for stress defense in white clover. | Zhou Li Bin Yong Bizhen Cheng Xing Wu Yan Zhang Xinquan Zhang Yan Peng | 2019 | Journal of Integrative Plant Biology2019，61，12： | 2 |
| 5 | Phase retrieval from two intensity measurements in an optical system involving nonunitary transformation显示文摘 | Li Wang Bizhen Dong Guozhen Yang | 1990 | Applied Optics1990，29，： | 1 |
| 6 | Gerchberg-Saxton and Yang-Gu algorithms for phase retrieval in a nonunitary transform system:a comparison显示文摘 | Guozhen Yang Bizhen Dong Benyuan Gu | 1994 | Applied Optics1994，33，： | 1 |
| 7 | Functional bowel disorders in apparently health Chinese people显示文摘 | Bizhen W Qiying P | 1998 | Clin Epidemiol1998，9，4： | 1 |
| 8 | A method for modeling and simulation of differential drive mobile robot localization based on EKF muhisensor fusion显示文摘 | Bao Bizhen Yang Ping Cao Huwcn | 2011 | Advanced Materials Research2011，，： | 1 |
| 9 | A Highly Active Heterogeneous Palladium Catalyst for the Suzuki-Miyaura and Ullmann Coupling Reactions of Aryl Chlorides in Aqueous Media显示文摘 | Yuan Bizhen Pan Yingyi Li Yingwei | | 0，，24： | 1 |
| 10 | On the amplitude phase retrieval problem in an optical system involved non unitary trans formation显示文摘 | Yang Guozhen Gu Benyuan Dong Bizhen | 1987 | Optik1987，75，2： | 1 |
| 11 | Gerchberg- Saxton and Yang-Gu algorithms or phase retrieval in a nonunitary transform system: a comparison 显示文摘 | Yang Guozhen Dong Bizhen Gu Benyuan | 1994 | Applied Optics1994，33，2： | 1 |
| 12 | Generation of polarized patterns with the use of polarization selective diffractive phase elements显示文摘 | Liu Juan Dong Bizhen Gu Benyuan | 1999 | Optik1999，110，7： | 1 |
| 13 | Polarization-selective diffractive phase element for implementing polarization mode selecting, color demultiplexing, and spatial focusing simultaneously显示文摘 | Liu Juan Dong Bizhen Gu Benyuan | 2000 | Optik2000，111，2： | 1 |
| 14 | Expriments of diffractive phase elements capble of realizing desired functions in rotationally symmetric optical system显示文摘 | Liu Rong Dong Bizhen Zhang Yan | 1999 | Optik1999，110，3： | 1 |
| 15 | Allelopathic effects of Eucalyptus urophylla on ten tree species in south China显示文摘 | FANG Bizhen YU Shixiao WANG Yongfan | 2009 | Agroforestry Systems2009，76，： | 1 |
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