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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | Time course of cytokine,corticosterone,and tissue injury responses in mice during heat strain recovery显示文摘 | LEON L R BLAHA M D DUBOSE D A | 2006 | J Appl Physiol2006，100，4： | 1 |
| 3 | Molecular signature of mice T lymphocytes following tolerance induction by allogeneic BMT and CD40-CD40L costimulation blockade显示文摘 | Perco P Blaha P Kainz A | | 0，，02： | 1 |
| 4 | Changes of central haemodynamic parameters during mental stress and acute bouts of static and dynamic exercise显示文摘 | LYDAKIS C MOMEN A BLAHA C et a l | 2008 | J Hum Hypertens2008，22，5： | 1 |
| 5 | Changes of elastic properties of central arteries during acute static exercise and lower body negative pressure显示文摘 | LYDAKIS C MOMEN A BLAHA C | 2008 | Eur J Appl Physiol2008，102，6： | 1 |
| 6 | Sexual behavior enhances central dopamine transmission in the males pacerat 显示文摘 | Pfaus J G Damsma G Nomikos G G Wenkstern D G Blaha C D Phillips A G Fibiger H C | 1990 | Brain Res1990，530，2： | 1 |
| 7 | Formation of the first peptide bond: the structure of EF-P bound to the 70 S ribosome 显示文摘 | Blaha G Stanley R E Steitz T A | 2009 | Science2009，325，： | 1 |
| 8 | Non-ammonia deliming of cattle hides with magnesium lactate显示文摘 | Blaha A Bailey D G | 1996 | J Am Leather Chem Assoc1996，91，2： | 1 |
| 9 | Effect of atorvastatin on soluble CD14, CD40 Ligand, sE- and sP-selectins and MCP- 1 in patients with type 2 diabetes mellitus: relationship to cholesterol turnover显示文摘 | Blaha V Andrys C Smahelova A | 2006 | Pharmacol Res2006，54，： | 1 |
| 10 | Reduction of waste of tannery industry by recycling of dairy by products显示文摘 | P Sáha A Blaha | 1994 | Journal of Hazardous Materials1994，37，1： | 1 |
| 11 | Molecular signature of mice T Iymphocytes following tolerance induction by allogeneic BMT and CD40-CD40L costimulation blockade显示文摘 | Perco P Blaha P Kainz A | 2006 | Transpl Int2006，19，2： | 1 |
| 12 | Influence of immunosuppressive drugs on cell-induced graft tolerance显示文摘 | Heiger A Blaha P Bigenzahn S | 2004 | Curr Opin Organ Transplant2004，9，3： | 1 |
| 13 | Omega-3 fatty acids for cardiovascular disease prevention显示文摘 | DEFILIOOIS A P BLAHA M J JACOBSON T A | 2010 | Curr Treat Options Cardiovasc Med2010，12，4： | 1 |
| 14 | Gas-liquid Two -phase Flow in Microfiltration Mineral Tubular Membranes: Relationship Between Flux Enhancement and hydrodynamic Parameters 显示文摘 | Cakl J Medvedikova L Blaha A | 1998 | Separation Science and Technology1998，33，9： | 1 |
| 15 | Nonammonia deliming of cattle hides with magnesium lactate 显示文摘 | Kolomaznik K Blaha A Dedrle T | 1996 | Journal of the American Leather Chemists Association1996，91，1： | 1 |
| 16 | Molecular signature of mice T lymphocytes following tolerance induction by allogeneic BMT and CD40-CD40L costimulation blockade 显示文摘 | Perco P Blaha P Kainz A | 2006 | Transpl Int2006，19，2： | 1 |
| 17 | Kneeling is safe for patients implanted with medial-pivot total knee arthroplasty designs 显示文摘 | Barnes CL Sharma A Blaha JD | 2011 | J Arthroplasty2011，26，4： | 1 |
| 18 | Non-ammonia deliming of cattle hides with magnesium lactate显示文摘 | Kolomaznik K Blaha A Bailey D G | 1996 | J Am Leather Chem Assoe1996，91，2： | 1 |
| 19 | Molecular signature of mice T lymphocytes following tolerance induction by allogeneic BMT and CD40 - CD40L costimulation blockade显示文摘 | Perco P Blaha P Kainz A | 2006 | Transpl Int2006，19，2： | 1 |
| 20 | Reduc- tion of waste of tannery industry by recycling of dairy by products显示文摘 | Kolomaznik P SOha A Blaha | 1994 | Jourhal of Hazardous Materials1994，37，1： | 1 |
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