|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis显示文摘Helicobacter pylori(H.pylori)is an infectious agent influencing as much as 50%of the world’s population.It is the causative agent for several diseases,most especially gastric and duodenal peptic ulcer,gastric adenocarcinoma and mucosaassociated lymphoid tissue lymphoma of the stomach.A number of other,extragastric manifestations also are associated with H.pylori infection.These include neurological disorders,such as Alzheimer’s disease,demyelinating multiple sclerosis and Parkinson’s disease.There is also evidence for a relationship between H.pylori infection and such dermatological diseases as psoriasis and rosacea as well as a connection with infection and open-angle glaucoma.Generally little is known about the relationship between H.pylori infection and diseases of the pancreas.Most evidence about H.pylori and its potential role in the development of pancreatic diseases concerns pancreatic adenocarcinoma and autoimmune forms of chronic pancreatitis.There is data(albeit not fully consistent)indicating modestly increased pancreatic cancer risk in H.pylori-positive patients.The pathogenetic mechanism of this increase is not yet fully elucidated,but several theories have been proposed.Reduction of antral Dcells in H.pylori-positive patients causes a suppression of somatostatin secretion that,in turn,stimulates increased secretin secretion.That stimulates pancreatic growth and thus increases the risk of carcinogenesis.Alternatively,H.pylori,as a part of microbiome dysbiosis and the so-called oncobiome,is proven to be associated with pancreatic adenocarcinoma development via the promotion of cellular proliferation.The role of H.pylori in the inflammation characteristic of autoimmune pancreatitis seems to be explained by a mechanism of molecular mimicry among several proteins(mostly enzymes)of H.pylori and pancreatic tissue.Patients with autoimmune pancreatitis often show positivity for antibodies against H.pylori proteins.H.pylori,as a part of microbiome dysbiosis,also is viewed as a potential trigger of autoimmune inflammation of the pancreas.It is precisely these relationships(and associated equivocal conclusions)that constitute a center of attention among pancreatologists,immunologists and pathologists.In order to obtain clear and valid results,more studies on sufficiently large cohorts of patients are needed.The topic is itself sufficiently significant to draw the interest of clinicians and inspire further systematic research.Next-generation sequencing could play an important role in investigating the microbiome as a potential diagnostic and prognostic biomarker for pancreatic cancer. | Lumir Kunovsky Petr Dite Petr Jabandziev Jiri Dolina Jitka Vaculova Martin Blaho Martina Bojkova Jana Dvorackova Magdalena Uvirova Zdenek Kala Jan Trna | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 5 |
| 2 | Dexterity measures for the design and control of kinematically redundant manipulators显示文摘 | Klein C A Blaho B E | 1987 | Inter J of Robotics Research1987，6，2： | 1 |
| 3 | Blood cocaine and metabolite concentrations,clinical findings, and outcome of patients presenting to an ED 显示文摘 | Blaho K Logan B Winbery S | 2000 | Am J Emerg Med2000，18，5： | 1 |
| 4 | Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics 显示文摘 | Thangada S Khanna KM Blaho VA | 2010 | J Exp Med2010，207，： | 1 |
| 5 | Current and future options for treatment of osteoporosis 显示文摘 | BLAHOS J | 2011 | Vnitr Lek2011，57，11： | 1 |
| 6 | Current and future options for treatment of osteoporosis 显示文摘 | Blahos J | 2011 | Vnitr Lek2011，57，11： | 1 |
| 7 | Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2neurons显示文摘 | Wenthold RJ Petralia RS Blahos JII | 1996 | J Neurosci1996，16，6： | 1 |
| 8 | Regulation of mammalian physiolo- gy, development, and disease by the sphingosine 1- phosphate and lysophosphatidic acid receptors 显示文摘 | Blaho VA HIa T | 2011 | Chemical reviews2011，1111，10： | 1 |
| 9 | ICPO gene expression is a herpes simplex virus type 1 apoptotic trigger显示文摘 | Sanfilippo CM Blaho JA | | 0，，14： | 1 |
| 10 | Herpes simplex virus blocks apoptosis by precluding mitochondrial cytochrome c release independent of caspase activation in infected human epithelial cells显示文摘 | Aubert M Pomeranz LE Blaho JA | | 0，，： | 1 |
| 11 | Tympanic membrane perfo- ration:Complication of tympanic thermometry during general an- esthesia显示文摘 | Tabor MW Blaho DM Schriver WR | 1981 | Oral Surg Oral Med Oral Pathol1981，51，： | 1 |
| 12 | Cell-sur- face residence of sphingosine 1-phosphate receptor 1on lymphocytes determines lymphocyte egress kinetics 显示文摘 | Thangada S Khanna KM Blaho VA | 2010 | The Journal of experimental medicine2010，207，7： | 1 |
| 13 | Treatment and prevention of osteoporosis显示文摘 | Blahos J | | 0，，23： | 1 |
| 14 | Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity显示文摘 | Crouser ED Julian MW Blaho DV | 2002 | Crit Care Med2002，30，2： | 1 |
| 15 | Single-dose oral activated charcoal in the treatment of the self-poisoned patient:a prospective,randomized,controlled trial显示文摘 | Merigian KS Blaho KE | 2002 | Am J Ther2002，9，4： | 1 |
| 16 | The facts of death显示文摘 | Sanfilippo CM Blaho JA | 2003 | Intern Rev Immunol2003，22，32： | 1 |
| 17 | Casein kinase Ⅱ specifically nucleotidylylates in vitro the amino acid sequence of the protein encoded by the 22 gene of herpes simplex virus 1 显示文摘 | Mitchell C Blaho J A Roizman B | 1994 | Proc Natl Acad Sci USA1994，91，11： | 1 |
| 18 | Apoptosis during herpes simplex virus infection显示文摘 | Anguyen ML Blaho JA | 2007 | Adv Virus Res2007，69，： | 1 |
| 19 | Tympanic membrane perfora- tion~complication of tympanic thermometry during general anesthesia显示文摘 | Tabor MW Blaho DM Schriver WR | 1981 | Oral Surg Oral Med Oral Patbol1981，51，6： | 1 |
| 20 | The nucleotidylylation of herpes simplex virus 1 regulatory protein 22 by human casein kinase II 显示文摘 | Mitchell C Blaho J A McCormick A L | 1997 | J Biol Chem1997，272，25： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员