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| 1 | WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Neurotrauma and mesenchymal stem cells treatment:From experimental studies to clinical trials显示文摘Mesenchymal stem cell(MSC)therapy has attracted the attention of scientists and clinicians around the world.Basic and pre-clinical experimental studies have highlighted the positive effects of MSC treatment after spinal cord and peripheral nerve injury.These effects are believed to be due to their ability to differentiate into other cell lineages,modulate inflammatory and immunomodulatory responses,reduce cell apoptosis,secrete several neurotrophic factors and respond to tissue injury,among others.There are many pre-clinical studies on MSC treatment for spinal cord injury(SCI)and peripheral nerve injuries.However,the same is not true for clinical trials,particularly those concerned with nerve trauma,indicating the necessity of more well-constructed studies showing the benefits that cell therapy can provide for individuals suffering the consequences of nerve lesions.As for clinical trials for SCI treatment the results obtained so far are not as beneficial as those described in experimental studies.For these reasons basic and pre-clinical studies dealing with MSC therapy should emphasize the standardization of protocols that could be translated to the clinical set with consistent and positive outcomes.This review is based on pre-clinical studies and clinical trials available in the literature from 2010 until now.At the time of writing this article there were 43 and 36 pre-clinical and 19 and 1 clinical trials on injured spinal cord and peripheral nerves,respectively. | Ana Maria Blanco Martinez Camila de Oliveira Goulart Bruna dos Santos Ramalho Júlia Teixeira Oliveira Fernanda Martins Almeida | 2014 | World Journal of Stem Cells2014，6，2： | 11 |
| 2 | Blood pressure gradients in cerebral arteries:a clue to pathogenesis of cerebral small vessel disease显示文摘rationale The role of hypertension in cerebral small vessel disease is poorly understood.At the base of the brain(the‘vascular centrencephalon’),short straight arteries transmit blood pressure directly to small resistance vessels;the cerebral convexity is supplied by long arteries with many branches,resulting in a drop in blood pressure.Hypertensive small vessel disease(lipohyalinosis)causes the classically described lacunar infarctions at the base of the brain;however,periventricular white matter intensities(WMIs)seen on MRI and WMI in subcortical areas over the convexity,which are often also called‘lacunes’,probably have different aetiologies.Objectives We studied pressure gradients from proximal to distal regions of the cerebral vasculature by mathematical modelling.Methods and results Blood flow/pressure equations were solved in an Anatomically Detailed Arterial Network(ADAN)model,considering a normotensive and a hypertensive case.Model parameters were suitably modified to account for structural changes in arterial vessels in the hypertensive scenario.Computations predict a marked drop in blood pressure from large and medium-sized cerebral vessels to cerebral peripheral beds.When blood pressure in the brachial artery is 192/113 mm Hg,the pressure in the small arterioles of the posterior parietal artery bed would be only 117/68 mm Hg.In the normotensive case,with blood pressure in the brachial artery of 117/75 mm Hg,the pressure in small parietal arterioles would be only 59/38 mm Hg.conclusion These findings have important implications for understanding small vessel disease.The marked pressure gradient across cerebral arteries should be taken into account when evaluating the pathogenesis of small WMIs on MRI.Hypertensive small vessel disease,affecting the arterioles at the base of the brain should be distinguished from small vessel disease in subcortical regions of the convexity and venous disease in the periventricular white matter. | Pablo J Blanco Lucas O Müller J David Spence | 2017 | Stroke & Vascular Neurology2017，2，3： | 9 |
| 3 | Concentration versus non-concentrating reactors for solar photocatalytic degradation of p - nitrotoluene - o - sulfonic 显示文摘 | Para S malato S Blanco J | 2001 | Wat Sci Technol2001，44，5： | 2 |
| 4 | Chemical activation of carbon mesophase pitches 显示文摘 | MORA E BLANCO C PAJARES J A | 2006 | J Colloid Interface Sci2006，298，1： | 1 |
| 5 | Long-term results and survival rate of implants treated with guided bone regeneration: a 5-year case series prospective study显示文摘 | Blanco J Alonso A Sanz M | 2005 | Clin Oral hnplants Res2005，16，3： | 1 |
| 6 | Proteomic characterization of human normal articular chondrocytes: a novel tool for the study of osteoarthritis and other rheumatic diseases显示文摘 | Ruiz-Romero C Lopez-Armada M J Blanco FJ | 2005 | Proteomics2005，5，12： | 1 |
| 7 | The release of tumor necrosis factor-alpha is associated with ische mic tolerance in human stroke显示文摘 | Castillo J Moro MA Blanco M | 2003 | Ann Neurol2003，54，6： | 1 |
| 8 | The release of tumor necrosis factor-alpha is associated with ischemic tolerance in human stroke显示文摘 | Castillo J Moro MA Blanco M | 2003 | Ann Neurol2003，54，6： | 1 |
| 9 | Assessment of a new test to detect Legionella urinary antigen for the diagnosis of Legionnaires' disease显示文摘 | Dominguez J Gali N Blanco S | 2001 | Diagn Microbiol Infect Dis2001，41，4： | 1 |
| 10 | Ventilator-induced lung injury and sepsis : two sides of the same coin? 显示文摘 | Villar J Blanco J Zhang H | 2011 | Minerva Anestesiol2011，77，6： | 1 |
| 11 | System for eleavable Fc fusion proteins using tobacco etch virus (TEV) protease 显示文摘 | Haspel J Blanco C Jacob J Grumet M | 2001 | Biotechniques2001，30，1： | 1 |
| 12 | Pitch-based carbon com-posites with granular reinforcements for frictional applications显示文摘 | Blanco C Santamaría R Bermejo J | 2000 | Carbon2000，38，7： | 1 |
| 13 | The ALIEN study:in- cidence and outcome of acute respirator, distress syndrome in the era of lung protective ventilation 显示文摘 | VILLAR J BLANCO J ANON JM et at | 2011 | Intensive Care Med2011，37，12： | 1 |
| 14 | Urinary biomarkers in lupus nephritis显示文摘 | Reyes-Thomas J Blanco I Putterman C | 2011 | Clin Rev Allergy Immunol2011，40，3： | 1 |
| 15 | Procalcitonin,A new marker for bacterial infection显示文摘 | CasadO F J Blanco Q | 2001 | An Esp Pediatr2001，54，： | 1 |
| 16 | Magnetostriction in glass-coated magnetic microwires 显示文摘 | Zhukov A Zhukova V Blanco J M | 2003 | J Magn Magn Mater2003，258，： | 1 |
| 17 | Snail family members and cell survival in physiological and pathological cleft palates显示文摘 | MARTINEZ-ALVAREZ C BLANCO M J Perez R | 2004 | Dev Biol2004，265，1： | 1 |
| 18 | A tabu search algorithm for structural software testing显示文摘 | DIAZ E TUYA J BLANCO R | 2008 | Computers and Operations Research2008，35，10： | 1 |
| 19 | Honeycomb monoliths of activated carbons for effluent gas purification 显示文摘 | YATES M BLANCO J AVILA P | 2000 | Microporoas and Mesoporous Materials2000，37，1： | 1 |
| 20 | Chromosome segregation in a man heterozygous for a pericentric inversion, inv (9) ( pl I q13 ), analyzed by using sperm karyotyping and two - color fluorescence in situ hybridization on sperm nuclei 显示文摘 | Colls J Blanco O Marttnez - Pasarell F | 1997 | Hum Genet1997，99，： | 1 |
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