|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice显示文摘 | J. N. Boampong E. O. Ameyaw B. Aboagye K. Asare S. Kyei J. H. Donfack E. Woode Wej Choochote | 2013 | <journal-title>Journal of Parasitology Research2013，，： | 1 |
| 2 | In vivo antiplasmodial and in vitro antioxidant property of stem bark extracts of Haematostaphis barteri显示文摘Objective: To evaluate the antimalarial and antioxidant properties of stem bark extracts of Haematostaphis barteri(H. barteri).Methods: The prophylactic activity of the plant was performed by dosing mice with sulfadoxine-pyrimethamine(1.2 mg/kg), aqueous extract(30, 100, 300 mg/kg) and dichloromethane/methanol(D/M)(30, 100, 300 mg/kg) extracts of H. barteri for 3 days. On the 4th day, the mice were inoculated with Plasmodium berghei. The parasite density was estimated for each mouse 72 h post-parasite inoculation. The curative activity of the plant was also performed by inoculating mice with Plasmodium berghei. Three days later, they were treated with artemether-lumefantrine(4 mg/kg), aqueous and D/M extracts of H. barteri stem bark for 5 days. The in vitro antioxidant property of the aqueous extract was determined by using the reducing power, nitric oxide and total antioxidant capacity assays. Results: The aqueous extract exerted significant(P < 0.05) curative and prophylactic antimalarial activities. The D/M extract exhibited significant curative(P < 0.05) but not prophylactic antiplasmodial ef ect. The aqueous extract exhibited in vitro antioxidant property with IC50's of(0.930 ± 0.021) mg/mL,(0.800 ± 0.001) mg/mL and(0.22 ± 0.05) mg/mL in the total antioxidant capacity, reducing power and nitric oxide assays. Histological assessment of the liver of aqueous and D/M treated animals did not reveal any sign of toxicity.Conclusions: H. barteri is not toxic which exerted significant curative antiplasmodial ef ects but the prophylactic property was however fraction dependent. The mechanism of the antiplasmodial activity of H. barteri may partly be mediated by its antioxidant property. | Johnson Nyarko Boampong Akua Afryie Karikari Elvis Ofori Ameyaw | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，6： | 0 |
| 3 | Effect of pre-existing Schistosoma haematobium infection on Plasmodium berghei multiplications in imprinting control region mice显示文摘Objective: To investigate the effect of pre-existing Schistosoma haematobium(S. haematobium) infection on malaria disease severity.Methods: The study involved the use of twenty-i ve imprinting control region mice, i fteen of which were initially infected with S. haematobium. Five of the remaining ten schistouninfected mice together with i ve schisto-infected mice were infected with Plasmodium berghei(P. berghei) after four weeks(acute stage) of schistosoma infection. The remaining i ve schisto-uninfected mice together with i ve schisto-infected mice were also infected with P. berghei after seven weeks(chronic stage) of schistosoma infection. The last i ve schistoinfected mice were used as control group. They were then monitored for changes in P. berghei parasitaemia on Days 3, 5, 7, 9 and 11 post-infection. Records on their survivability were also taken.Results: The co-infected mice had signii cantly higher malaria parasitaemia, compared with the mono-infected mice during acute S. haematobium infection. In contrast, the co-infected mice had signii cantly lower malaria parasitaemia during chronic S. haematobium infection and a higher survival rate.Conclusions: Co-infection of mice with P. berghei during acute S. haematobium infection resulted in rapid P. berghei development and increased malaria parasitaemia. However, the co-infection resulted in slower P. berghei development and decreased malaria parasitaemia with enhanced survivability of the mice during chronic S. haematobium infection. Therefore, pre-existing chronic S. haematobium infection may provide some protection to the host by reducing parasitaemia. | Benjamin Amoani Elvis Ofori Ameyaw Du-Bois Asante Francis Ackah Armah James Prah Collins Paa Kwesi Botchey Johnson Nyarko Boampong | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，6： | 0 |
| 4 | Forensic Identification of Missing Persons using DNA from Surviving Relatives and Femur Bone Retrieved from Salty Environment显示文摘Human identification using forensic DNA profiling has made enormous advancement over the past two‑and‑half decades.Forensic DNA profiling provides enormous genetic data from a variety of biological materials and individualsto help solve many important criminal and civil cases that confront society.Under certain environmental conditions,the total deterioration of soft-tissue leaves skeletal remains as the only available sample for DNA testing to identify missing persons,victims of natural disasters,or exonerate suspect(s)in a criminal case.We report the findings of a case involving the human remains of a missing person submitted to the Forensic Science Laboratory of the Ghana Police Service for forensic DNA profiling in comparison to an alleged living relative of the deceased.DNA from the femur bone and buccal swabs of alleged relative of the deceased were extracted,quantified,and short tandem repeat(STR)profiled using Qiagen’s Investigator kit,Applied Biosystem’s Quantifiler trio,and GlobalFiler kits.Full STR profiles were generated for both the femur bone from the salty environment and the buccal swabs from the alleged relative.The femur bone was genetically identified to be that of the missing person.The remains were thus handed over to the relatives for final funeral rites and burial to bring closure to the long search for the missing person. | Kofi Adjapong Afrifah Alexander Badu‑Boateng Samuel Antwi‑Akomeah Eva Emefa Motey Emmanuel Boampong Peter Twumasi Paul Poku Sampene Augustine Donkor | 2020 | Journal of Forensic Science and Medicine2020，6，1： | 0 |
| 5 | Evaluation of sour gas-low salinity waterflooding in carbonate reservoirs-A numerical simulation approach显示文摘Although significant amount of H_(2)S(sour gas)rich natural gas is estimated globally,but not much attention has been given to the application of H_(2)S in the oil recovery process.Recent studies on the use of H_(2)S in oil recovery processes showed that H_(2)S has the potential of improving the oil recovery,and it can be even more effective than using CO_(2) in some processes.H_(2)S can equally dissolve in the water,react with the reservoir rock to change its surface charge,porosity,and permeability.However,previous in-vestigations on H_(2)S oil recovery attributed the improved oil recoveries to the higher miscibility of H_(2)S in the oil,and the reduction in the oil viscosity.Therefore,there is limited understanding on the H_(2)S-oil-brine-rock geochemical interactions,and how they impact the oil recovery process.This study aims to investigate the interactions between H_(2)S,oil,and carbonate formations,and to assess how the combi-nation of H_(2)S and low salinity water can impact the wettability and porosity of the reservoirs.A triple layer surface complexation model was used to understand the influence of key parameters(e.g.,pressure,brine salinity,and composition)on the H_(2)S-brine-oil-rock interactions.Moreover,the effects of mineral content of the carbonate rock on H_(2)S interactions were studied.Thereafter,the results of the H_(2)S-oil-brine-rock interactions were compared with a study where CO_(2) was used as the injected gas.Results of the study showed that the seawater and its diluted forms yielded identicalζ-potential values of about 3.31 mV at a pH of 3.24.This indicates that at very low pH condition,pH controls the ζ-potential of the oil-brine interface regardless of the brine's ionic strength.The study further demonstrated that the presence of other minerals in the carbonate rock greatly reduced the calcite dissolution.For instance,the calcite dissolution was reduced by 4.5%when anhydrite mineral was present in the carbonate rock.Findings from the simulation also indicated that CO_(2) produced negative ζ-potential values for the car-bonate rocks,and these values were reduced by 18.4%-20% when H_(2)S was used as the gas phase.This implies that the H_(2)S shifted the carbonate rockζ-potentials towards positive.The outcomes of this study can be applied when designing CO_(2) flooding and CO_(2) storage where the gas stream contains H_(2)S gas since H_(2)S greatly influences the dissolution of the carbonate mineral. | Lawrence Opoku Boampong Roozbeh Rafati Amin Sharifi Haddad | 2023 | Petroleum Research2023，8，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员