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| 1 | Increased plasma malondialdehyde and fructosamine in anemic H pylori infected patients:Effect of treatment显示文摘AIM: To unravel the possible association of malon-dialdehyde (MDA) and fructosamine in anemic H pylori infected patients and to observe the alteration in MDA and fructosamine levels in these patients after treatment for one month.METHODS: Fructosamine, MDA and glucose were estimated in 22 anemic H pylori infected patients and 16 healthy controls. Hematological parameters were also evaluated in both the groups using Sysmex-K-100 automated cell counter. The H pylori infected patients were randomly divided into two groups. H pylori infected patients in GroupⅠreceived both iron supplementation and anti-H pylori therapy, while patients in Group Ⅱ received only iron supplementation. All the biochemical and hematological parameters were estimated after one month of treatment. RESULTS: In anemic H pylori infected patients, while MDA (5.41 ± 2.16 vs 2.26 ± 0.50; P < 0.05) and fructosamine (2.64 ± 0.93 vs 1.60 ± 0.35; P < 0.05) were significantly increased, iron (32.72 ± 14.93 vs 110.25 ± 26.58; P < 0.05), hemoglobin (6.9 ± 2.6 vs 12.66 ± 0.74; P < 0.05) and ferritin (28.82 ± 16.27 vs 140.43 ± 30.72; P < 0.05) levels were significantly decreased compared with the controls. With partial correlation analysis, fructosamine was found to have a significant positive correlation with MDA. In GroupⅠ, while MDA level decreased significantly (3.11 ± 1.73 vs 5.50 ± 2.46; P < 0.05), there was a significant increase in iron (84.09 ± 29.51 vs 36.09 ± 17.81; P < 0.05), hemoglobin (10.40 ± 1.11 vs 7.42 ± 1.90; P < 0.05) and ferritin (116.91 ± 63.34 vs 30.46 ± 17.81; P < 0.05) levels after one month. There was no significant change in the levels of fructosamine in groupⅠafter treatment. Similarly, no significant alterations were noted in the levels of MDA, fructosamine, hemoglobin or ferritin in Group Ⅱ patients after one month of treatment.CONCLUSION: An increased level of fructosamine and MDA was found in anemic H pylori infected patients. Present data supports the premise that lipid peroxides per se do play a role in the glycation of plasma proteins. Furthermore, the findings from this study indicate that treatment for both anemia and H pylori infections is required for lowering the levels of lipid peroxides in these patients. | G Vijayan RC Sundaram Zachariah Bobby Abdoul Hamide N Selvaraj N Rattina Dasse | 2007 | World Journal of Gastroenterology2007，13，5： | 4 |
| 2 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 3 | Arginine and immunity: a unique perspective 显示文摘 | CARMELO N J BOBBI L H | 2002 | Biomed Pharmacother2002，56，10： | 1 |
| 4 | Vitamin E protects the insulin sensitivity and redox balance in rat L6 muscle cells exposed to oxidative stress显示文摘 | Vinayaga M R Bobby Z Selvaraj N | 2006 | Clin Chim Acta2006，367，12： | 1 |
| 5 | Increased protein glycation in non-diabetic pediatric nephrotic syndrome: Possible role of lipid peroxidation显示文摘 | Bobby Z Selvaraj N | 2003 | Clin Chim Acta2003，337，12： | 1 |
| 6 | Increased glyca- tion of hemoglobin in chronic renal failure: Ecorrected potential role of oxidative stress显示文摘 | Selvaraj N Bobby Z Sridhar MG | 2008 | ArchMed Res2008，39，3： | 1 |
| 7 | Association between oxidative stress and coronary lipid risk factors in hypothyroid women is independent of body mass index显示文摘 | Nanda N Bobby Z Hamide A | 2007 | Metabolism2007，56，10： | 1 |
| 8 | Association be- tween oxidative stress and coronary lipid risk tatctors in hypothyroidwomen is independentof bodymass index 显示文摘 | Nanda N Bobby Z Hamide A | 2007 | Metabolism2007，56，10： | 1 |
| 9 | High energy electron beam for ceramic in joining显示文摘 | Turman Bobby N | 1995 | Proceedings of SPIE-The International Society for Optical Engineering1995，23，74： | 1 |
| 10 | An evaluation of thy- roid hormone status and oxidative stress in undialyzed chronic renal failure patients 显示文摘 | Singh PA Bobby Z Selvaraj N | 2006 | Indian J Physiol Pharmacol2006，50，3： | 1 |
| 11 | Vitamin E protects the insulin sensitivity and redox balance in rat L6 muscle cell exposed to oxidative stress显示文摘 | Moorthi VR Bobby Z Selvaraj N | 2006 | Clin Chim Acta2006，367，12： | 1 |
| 12 | Oxidative stress:does it play a role in the genesis of early glycated proteins显示文摘 | Selvaraj N Bobby Z Sridhar MG | 2008 | Med Hypotheses2008，70，2： | 1 |
| 13 | Increased protein glyca- fion in non -diabetic pediatric nephrotic syndrome: Possible role of lipid peroxi - dation显示文摘 | Balamumgan R Bobby Z Selvaraj N | 2003 | Clin Chin Acta2003，337，12： | 1 |
| 14 | Methods for controlling catalase in a deinking pulp mill显示文摘 | Bobby N G Dan Davies | 1997 | TAPPI1997，，： | 1 |
| 15 | Arginine and immunity: a unique perspective显示文摘 | Carmelo N J Bobbi L- H | 2002 | Biomed Pharmaeother2002，56，： | 1 |
| 16 | Association between oxidatives tress and corunary lipid risk factors in hypothyroid women is indepen- dent of body mass index显示文摘 | Nanda N Bobby Z Hamide A | 2007 | M etab olism2007，56，10： | 1 |
| 17 | An evaluation of thyrok] hormone status and oxidative stress in undialyzed chronic renal failure patients 显示文摘 | Singh PA Bobby Z Selvaraj N | 2006 | Indian J Physiol Phar- macol2006，50，3： | 1 |
| 18 | An evaluation of thyroid hormonestatus and oxidative stress in undialyzed chronic renal failure patients显示文摘 | Singh PA Bobby Z Selvaraj N | 2006 | Indian J Physiol Pharmacol2006，50，： | 1 |
| 19 | Cost effective treatment of organic sludge in a HRB 显示文摘 | Dhuldhoya N Lamen J Bobby Martinetal | 1996 | Environmental Progress1996，16，2： | 1 |
| 20 | Vitamin E protects the insulin sensitivity and redox balance in rat L6 muscle cells exposed to oxidative stress 显示文摘 | MOORTHI R V BOBBY Z SELVARJ N | 2006 | Clinica Chim Acta2006，367，12： | 1 |
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