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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	Interacting multiple model particle filter显示文摘	BOERS Y DRIESSEN J N	2003	Radar Sonar and Navigation IEE Proceedings2003，150，5：	1
3	Hybrid state estimation:a target tracking application显示文摘	Boers Y Driessen H	2002	Automatica2002，38，12：	1
4	Alopecia mucinosa is mycosis fungoides 显示文摘	Boer A Guo Y Ackerman AB	2004	Am J Dermatopathol2004，26，1：	1
5	Gaussian proposal density using moment matching in SMC methods显示文摘	Saha S Mandal P K Boers Y	2008	Statistics and Computing2008，19，2：	1
6	Gaussian proposal density using moment matching in SMC methods 显示文摘	SAHA S MANDAL P K BOERS Y	2008	Statistics and Comput- ing2008，19，2：	1
7	Interacting Multiple Model Particle Filter显示文摘	Boers Y Driessen J N	2003	IEE Proc of Radar Sonar Navigation2003，150，5：	1
8	Interacting multiple model particle filter显示文摘	Boers Y Driessen J N	2003	IEE Proc of Radar Sonar Navigation2003，150，5：	1
9	Interacting multiple model particle filter显示文摘	Y BOERS J N DRIESSEN	2003	IEE Process Radar Sonar Navigation2003，150，5：	1
10	Particle filter based detection for tracking显示文摘	Boers Y Driesen J N	2003	IEEE SP Letters2003，10，10：	1
11	A particle-filter-based detection scheme显示文摘	Boers Y Driessen H	2003	IEEE Signal Processing Letters2003，10，10：	1
12	Results on the modified Riccatiequation:target tracking applications显示文摘	Boers Y Driessen H	2006	IEEE Transac-tions on Aerospace and Electronic Systems2006，42，1：	1
13	Genome sequence and analysis of the tuber crop potato显示文摘	Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G	2011	Nature2011，475，7355：	1
14	Temporal trends in the prevalence of diabetic kidney disease in the United States 显示文摘	De Boer I Rue T Hall Y	2011	JAMA2011，305，：	1
15	High-frequency electromotile responses in the cochlea显示文摘	Grosh K Zheng J Zou Y de Boer E Nuttall AL		0，，：	1
16	Frpl is a Fusarium oxysporum F-box protein required for patho- genicity on tomato显示文摘	Duyvesteijn R G van Wijk R Boer Y	2005	Mol Microbiol2005，57，：	1
17	Multitarget particle filter track heft)re detect application 显示文摘	Boers Y Driessen H	2004	IEE Proceedings of Radar ~nar Navi- gation2004，151，6：	1
18	Interacting multiple model particle filter 显示文摘	BOERS Y DRIESSEN J N	2003	IEEE Proceedings of Radar Sonar navigation2003，150，5：	1
19	Results on the modified Riccati equation :target tracking applications 显示文摘	BOERS Y DRIESSEN H	2006	IEEE Transactions on Aerospace and Electronic Systems2006，42，1：	1
20	Track - 显示文摘	Boers Y Dries~n H Torstelrsss~n J	2006	lEE IM~ceedings of Radar Sonar Navigation2006，153，4：	1

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