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3篇 您的检索式：作者名="Bogyo Matthew"

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		题名	作者	年代	出处	被引量
	1	Development of Small Molecule Inhibitors and Probes of Human SUMO Deconjugating Proteases显示文摘	Victoria E. Albrow Elizabeth L. Ponder Domenico Fasci Miklós Békés Edgar Deu Guy S. Salvesen Matthew Bogyo	2011	Chemistry & Biology2011，，6：	1
	2	Identification of a myeloid-derived suppressor cell cystatin-like protein that inhibits metastasis显示文摘	Boutté AM Angela M Friedman David B Bogyo Matthew	2011	Faseb J2011，25，8：	1
	3	Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity显示文摘Dear Editor:Caspase regulation and activation have been extensivelystudied since the discovery of this class of proteases almosttwo decades ago, yet surprisingly few tools are availablethat can be used to monitor individual caspase activities[1]. The most commonly used tools include caspase-specificanti-sera as well as fluorogenic substrates and inhibitors.Unfortunately, antibody reagents often do not provide anaccurate measure of caspase activity since several caspasefamily members (caspases 8/10 and 9) do not require pro-teolytic processing for activation [2,3].Furthermore,recentevidence suggests that caspase-7(an executioner caspase)activation occurs via a catalytically active full-length inter-mediate that cannot be differentiated from the non-cleavedinactive zymogen using antibodies[4,5].As an alternative to antibody-based reagents,smallmolecule substrates and inhibitors can be used to directlymonitor caspase activity and a relatively large number ofcaspase substrates,inhibitors,and activity-based probes arenow commercially available.These reagents have begunto find widespread use in cell biological and biochemicalstudies of caspase function.In most cases,these tools areused as selective reagents to assess the contribution ofspecific caspases to a given apoptotic pathway.	Alicia B Berger Kelly B Sexton Matthew Bogyo	2006	Cell Research2006，16，12：	1

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