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| 1 | Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients显示文摘AIM: To assess pre-orthotopic liver transplantation (OLT) factors that could be evaluated pre-operatively or con- trolled post-operatively associated with hepatocellular carcinoma (HCC) recurrence and disease-free survival after liver transplantation (LT).METHODS: Four hundred and twelve patients trans- planted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to iden- tify independent predictors of recurrence. RESULTS: Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were: presence of cirrhosis (P = 0.001), etiology of liver disease (P = 0.03), α fetoprotein level (< 200, 200 to 2000, or > 2000; P < 0.0001), γ-GT activity (N, N to 2N or > 2N; P = 0.02), the number of nodules (1, 2-3 or ≥ 4; P = 0.02), maximal diameter of the largest nodule (< 3 cm, 3 to 5 cm or > 5 cm; P < 0.0001), the sum of the diameter of the nodules (< 3 cm, 3 to 5 cm, 5 to 10 cm or >10 cm; P < 0.0001), bi- lobar location (P = 0.01), preoperative portal thrombosis (P < 0.0001), peri-operative treatment of the tumor (P = 0.002) and chemoembolization (P = 0.03), tumor differentiation (P = 0.01), initial type of calcineurin inhibitor (P = 0.003), the use of antilymphocyte antibodies (P = 0.02), rejection episodes (P = 0.003) and period of LT (P < 0.0001). By multivariate analysis, 6 variables were independently associated with HCC recurrence: maximal diameter of the largest nodule (P < 0.0001), time of LT (P < 0.0001), tumor differentiation (P < 0.0001), use of anti-lymphocyte antibody (ATG) or anti-CD3 antibody (OKT3) (P = 0.005), preoperative portal thrombosis (P = 0.06) and the number of nodules (P = 0.06). CONCLUSION: This study identif ies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recurrence, and confi rms the prognostic value of tumor differentiation. | Thomas Decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole Meyer Jean Gugenheim Francois Durand Pierre-Henri Bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian Ducerf Georges Philippe Pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux | 2006 | World Journal of Gastroenterology2006，12，45： | 10 |
| 2 | Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution显示文摘AIM: To investigate the benefits of insulin like growth factor-1 (IGF-1) supplementation to serum-free institut georges lopez-1 (IGL-1) solution to protect fatty liver against cold ischemia reperfusion injury. METHODS: Steatotic livers were preserved for 24 h in IGL-1 solution supplemented with or without IGF-1 and then perfused 'ex vivo ' for 2 h at 37℃. We examined the effects of IGF-1 on hepatic damage and function (transaminases, percentage of sulfobromophthalein clearance in bile and vascular resistance). We also studied other factors associated with the poor tolerance of fatty livers to cold ischemia reperfusion injury such as mitochondrial damage, oxidative stress, nitric oxide, tumor necrosis factor-α (TNF-α) and mitogen-activated protein kinases.RESULTS: Steatotic livers preserved in IGL-1 solutionsupplemented with IGF-1 showed lower transaminase levels, increased bile clearance and a reduction in vascular resistance when compared to those preserved in IGL-1solution alone. These benefits are mediated by activation of AKT and constitutive endothelial nitric oxide synthase (eNOS), as well as the inhibition of inflammatory cytokines such as TNF-α. Mitochondrial damage and oxidative stress were also prevented.CONCLUSION: IGL-1 enrichment with IGF-1 increasedfatty liver graft preservation through AKT and eNOS activation, and prevented TNF-α release during normothermic reperfusion. | Mohamed Amine Zaouali Susagna Padrissa-Altés Ismail Ben Mosbah Hassen Ben Abdennebi Olivier Boillot Antoni Rimola Dalila Saidane-Mosbahi Joan Roselló-Catafau | 2010 | World Journal of Gastroenterology2010，16，45： | 6 |
| 3 | Evaluation of IGL-1 preservation solution using an orthotopic liver transplantation model显示文摘AIM: To compare, in a pig liver transplantation model, the protective effect of UW with that of IGL-1, a high-sodium preservation solution containing polyethylene glycol (PEG) as an oncotic supply. METHODS: All livers were harvested and grafted orthotopically according to standard techniques. The livers were washed out and preserved for 7 h in IGL-1 (n = 6) or in UW solution (n = 7) at 4℃. In a sham group (n = 4), the livers underwent a 60-min warm ischemia at 37℃. The hepatocellular injury was assessed in organ preservation solution washed out from the graft at the end of ischemic storage (before revascularization), and in serum 2 h after reperfusion and daily for up to 6 d. RESULTS: Livers preserved in IGL-1 solution released markedly less AST than that preserved in the UW solution before and after revascularization (P < 0.05). Besides, the activity of creatine kinase-BB, a marker of sinusoidal lining cells injury, was higher in the UW group than in the IGL-1 group (P < 0.05). Histological results showed less necrotic regions in livers preserved in IGL-1 solution; however, no difference was observed for in? ammation. CONCLUSION: IGL-1 liquid effectively protects parenchymal and non-parenchymal cells against prese-rvation-reperfusion injuries. | Hassen Ben Abdennebi Ziad Elrassi Jean-Yves Scoazec Jean-Paul Steghens Silvina Ramella-Virieux Olivier Boillot | 2006 | World Journal of Gastroenterology2006，12，33： | 5 |
| 4 | Liver Transplantation for Neuroendocrine Tumors in Europe—Results and Trends in Patient Selection: A 213-Case European Liver Transplant Registry Study显示文摘 | Yves Patrice Le Treut Emilie Grégoire Jürgen Klempnauer Jacques Belghiti Elisabeth Jouve Jan Lerut Denis Castaing Olivier Soubrane Olivier Boillot Georges Mantion Kia Homayounfar Manuel Bustamante Daniel Azoulay Philippe Wolf Marek Krawczyk Andreas Pasche | 2013 | Annals of Surgery2013，，5： | 3 |
| 5 | 智能视觉技术在焊接系统中的应用显示文摘介绍了最新的激光视觉传感技术在机器人焊缝搜索定位、机器人或专机自动化焊缝跟踪及智能化激光焊接系统中的应用。设计的Sense-I/D和SF/D传感器能实现快速精确地搜索定位焊缝,而且能最大限度地减少对焊枪可达性的影响;先进的Mini-I/D激光传感系统可以简单而可靠地实现焊缝跟踪,在焊接中能够根据所测量的间隙和错边等数据实时地调整焊接过程参数;Digi-Las数字激光焊接头包含了焊缝搜索位、焊缝跟踪、焊接参数自适应控制及焊缝成形和表面缺陷检测功能。应用适合焊接的智能化激光视觉传感技术,可提高焊接质量和生产效率,降低焊接生产成本,有效提高焊接产品质量和价格的竞争力。 | 陈志翔 Jean-Paul Boillot | 2010 | 电焊机2010，40，6： | 3 |
| 6 | Natural history, treatment and prevention of hepatitis C recurrence after liver transplantation: Past, present and future显示文摘Hepatitis C virus(HCV)-related liver disease, including cirrhosis and hepatocellular carcinoma is the main indication for liver transplantation(LT) worldwide. Posttransplant HCV re-infection is almost universal and results in accelerated progression from acute hepatitis to chronic hepatitis, and liver cirrhosis. Comprehension and treatment of recurrent HCV infection after LT have been major issues for all transplant hepatologists and transplant surgeons for the last decades. The aim of this paper is to review the evolution of our knowledge on the natural history of HCV recurrence after LT, including risk factors for disease progression, and antiviral therapy. We will focus our attention on possible ways(present and future) to improve the final longterm results of LT for HCV-related liver disease. | Jérme Dumortier Olivier Boillot Jean-Yves Scoazec | 2014 | World Journal of Gastroenterology2014，20，32： | 2 |
| 7 | DIGI-LAS激光焊接头在汽车及航空航天部件焊接中的应用显示文摘随着汽车、航空航天等行业激光焊接应用的发展,含有非平行直线或曲线焊缝的剪裁激光拼焊板件快速增长,柔性的机器人激光焊应用也随之增加。但目前的大多数关节式工业机器人尚难以有效地追踪重复性不足的焊缝。集成了激光视觉传感的DIGI-LAS激光焊接头系统特别适合这些机器人或专机的激光焊应用。DIGILAS系统配置了2个激光传感器,一个用于焊前搜索、定位焊缝及焊缝跟踪,另一个用于实时检测焊缝,包括焊缝的成形尺寸和探测表面缺陷。此外,DIGI-LAS的激光传感器能够记录机器人追踪焊缝的误差,在焊接时给予补偿,保证了机器人系统可以满足激光焊的精度要求。经过补偿后,在超过6 m/min的焊接速度下,系统追踪曲率半径为50 mm的曲线焊缝的对中误差小于100μm。检测结果通过数字IO输出到机器人、PLC或外部的质量管理系统。自动的焊接质量检测有助于用户实现6σ的质量控制与管理。 | 陈志翔 Jean-Paul Boillot Jeff Noruk | 2009 | 焊接2009，，5： | 2 |
| 8 | 智能化和自动化技术在造船焊接中的应用(英文)显示文摘造船焊接中,焊接工艺需要优化以提高产量,同时,满足焊接标准的质量要求。然而,既使最成熟的焊接工艺,焊工所焊接操作等在其焊接准备阶段也无法“尽善尽美”。讨论了在焊前、焊中、焊后如何使用新型自动焊接设备,以减少工艺的不确定性。减少不确定性就意味着高水平的生产和质量。智能传感技术已应用于自动化程度不同的焊接设备中,如机械化、自动化机械设备和机器人,因其柔性化和轻便化而用于多任务的自动化焊接。并给出了应用实例。 | Jeffrey Noruk Jean-Paul Boillot Randy Li | 2007 | 电焊机2007，37，6： | 2 |
| 9 | Small-for-size partial liver graft in an adult recipient; a new transplant technique显示文摘 | Olivier Boillot Bertrand Delafosse Isabelle Méchet Catherine Boucaud Michel Pouyet | 2002 | The Lancet . 2002 (9304)2002，，9304： | 2 |
| 10 | Surgical technique of left lateralateral hepatic lobectomy in a related living donor for pediatric transplantation显示文摘 | Boillot O Voiglio E Dawahra M | 2000 | Transplant Proc2000，27，： | 1 |
| 11 | Corticosteroid-free immunosuppression with tacrolimus following induction with daclizumab= a large randomized clinical study 显示文摘 | Boillot O Mayer DA Boudjema K | 2005 | Liver Transpl2005，11，1： | 1 |
| 12 | Diagnosis and treatment of biliary obstruction caused by portal cavernoma显示文摘 | Dumortier J Vailant E Boillot O | 2003 | Endoscopy2003，35，5： | 1 |
| 13 | Adult left liver transplantation from split livers and living donors: a 14-year single-center experience显示文摘 | Boillot O Sagnard P Guillaud O | 2013 | Clin Transplant2013，27，4： | 1 |
| 14 | Pure laparoscopic left lateral sectionectomy in living donors: from innovation to development in France 显示文摘 | Scatton O Katsanos G Boillot O | 2015 | Ann Surg2015，261，3： | 1 |
| 15 | Place of the ureteroscopy in the treatment of the children urolithiasis显示文摘 | FOTSO K A TEKAILI BOILLOT B | 2010 | Prog Urol2010，20，3： | 1 |
| 16 | Controlled liver split- ting for transplantation in two recipients: technique, results and perspectives显示文摘 | Houssin D Boillot O Soubrane O | 1993 | Br J Surg1993，80，： | 1 |
| 17 | Effects of propofol on vascular reactivity in isolated aortae from normotensive and spontaneously hypertensive rats显示文摘 | Boillot A Laurant P Berthelot A | 1999 | Br J Anaesth1999，83，4： | 1 |
| 18 | External validation of the RENAL nephrometry score in renal tumours treated by partial nephrectomy显示文摘 | Jean‐Alexandre Long Valentin Arnoux Gaelle Fiard Riccardo Autorino Jean‐Luc Descotes Jean‐Jacques Rambeaud Bernard Boillot Nicolas Terrier Alexis Arvin‐Berod Alexandre Moreau‐Gaudry | 2012 | BJU Int2012，，： | 1 |
| 19 | Low rejection rates with tacrolimus-based dual and triple regimens following liver transplantation显示文摘 | Boillot O Baulieux J Wolf P | 2001 | Clin Transplant2001，15，3： | 1 |
| 20 | Adaptive welding by filter optic thermographic settling:An analysis of thermal and instrumental considerations显示文摘 | Boillot J P | 1985 | Welding Journal1985，64，7： | 1 |
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