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| 1 | Exercise manual for liver disease patients显示文摘AIM: To increase inspiratory muscle strength and improve the quality of life of candidates for liver transplantation.METHODS: Twenty-three candidates for liver transplantation participated in the control group and 14 made up the intervention group. The control group consisted of 18 men and 5 women, body mass index(BMI) 27.3 ± 4.5 kg/m2 and Model for End-Stage Liver Disease(MELD) 18.2 ± 6.1. The intervention group consisted of 11 men and 3 women, BMI 28.6 ± 5.4 kg/m2 and MELD 18 ± 4.5. The presence or absence of ascites was identified in the first patient evaluation and after three months. We evaluated maximal inspiratory pressure(MIP) and maximal expiratory pressure, spirometry, root mean square(RMS) of diaphragm and rectus abdominis, and the quality of life. The exercises were performed daily by patients at home for three months and were supervised at distance monthly. The manual consisted of diaphragmatic breathing exercises, diaphragmatic isometric exercise, Threshold IMT®, lifting upper limbs with a bat and strengthening the abdomen. RESULTS: There was significant difference(P = 0.01) between the first(initial) and the third month(final) MIP in the control group and in the intervention group, but there was no difference(P = 0.45) between the groups.The RMS of the diaphragm was lower(P = 0.001) and the functional capacity was higher(P = 0.006) in the intervention group compared to the control. The general health and mental health domains received higher scores after three months in the control group(P = 0.01) and the intervention group(P = 0.004), but there was no significant difference between them. The comparison between the presence of initial ascites with the presence of ascites was performed after three months in the control group(P = 0.083) and intervention group(P = 0.31). There was no significant difference, in relation to the presence of ascites after three months between groups(P = 0.21). In the intervention group, patients with ascites at the end of the time period had decreased scores on the social aspects SF-36 domain(P = 0.023) compared to those who had no ascites. CONCLUSION: The proposed exercises provide an increase in the inspiratory muscle strength and improve functional capacity, consequently bettering the quality of life of liver disease patients. | Vivian Limongi Daniele Costa Dos Santos Aurea Maria de Oliveira da Silva Ilka de Fátima Santana Ferreira Boin Raquel Silveira Bello Stucchi | 2016 | World Journal of Transplantation2016，6，2： | 3 |
| 2 | Immunotherapy of systemic sclerosis显示文摘 | Manno R Boin F | 2010 | Immunotherapy2010，2，： | 1 |
| 3 | The application of MELD score in patients submitted to liver transplantation:a retrospective analysis of survival and the predictive factors in the short and long term显示文摘 | Boin Ide F Leonardi MI Udo EY | 2008 | Arq Gastroenterol2008，45，4： | 1 |
| 4 | Association between -G308A tumor necrosis factor alpha gene polymorphism and schizophrenia显示文摘 | Boin F Zanardini R Pioli R | 2001 | Mol Psychiatry2001，6，1： | 1 |
| 5 | Association between promoter polymorphic haplotypes of Interleukin-10 gene and schizophrenia显示文摘 | Chiavetto LB Boin F Zanardini R | 2002 | Biol Psychiatry2002，51，6： | 1 |
| 6 | Association between-G308A tumor necrosis factor alpha gene polymorphism and schizophrenia显示文摘 | Boin F Zanardini R Pioli R | | 0，，01： | 1 |
| 7 | T cell polarization identifies distinct clinical phenotypes in scleroderma lung disease显示文摘 | Boin F De FU Bartlett SJ | 2008 | Arthritis Rheum2008，58，4： | 1 |
| 8 | Immunotherapy of systemic sclerosis显示文摘 | Manno R Boin F | 2010 | Immun- otherapy2010，2，： | 1 |
| 9 | Association between-G308A tumor necrosis factor alpha gene polymorphism and schizophrenia显示文摘 | Boin F Zanardini R Pioli R | 2001 | Mol Psychiatry2001，6，1： | 1 |
| 10 | Association between pro- moter polymorphic haptotypes of interleukin-10 gene and schizophre- nia 显示文摘 | Chiavetto L B Boin F Zanardini R | 2002 | Biol Psychiat2002，51，6： | 1 |
| 11 | Association between-G308A tumor necrosis factor alpha gene polymorphism and schizophrenia 显示文摘 | Boin F Zanardini R Pioli R | 2001 | Mol Psychiatry2001，6，1： | 1 |
| 12 | Development of donor - specific microchimerism in liver transplant recipient with HLA - DRBI and DQB1 mismatch related to rejection episodes 显示文摘 | Araujo MB Leonardi LS Boin I F | 2004 | Transplant Proc2004，36，4： | 1 |
| 13 | T cell polarization identiies distinct clinical phenotypes in scleroderma lung disease显示文摘 | Boin F De Fanis U Bartlett S l | 2008 | Arthritis Rheum2008，58，4： | 1 |
| 14 | Determination of continuous changes in the gel layer thickness of PEO and HPMC tablets undergoing hydration: a texture analysis study显示文摘 | Libo Y Boine J Reza F | 1998 | Pharm Res1998，15，12： | 1 |
| 15 | Hepatobiliary phases in magnetic resonance imaging using liverspecific contrast for focal lesions in clinical practice显示文摘BACKGROUND Challenging lesions,difficult to diagnose through non-invasive methods,constitute an important emotional burden for each patient regarding a still uncertain diagnosis(malignant x benign).In addition,from a therapeutic and prognostic point of view,delay in a definitive diagnosis can lead to worse outcomes.One of the main innovative trends currently is the use of molecular and functional methods to diagnosis.Numerous liver-specific contrast agents havebeen developed and studied in recent years to improve the performance of liver magnetic resonance imaging(MRI).More recently,one of the contrast agents introduced in clinical practice is gadoxetic acid(gadoxetate disodium).AIM To demonstrate the value of the hepatobiliary phases using gadoxetic acid in MRI for the characterization of focal liver lesions(FLL)in clinical practice.METHODS Overall,302 Lesions were studied in 136 patients who underwent MRI exams using gadoxetic acid for the assessment of FLL.Two radiologists independently reviewed the MRI exams using four stages,and categorized them on a 6-point scale,from 0(lesion not detected)to 5(definitely malignant).The stages were:stage 1-images without contrast,stage 2-addition of dynamic phases after contrast(analogous to usual extracellular contrasts),stage 3-addition of hepatobiliary phase after 10 min(HBP 10’),stage 4-hepatobiliary phase after 20 min(HBP 20’)in addition to stage 2.RESULTS The interobserver agreement was high(weighted Kappa coefficient:0.81-1)at all stages in the characterization of benign and malignant FLL.The diagnostic weighted accuracy(Az)was 0.80 in stage 1 and was increased to 0.90 in stage 2.Addition of the hepatobiliary phase increased Az to 0.98 in stage 3,which was also 0.98 in stage 4.CONCLUSION The hepatobiliary sequences improve diagnostic accuracy.With growing potential in the era of precision medicine,the improvement and dissemination of the method among medical specialties can bring benefits in the management of patients with FLL that are difficult to diagnose. | Daniel Alvarenga Fernandes Eduardo Andreazza Dal Lago Felipe Aguera Oliver Bruna Melo Coelho Loureiro Daniel Lahan Martins Thiago José Penachim Ricardo Hoelz de Oliveira Barros José de ArimatéiaBatista Araújo Filho Larissa Bastos Eloy da Costa Áurea Maria Oliveira da Silva Elaine Cristina de Ataíde Ilka de Fátima Santana Ferreira Boin Nelson Marcio Gomes Caserta | 2022 | World Journal of Hepatology2022，14，7： | 0 |
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