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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Chest compression force of trained and untrained CPR rescuers显示文摘 | GEDDES L A BOLAND M K TALEYARKHAN P R | 2007 | Cardiovasc Eng2007，7，： | 1 |
| 3 | Cell and organ printing I:Protein and cell printers显示文摘 | Cris W Wilson J R Boland T | 2003 | The Anatomical Record Part A2003，272，2： | 1 |
| 4 | Index of plant hosts of Sclerotinia sclerotirum 显示文摘 | Boland G J Hall R | 1994 | Can J Plant Pathol1994，16，： | 1 |
| 5 | Structural complementation of the catalytic domain of Pseudomonas exotoxin A显示文摘 | Boland E L Van Dyken C M Ducker R M | 2014 | J Mol Biol2014，426，3： | 1 |
| 6 | Evaluating soybean cultivars for resistance to Sclerotinia scleratiorum under field conditions 显示文摘 | Boland G J Hall R | 1987 | Plant Disease1987，71，10： | 1 |
| 7 | Index of plant hosts of Sclerotinia sclerotiorum 显示文摘 | Boland G J Hall R | 1994 | Plant Pathol1994，16，： | 1 |
| 8 | Development and evaluation of ar-pecision for arm and hand volunteer and measuring cylinder 显示文摘 | Boland R Adams R | 1996 | J Hand Ther1996，9，4： | 1 |
| 9 | A national cancer institute workshop on hereditary nonpolyposis colorectal cancer syndrome:meeting highlights and bethesda guidelines显示文摘 | RODRIGUEZ-BIGAS M A BOLAND C R HAMILTON S R | 1997 | J Natl Cancer Inst1997，89，： | 1 |
| 10 | Index of plant hosts of Sclerotinia sclerotio- rum显示文摘 | Boland G J Hall R | 1994 | Can J Plant Pathol1994，16，2： | 1 |
| 11 | COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ显示文摘 | Boland GP Butt IS Prasad R | 2004 | Br J Cancer2004，90，2： | 1 |
| 12 | Index of plant hosts of Sclerotinia sclerotiorum显示文摘 | Boland G J Hall R | 1994 | Plant Pathol1994，，16： | 1 |
| 13 | Growth room evaluation of soybean cul- tivars for resistance to Sclerotinia sclerotiorum显示文摘 | Boland G J Hall R | 1986 | Canadi- an Journal Plant Science1986，66，： | 1 |
| 14 | An index of plant hosts susceptible to Sclerotinia sclerotiorum 显示文摘 | Boland G J Hall R | 1994 | Canadian Journal of Plant Pathology1994，16，： | 1 |
| 15 | Cathepsins and osteo- sarcoma: Expression analysis identifies cathepsin K as an indi- cator of metastasis显示文摘 | Husmann K Muff R Bolander ME | 2008 | Mol Carcinog2008，47，1： | 1 |
| 16 | Role of VDR in 1α,25-dihydroxyvitamin D3-dependent non-genomic activation of MAPKs,Src and Akt in skeletal muscle cells显示文摘 | Buitrago C Pardo VG Boland R | 2013 | J Steroid Biochem Mol Biol2013，136，： | 1 |
| 17 | Participation of protein kinase C alpha in 1,25-dihydroxy-vitamin D3 regulation of chick myoblast proliferation and differentiation显示文摘 | Capiati D A Tellez-Inon M T Boland R L | 1999 | Mol Cell Endocrinol1999，153，： | 1 |
| 18 | Cultural variation ineye movements during scene perception显示文摘 | Nisbett R E Chua H F Boland J E | 2005 | Proceedings ofthe National Academy of Sciences of the United States ofAmerica2005，102，12： | 1 |
| 19 | Evaluating soybean cultivars for resist- ance to Sclerotinia sclerotiorum under field condition显示文摘 | Boland G J Hall R | 1987 | Plant Disease1987，71，： | 1 |
| 20 | Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non-small cell lung carcinomas显示文摘 | Boland J M Erdogan S Vasmatzis G Yang P Tillmans L S Johnson M R | 2009 | Hum Pathol2009，40，： | 1 |
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