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| 1 | Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner显示文摘Cold-inducible RNA-binding protein (CIRP) is a novel inflammatory mediator that stimulates the release of proinflammatory cytokines from macrophages in sepsis. Given the immune dysregulation that characterizes sepsis, the effect of CIRP on other immune cells is an area of increasing interest that has not yet been studied. In the present study, we hypothesized that extracellular CIRP promotes activation of T lymphocytes in the spleen during sepsis. We observed that mice subjected to sepsis by cecal ligation and puncture showed significantly higher expression of the early activation markers CD69 and CD25 at 20 h on CD4+ splenic T cells, and significantly higher CD69 expression on CD8+ splenic T cells compared with sham-operated controls. Furthermore, at 20 h after receiving intravenous injection of recombinant murine CIRP (rmCIRP, 5 mg/kg body weight (BW)) or PBS (vehicle), those mice receiving rmCIRP showed significantly increased expression of CD69 and CD25 on both CD4+ and CD8+ splenic T cells. This effect, however, was not seen in TLR4-deficient mice after rmCIRP injection. In addition, treatment with CIRP predisposed CD4+ T cells to a Th1 hyperinflammatory response profile, and influenced CD8+ T cells toward a cytotoxic profile. Taken together, our findings indicate that CIRP is a proinflammatory mediator that plays an important role in T-cell dysregulation during sepsis in a TLR4-dependent manner. | Alexandra C Bolognese Archna Sharma Weng-Lang Yang Jeffrey Nicastro Gene F Coppa Ping Wang | 2018 | Cellular & Molecular Immunology2018，15，1： | 4 |
| 2 | Endoscopic retrograde cholangiography for intrabiliary rupture of hydatid cyst显示文摘 | Gaspare Galati Antonio V. Sterpetti Maria Caputo Marianna Adduci Giorgio Lucandri Stefania Brozzetti Antonio Bolognese Antonino Cavallaro | 2006 | The American Journal of Surgery2006，，2： | 2 |
| 3 | The clinical burden of contrast media-induced nephropatht显示文摘 | Liistro F Falsini G Bolognese L | | 0，，10： | 1 |
| 4 | Efficacy and safety of rosuvastatin and atorvastatin in patients with hypercholesterol-emia and a high risk of coronary heart disease:a randomized,controlled trial显示文摘 | Schwarts GG Bolognese MA Tremblay BP | 2004 | Am Heart J2004，148，： | 1 |
| 5 | The Clinical burden of contrast-media-induced nephropathy显示文摘 | Liistro F Falsini G Bolognese L | 2003 | Ital Heart J2003，4，10： | 1 |
| 6 | Left ventricular remode-ling after primary coronary angioplasty patterns of left ventricular dilation and long-term prognostic implations 显示文摘 | Bolognese L Neskovic AN Parodi G | 2002 | Circulation2002，106，18： | 1 |
| 7 | A 52-week place- bo-controlled trial of evolocumab in hyperlipidemia显示文摘 | Blom DJ Hala T Bolognese M | 2014 | N Engl J Med2014，370，19： | 1 |
| 8 | Relation between ST-segment changes and myocardial perfusion evaluated by myocardial contrast echocardiography in patients with acute myocardial infarction treated with direct angioplasty显示文摘 | Giovanni M Santoro Renato Valenti Piergiovanni Buonamici Leonardo Bolognese Giampaolo Cerisano Guia Moschi Maurizio Trapani David Antoniucci Pier Filippo Fazzini | 1998 | The American Journal of Cardiology1998，，8： | 1 |
| 9 | Airway infil- tration Of CIM + CCR6 Thl7 type cells associated with chronic cigarettesmoke induced airspace enlargement 显示文摘 | I~arrison O J Foley J Bolognese B J | 2008 | Immunol Lett2008，121，1： | 1 |
| 10 | Prognostic implications of restrictive left ventricular filling in reperfused anterior acute myocardial infarction显示文摘 | Cerisano G Bolognese L Buonamic P | 2001 | J Am Coll Cardiol2001，37，： | 1 |
| 11 | Prognostic value of left ventricular mass in uncomplicated acute myocardial infarction and one vessel coronary artery disease显示文摘 | Bolognese L Dellavesa P Rossi L | | 0，，03： | 1 |
| 12 | Impact of microvascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction显示文摘 | BOLOGNESE L CARRABBA N PARODI G | 2004 | Circulation2004，109，： | 1 |
| 13 | Randomized comparison of upstream tirofiban versus downstream high bolus dose tirofiban or abciximab on tissue-level perfusion and troponin release in high-risk acute coronary syndromes treated with percutaneous coronary interventions:the EVEREST trial显示文摘 | Bolognese L Falsini G Liistro F | 2006 | J Am Coll Cardiol2006，47，3： | 1 |
| 14 | Effects of arzoxifene on bone mineral density and endometrium in postmenopausal women with normal or low bone mass 显示文摘 | Bolognese J Krege WH Utian WH | 2009 | J Clin Endocrinol Metab2009，94，7： | 1 |
| 15 | Impact of mierovascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction显示文摘 | Bolognese L Carrabba N Parodi G | 2004 | Circulation2004，109，9： | 1 |
| 16 | Prognostic value of left ventricular mass in uncomplicated acute myocardial infarction and one vessel coronary artery disease 显示文摘 | Bolognese L Dellavesa P Rossi L | 1994 | Am J Cardiol1994，73，3： | 1 |
| 17 | Modulation of angiogenesis in a model of chronic inflammation 显示文摘 | Jackson JR Bolognese B Kircher CH | 1997 | Inflamm Res1997，46，2： | 1 |
| 18 | A clinical trial comparing primary stenfing of the infarct-related artery with optimal primary angioplasty for acute myocardial infarction:Results from the Florence Randomized Elective Stenting in Acute Coronary Occlusions (FRESCO) trial 显示文摘 | Antoniucci D Santoro GM Bolognese L | 1998 | J Am Coll Cardiol1998，31，： | 1 |
| 19 | Left ventricular remodeling after coronary angioplasty : patterns of left ventricular dilation and long- term prognostic implications 显示文摘 | Bolognese L Neskovic AN Parodi G | 2002 | Circulation2002，106，18： | 1 |
| 20 | Tailored operative technique for Chiari type I malformation using intraoperative color Doppler ultrasonography 显示文摘 | Milhorat TH Bolognese PA | 2003 | Neurosurgery2003，53，4： | 1 |
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