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| 1 | Tissue expression and developmental regulation of chicken cathelicidin antimicrobial peptides显示文摘Cathelicidins are a major family of antimicrobial peptides present in vertebrate animals with potent microbicidal and immunomodulatory activities. Four cathelicidins, namely fowlicidins 1 to 3 and cathelicidin B1, have been identified in chickens. As a first step to understand their role in early innate host defense of chickens, we examined the tissue and developmental expression patterns of all four cathelicidins. Real-time PCR revealed an abundant expression of four cathelicidins throughout the gastrointestinal, respiratory, and urogenital tracts as well as in all primary and secondary immune organs of chickens. Fowlicidins 1 to 3 exhibited a similar tissue expression pattern with the highest expression in the bone marrow and lung, while cathelicidin B1 was synthesized most abundantly in the bursa of Fabricius. Additionally, a tissue-specific regulatory pattern was evident for all four cathelicidins during the first 28 days after hatching. The expression of fowlicidins 1 to 3 showed an age-dependent increase both in the cecal tonsil and lung, whereas all four cathelicidins were peaked in the bursa on day 4 after hatching, with a gradual decline by day 28. An abrupt augmentation in the expression of fowlicidins 1 to 3 was also observed in the cecum on day 28, while the highest expression of cathelicidin B1 was seen in both the lung and cecal tonsil on day 14. Collectively, the presence of cathelicidins in a broad range of tissues and their largely enhanced expression during development are suggestive of their potential important role in early host defense and disease resistance of chickens. | Mallika Achanta Lakshmi T Sunkara Gan Dai Yugendar R Bommineni Weiyu Jiang Guolong Zhang | 2012 | Journal of Animal Science and Biotechnology2012，3，2： | 3 |
| 2 | Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken显示文摘 | Xiao Y Dai H Bommineni Y R et ol | 2006 | FEBS J2006，273，12： | 1 |
| 3 | Fowlicidin-3 is an α-helical cationic host defense peptide with potent antibacterial and lipopolysaecharide-neutralizing activities 显示文摘 | Bommineni Y R Dai H Gong Y X | 2007 | FEBS J2007，274，2： | 1 |
| 4 | Butyrate enhances disease resistance of chickens by inducing antimicrobial host defense peptide gene expression显示文摘 | Sunkara LT Achanta M Schreiber NB Bommineni YR Dai G.Jiang W Lamont S Lillehoj HS Beker A Teeter RG | | 0，，11： | 1 |
| 5 | Transformation of white spruce (Picea glauca) somatic embryos by microprojectile bombardment显示文摘 | V. R. Bommineni R. N. Chibbar R. S. S. Datla E. W. T. Tsang | 1993 | Plant Cell Reports1993，，1： | 1 |
| 6 | Maturation of stamens and ovaries on cultured ear inflorescences of maize (Zea mays L.)显示文摘 | V. R. Bommineni | 1990 | Plant Cell Tissue and Organ Culture1990，，1： | 1 |
| 7 | Identification and functional characterization of three chicken cathelicidins with potent antimicrobial activity 显示文摘 | Xiao Y Cai Y Bommineni Y R | 2006 | J Biol Chem2006，281，5： | 1 |
| 8 | Regeneration of plantlets through isolated seutellum culture of durum wheat 显示文摘 | Bommineni V Janhar P | 1996 | Plant Sci1996，116，： | 1 |
| 9 | Fowlicidin-3 is an α-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities 显示文摘 | Bommineni Y R Dai H Gong Y X | 2007 | FEBS J2007，274，2： | 1 |
| 10 | A rapid method for in vitro micropropagation of apple and pear显示文摘 | BOMMINENI V R MATHEWS H SAMUEL S B | 2001 | Hortscienee2001，36，6： | 1 |
| 11 | Recovery of fertile plants from isolated,cultured maize shoot apices显示文摘 | Bommineni V R Walden D B Greyson R I | 1989 | Plant Cell Tissue and Organ Culture1989，19，3： | 1 |
| 12 | Fowlicidin-3 is a β-he- lical cationic host defense peptide with potent antibacterial and li- popolysaccharide-neutralizing activities显示文摘 | Bommineni Y R Dai H Gong Y X | 2007 | FEBS J2007，274，2： | 1 |
| 13 | Identification and functional characterization of three chicken cathelicidins with potent antimicrobial activity显示文摘 | XIAO Y CAI Y BOMMINENI Y R | | 0，，： | 1 |
| 14 | Evaluation and validation of housekeeping genes in response to ionizing radiation and chermical exposure for normalizing RNA expression in real-time PCR显示文摘 | Banda M Bommineni A Thomas R A? | 2008 | Mutation Research-Genetic Toxicology and Environmental Mutagenesis2008，649，12： | 1 |
| 15 | Thecentral kink region of fowlicidin-2, an a-helicalhost defense peptide, is critically involved inbacterial killing and endotoxin neutralization显示文摘 | Xiao YJ Herrera Al Bommineni YR | 2009 | Journal of Innate Immunity2009，1，26： | 1 |
| 16 | Fowlicidin-3 is an a -helical cationic host defensepeptide with potent antibacterial andlipopolysaccharide-neutralizing activities显示文摘 | Bommineni YR Dai HE Gong YX | 2007 | TheFEBS Journal2007，274，2： | 1 |
| 17 | Identification and functional characterization of three chicken eathelici- dins with potent antimicrobial activity 显示文摘 | Xiao Y Cai Y Bommineni Y R | 2006 | J Biol Chem2006，281，： | 1 |
| 18 | Identification and functional characterization ofthree chicken cathelicidins with potentantimicrobial activity 显示文摘 | Xiao YJ Cai YB Bommineni YR | 2006 | The Journal of BiologicalChemistry2006，281，5： | 1 |
| 19 | Identification and functional characterization of three chicken cathelicidins with potent antimicrohial activity 显示文摘 | Xiao Y Cai Y Bommineni YR | 2006 | J Biol Chem2006，281，5： | 1 |
| 20 | Evaluation and validation of housekeeping genes in response to ionizing radiation and chemical exposure for normalizing RNA expression in real -time PCR显示文摘 | Banda M Bommineni A Thomas RA | | 0，，： | 1 |
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