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| 1 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 2 | The endothelia cell protein C receptor:Its role in thrombosis显示文摘 | Navarro S Bonet E Estelles A | 2011 | Thromb Res2011，128，5： | 1 |
| 3 | High pressure die casting simulation using a lagrangian particle method显示文摘 | Kulasegaram S Bonet J Lewis J | 2003 | Communication in Numerical Methods in Engineering2003，19，9： | 1 |
| 4 | Correction and stabilization of smooth particle hydrodynamics methods with applications in metal forming simulations显示文摘 | BONET J KULASEGARAM S | 2000 | International Journal of Numerical Methods in Engineering2000，47，： | 1 |
| 5 | Variational formulation based Contaet algorithm for rigid boundaries in twodimensional SPH applications显示文摘 | Kulasegaram S Bonet J Lewis RW | 2004 | Computational Mechanics2004，33，： | 1 |
| 6 | Beta-adrenergic blocking agents in heartfailure:benefits of vasodilating and non-vasodilating agents according to patients′characteristics:a meta-analysis of clinical trails显示文摘 | Bonet S Agusti A Arnau JM | 2000 | Arch Intern Med2000，160，： | 1 |
| 7 | Functional analysisof two haplotypes of the human endothelial protein C re-ceptor gene显示文摘 | Medina P Navarro S Bonet E | 2014 | Arterioscler Thromb Vase Biol2014，34，3： | 1 |
| 8 | The formation of wrinkles in single-layer graphene sheets under nanoindentation显示文摘 | A J Gil S Adhikari F Scarpa J Bonet | 2010 | Journal of Physics: Condensed Matter2010，，14： | 1 |
| 9 | Correction and stabilization methods for smooth particle hydrodynamics method with applications to metal forming simulations 显示文摘 | Bonet J Kulasegaram S | 2000 | Compu Methods Appl Mech Engrg2000，47，： | 1 |
| 10 | A simplified approach to enhance the performance of smooth particle hydrodynamics methods 显示文摘 | BONET J KULASEGARAM S | 2002 | Applied Mathematics and Computation2002，326，2： | 1 |
| 11 | Synthesis of nanodisperse Au, Pt, Pd, Ru and Ir nanoparticles in ethylene glycol 显示文摘 | Bonet F Delmas V Grugeon S | 1999 | NanoStructured Materials1999，11，： | 1 |
| 12 | Multiresolution sampling procedure for analysis and synthesis of texture images显示文摘 | JEREMY S DE BONET | 1997 | Computer Graphics1997，31，： | 1 |
| 13 | 显示文摘 | Bonet F Delmas V Grugeon S | 1999 | NanoStructured Materials1999，11，8： | 1 |
| 14 | Variational and Momentum Preser- vation Aspects of Smooth Particle Hydrodynamic Formu-lations显示文摘 | Bonet J Lok T S L | 1999 | Computer Methods in Applied Mechanics and Engineering1999，180，1： | 1 |
| 15 | Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome(PNAS)显示文摘 | OHANNA M GIULIANO S BONET C | 2011 | Genes Dev2011，25，12： | 1 |
| 16 | Synthesis of monodisperse Au,Pt,Pd,Ru and Ir nanoaprticles in ethylene glycol显示文摘 | BONET F DELMAS V GRUGEON S | 1999 | NanoStructured Materials1999，11，8： | 1 |
| 17 | Synthesis of monodisperse Au, Pt, Pd, Ru and Ir nanoparticles in ethylene glycol 显示文摘 | Bonet F Delmas V Grugeon S | 1999 | Nanostructured Materials1999，11，： | 1 |
| 18 | Multiresolution sampling procedure for analysis and synthesis of texture images显示文摘 | J S de Bonet | 1997 | In Proc ACM Conf Comp Graphics (SIGGRAPH)1997，31，： | 1 |
| 19 | ACE inhibitors improve nephrin expression in Zueker rats with glomeruloselerosis显示文摘 | Blaneo S Bonet J L 6 pez D | 2005 | Kidney Int2005，，： | 1 |
| 20 | Prevention of peritoneal adhesion by administration of sodium carboxymethlcellulose and oral vitamin E显示文摘 | Hemadeh O Chilukuri S bonet V | 1993 | Surgery1993，114，5： | 1 |
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