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| 1 | Management of psoriasis patients with hepatitis B or hepatitis C virus infection显示文摘The systemic therapies available for the management of Psoriasis(PsO) patients who cannot be treated with more conservative options, such as topical agents and/or phototherapy, with the exception of acitretin, can worsen or reactivate a chronic infection. Therefore, before administering immunosuppressive therapies with either conventional disease-modifying drugs(c DMARDs) or biological ones(b DMARDs) it is mandatory to screen patients for some infections, including hepatitis B virus(HBV) and hepatitis C virus(HCV). In particular, the patients eligible to receive an immunosuppressive drug must be screened for the following markers: antibody to hepatitis B core, antibody to hepatitis B surface antigen(anti-HBs Ag), HBs Ag, and antibody to HCV(anti-HCV). In case HBV or HCV infection is diagnosed, a close collaboration with a consultant hepatologist is needed before and during an immunosuppressive therapy. Concerning therapy with immunosuppressive drugs in PsO patients with HBV or HCV infection, data exist mainly for cyclosporine a(Cy A) or b DMARDs(etanercept, adalimumab, infliximab, ustekinumab). The natural history of HBV and HCV infection differs significantly as well as the effect of immunosuppression on the aforementioned infectious diseases. As a rule, in the case of active HBV infection, systemic immunosuppressive antipsoriatic therapies must be deferred until the infection is controlled with an adequate antiviral treatment. Inactive carriers need to receive antiviral prophylaxis 2-4 wk before starting immunosuppressive therapy, to be continued after 6-12 mo from its suspension. Due to the risk of HBV reactivation, these patients should be monitored monthly for the first 3 mo and then every 3 mo for HBV DNA load together with transaminases levels. Concerning the patients who are occult HBV carriers, the risk of HBV reactivation is very low. Therefore, these patients generally do not need antiviral prophylaxis and the sera HBs Ag and transaminases dosing can be monitored every 3 mo. Concerning PsO patients with chronic HCV infection their management with immunosuppressive drugs is less problematic as compared to those infected by HBV.In fact, HCV reactivation is an extremely rare event after administration of drugs such as CyA or tumor necrosis factor-α inhibitors. As a rule, these patients can be monitored measuring HCV RNA load, and ALT, aspartate transaminase, gamma-glutamyl-transferase, bilirubin, alkaline phosphatase, albumin and platelet every 3-6 mo. The present article provides an updated overview based on more recently reported data on monitoring and managing PsO patients who need systemic antipsoriatic treatment and have HBV or HCV infection as comorbidity. | Claudio Bonifati Viviana Lora Dario Graceffa Lorenzo Nosotti | 2016 | World Journal of Gastroenterology2016，22，28： | 6 |
| 2 | Antioxidant activity and dietary fiber in durum wheat bran by-products显示文摘 | ESPOSITO F ARLOTTI G BONIFATI A M | 2005 | Food Research International2005，38，： | 1 |
| 3 | Comparative Analysis of Five XML Query Languages显示文摘 | A Bonifati S Ceri | 2000 | ACM SIGMOD Record2000，29，1： | 1 |
| 4 | Capillaroscopy in psoriatic and rheumatoid arthritis: a useful tool for differential diagnosis 显示文摘 | Graceffa D Amorosi B Maiani E Bonifati C Cbi menti MS Perrieone R Di Carlo A | 2013 | Arthritis2013，，95： | 1 |
| 5 | Antioxidant activity and dietary fiber in durum wheat br-an byproducts显示文摘 | Esposito F Arlottib G Bonifati A M | 2005 | Food Research International2005，38，： | 1 |
| 6 | Cytokines in psoriasis显示文摘 | Bonifati C Ameglio F | 1999 | Int J Dermatol1999，38，： | 1 |
| 7 | Antioxidant activity and dietary fibre in durum wheat bran by-products显示文摘 | FABRIZIO E GUIDO A BONIFATI A M | 2005 | Food Research International2005，38，10： | 1 |
| 8 | Correlated increases of tumour necrosis factor-alpha,interleukin6 and granulocyte monocyte-colony stimulating factor levels in suction blister fluids and sera of psoriatic patients-relationship with disease severity 显示文摘 | Bonifati C carducci M Cordiali-Fei P | 1994 | Clin Exp Dermatol1994，19，5： | 1 |
| 9 | Case-control study of multiple system atrophy显示文摘 | Vanacore N Bonifati V Fabbrini G | 2005 | Mov Disord2005，20，2： | 1 |
| 10 | Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-onset Parkinsonism显示文摘 | RIZZU P NANBAREN MJ | 2003 | Science(S0036-8075)2003，299，5604： | 1 |
| 11 | A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson’s disease risk in Taiwan显示文摘 | Alessio Fonzo Yah-Huei Wu-Chou Chin-Song Lu Marina Doeselaar Erik J. Simons Christan F. Rohé Hsiu-Chen Chang Rou-Shayn Chen Yi-Hsin Weng Nicola Vanacore Guido J. Breedveld Ben A. Oostra Vincenzo Bonifati | 2006 | Neurogenetics2006，，3： | 1 |
| 12 | Mutations in the DJ 1 gene associated with autosomal recessive early-onset parkinsonism显示文摘 | Bonifati V Rizzu P van Baren M J | 2003 | Science2003，299，5604： | 1 |
| 13 | Antioxidant activity and dietary fiber in durum wheat bran by-products 显示文摘 | Esposito F Arlotti G Bonifati A M | 2005 | Food Research International2005，38，： | 1 |
| 14 | Antioxidant activity and dietary fibre in durum wheat bran by-products显示文摘 | ESPOSITO F ARLOTTI G BONIFATI A M | 2005 | Food Research International2005，38，： | 1 |
| 15 | Serum TNF-a levers correlate with disease severity and reduced by effective therapy in plaque-type psoriasis 显示文摘 | Mussi A Bonifati C Carducci M | 1997 | J Biol Regul Homeost Agents1997，11，3： | 1 |
| 16 | Endothelin-1 levels are increased in sera and lesional skin extracts of psoriatic patients and correlate with disease severity 显示文摘 | Bonifati C Mussi A Carducci M | 1998 | Acta Derm Venereol1998，78，： | 1 |
| 17 | Antioxidant activity and dietary fibre in durum wheat bran by-products显示文摘 | Esposito F Arlotti G Bonifati A M | 2005 | Food Research International2005，38，10： | 1 |
| 18 | Antioxidant activity and dietary fiber in durum wheat bran by-products显示文摘 | Esposito F Arlotti G Bonifati A M | 2005 | Food Research International2005，38，10： | 1 |
| 19 | Serum TNF - al- pha levelsorelate with disease severity and are reduced by effective ther - apy in plaque - type psoriasis 显示文摘 | Mussi A Bonifati C Carducci M | 1997 | J Biol Regul Hemeost Agcnts1997，11，3： | 1 |
| 20 | Carotid stenosis as predictor of stroke after transient is chemic at tacks显示文摘 | Bonifati D M Lorenzi A Ermani M | 2011 | J Neural Sci2011，303，： | 1 |
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