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| 1 | Liver stiffness in the hepatitis B virus carrier:A non-invasive marker of liver disease influenced by the pattern of transaminases显示文摘AIM: To investigate the usefulness of transient elastography by Fibroscan (FS),a rapid non-invasive technique to evaluate liver fibrosis,in the management of chronic hepatitis B virus (HBV) carriers.METHODS: In 297 consecutive HBV carriers,we studied the correlation between liver stiffness (LS),stage of liver disease and other factors potentially influencing FS measurements.In 87 chronic hepatitis B (CHB) patients,we monitored the FS variations according to the spontaneous or treatment-induced variations of biochemical activity during follow-up.RESULTS: FS values were 12.3 ± 3.3 kPa in acute hepatitis,10.3 ± 8.8 kPa in chronic hepatitis,4.3 ± 1.0 kPa in inactive carriers and 4.6 ± 1.2 kPa in blood donors.We identified the cut-offs of 7.5 and 11.8 kPa for the diagnosis of fibrosis ≥ S3 and cirrhosis respectively,showing 93.9% and 86.5% sensitivity,88.5% and 96.3% specificity,76.7% and 86.7% positive predictive value (PPV),97.3% and 96.3% negative predictive value (NPV) and 90.1% and 94.2% diagnostic accuracy.At multivariate analysis in 171 untreated carriers,fibrosis stage (t = 13.187,P < 0.001),active vs inactive HBV infection (t = 6.437,P < 0.001),alanine aminotransferase (ALT) (t = 4.740,P < 0.001) and HBV-DNA levels (t = -2.046,P = 0.042) were independently associated with FS.Necroinflammation score (t = 2.158,> 10/18 vs ≤ 10/18,P = 0.035) and ALT levels (t = 3.566,P = 0.001) were independently associated with LS in 83 untreated patients without cirrhosis and long-term biochemical remission (t = 4.662,P < 0.001) in 80 treated patients.During FS monitoring (mean follow-up 19.9 ± 7.1 mo) FS values paralleled those of ALT in patients with hepatitis exacerbation (with 1.2 to 4.4-fold increases in CHB patients) and showed a progressive decrease during antiviral therapy.CONCLUSION: FS is a non-invasive tool to monitor liver disease in chronic HBV carriers,provided that the pattern of biochemical activity is taken into account.In the inactive carrier,it identifies non-HBV-related causes of liver damage and transient reactivations.In CHB patients,it may warrant a more appropriate timing of control liver biopsies. | Filippo Oliveri Barbara Coco Pietro Ciccorossi Piero Colombatto Veronica Romagnoli Beatrice Cherubini Ferruccio Bonino Maurizia Rossana Brunetto | 2008 | World Journal of Gastroenterology2008，14，40： | 43 |
| 2 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 3 | Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation: An Italian position statement显示文摘Alcoholic liver disease encompasses a broad spectrum of diseases ranging from steatosis steatohepatitis,fibrosis,and cirrhosis to hepatocellular carcinoma.Forty-four per cent of all deaths from cirrhosis are attributed to alcohol.Alcoholic liver disease is the second most common diagnosis among patients undergoing liver transplantation(LT).The vast majority of transplant programmes(85%)require 6 mo of abstinence prior to transplantation;commonly referred to as the'6-mo rule'.Both in the case of progressive end-stage liver disease(ESLD)and in the case of severe acute alcoholic hepatitis(AAH),not responding to medical therapy,there is a lack of evidence to support a 6-mo sobriety period.It is necessary to identify other risk factors that could be associated with the resumption of alcohol drinking.The'Group of Italian Regions'suggests that:in a case of ESLD with model for end-stage liver disease<19 a 6-mo abstinence period is required;in a case of ESLD,a 3-mo sober period before LT may be more ideal than a 6-mo period,in selected patients;and in a case of severe AAH,not respond-ing to medical therapies(up to 70%of patients die within 6 mo),LT is mandatory,even without achieving abstinence.The multidisciplinary transplant team must include an addiction specialist/hepato-alcohologist.Patients have to participate in self-help groups. | Gianni Testino Patrizia Burra Ferruccio Bonino Francesco Piani Alessandro Sumberaz Roberto Peressutti Andrea Giannelli Castiglione Valentino Patussi Tiziana Fanucchi Ornella Ancarani Giovanna De Cerce Anna Teresa Iannini Giovanni Greco Antonio Mosti Marilena Durante Paola Babocci Mariano Quartini Davide Mioni Sarino Aricò Aniello Baselice Silvia Leone Fabiola Lozer Emanuele Scafato Paolo Borro | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 4 | A Generic Workflow for the Data FAIRification Process显示文摘The FAIR guiding principles aim to enhance the Findability,Accessibility,Interoperability and Reusability of digital resources such as data,for both humans and machines.The process of making data FAIR(“FAIRification”)can be described in multiple steps.In this paper,we describe a generic step-by-step FAIRification workflow to be performed in a multidisciplinary team guided by FAIR data stewards.The FAIRification workflow should be applicable to any type of data and has been developed and used for“Bring Your Own Data”(BYOD)workshops,as well as for the FAIRification of e.g.,rare diseases resources.The steps are:1)identify the FAIRification objective,2)analyze data,3)analyze metadata,4)define semantic model for data(4a)and metadata(4b),5)make data(5a)and metadata(5b)linkable,6)host FAIR data,and 7)assess FAIR data.For each step we describe how the data are processed,what expertise is required,which procedures and tools can be used,and which FAIR principles they relate to. | Annika Jacobsen Rajaram Kaliyaperumal Luiz Olavo Bonino da Silva Santos Barend Mons Erik Schultes Marco Roos Mark Thompson | 2020 | Data Intelligence2020，2，1： | 5 |
| 5 | 左半结肠恶性梗阻行支架植入作为手术过渡对比急诊手术的长期肿瘤学结果:一项多中心随机对照试验(ESCO试验)显示文摘背景与目的:与急诊手术(emergency surgery,ES)相比,结肠恶性梗阻病例使用支架植入作为手术过渡(stenting asbridge-to surgery,SBTS)可能会降低术后并发症发生率和造口率,但其长期生存预后引发了人们的关注。本研究旨在评估SBTS对比ES治疗左半结肠恶性梗阻的3年总生存率(over-all survival, OS)、疾病进展时间(time to progression,TTP)及无疾病生存率(disease free survival,DFS),这些为此前已发表的一项随机对照研究的次要观察指标。方法:纳入5家欧洲医院收治的左半结肠恶性梗阻病例,按1:1比例随机分配到SBTS组和ES组。各中心病例由计算机生成随机序列并根据cT分期分层,且采用基于网络的隐藏方案。研究者与患者知晓治疗内容,本文分析的次要观察指标是OS、TTP和DFS。研究采用意向性分析。本试验注册号为NCT00591695。结果:2008年3月至2015年11月,144名患者被随机分配到SBTS组或ES组;115例患者可被纳入分析(SBTS组56例,ES组59例),余有20例因诊断为良性疾病、1例因内镜医师无法共同参与、8例退出研究而被剔除。中位随访时间为37个月(1~62个月),SBTS组与ES组在OS【HR=0.93,95%CI:0.49~1.76,P=0.822】、TTP【HR=0.81,95%CI:0.42~1.54, P=0.512】,DFS【HR=1.01, 95%CI:0.56~1.81, P=0.972】方面比较差异均无统计学意义。亚组分析显示两组在年龄、性别、美国麻醉学学会评分、体质量指数和p T分期方面比较差异均无统计学意义。SBTS组降结肠梗阻患者的TTP优于ES组【HR=0.44,95%CI:0.20~0.97,P=0.042】,但这些患者的OS【HR=0.73,95%CI:0.33~1.63,P=0.442】与DFS【HR=0.68,95%CI:0.34~1.34,P=0.261】比较差异均无统计学意义。结论:虽然次要观察指标不能提供强有力的支持依据,但这项随机对照试验表明至少在36个月的随访中两组的OS、TTP和DFS没有组间差异。 | 陈致奋 AREZZO A FORCIGNANò E BONINO M A | 2020 | 结直肠肛门外科2020，26，6： | 5 |
| 6 | The Need of Industry to Go FAIR显示文摘The industry sector is a very large producer and consumer of data,and many companies traditionally focused on production or manufacturing are now relying on the analysis of large amounts of data to develop new products and services.As many of the data sources needed are distributed and outside the company,FAIR data will have a major impact,both by reducing the existing internal data silos and by enabling the efficient integration with external(public and commercial)data.Many companies are still in the early phases of internal data”FAIRification”,providing opportunities for SMEs and academics to apply and develop their expertise on FAIR data in collaborations and public-private partnerships.For a global Internet of FAIR Data&Services to thrive,also involving industry,professional tools and services are essential.FAIR metrics and certifications on individuals,data,organizations,and software,must ensure that data producers and consumers have independent quality metrics on their data.In this opinion article we reflect on some industry specific challenges of FAIR implementation to be dealt with when choices are made regarding”Industry GOing FAIR”. | Herman van Vlijmen Albert Mons Arne Waalkens Wouter Franke Arie Baak Gerbrand Ruiter Christine Kirkpatrick Luiz Olavo Bonino da Silva Santos Bert Meerman Renger Jellema Derk Arts Martijn Kersloot Sebastiaan Knijnenburg Scott Lusher Rudi Verbeeck Jean-Marc Neefs | 2020 | Data Intelligence2020，2，1： | 4 |
| 7 | The“A”of FAIR-As Open as Possible,as Closed as Necessary显示文摘In order to provide responsible access to health data by reconciling benefits of data sharing with privacy rights and ethical and regulatory requirements,Findable,Accessible,Interoperable and Reusable(FAIR)metadata should be developed.According to the H2020 Program Guidelines on FAIR Data,data should be'as open as possible and as closed as necessary','open'in order to foster the reusability and to accelerate research,but at the same time they should be'closed'to safeguard the privacy of the subjects.Additional provisions on the protection of natural persons with regard to the processing of personal data have been endorsed by the European General Data Protection Regulation(GDPR),Reg(EU)2016/679,that came into force in May 2018.This work aims to solve accessibility problems related to the protection of personal data in the digital era and to achieve a responsible access to and responsible use of health data.We strongly suggest associating each data set with FAIR metadata describing both the type of data collected and the accessibility conditions by considering data protection obligations and ethical and regulatory requirements.Finally,an existing FAIR infrastructure component has been used as an example to explain how FAIR metadata could facilitate data sharing while ensuring protection of individuals. | Annalisa Landi Mark Thompson Viviana Giannuzzi Fedele Bonifazi Ignasi Labastida Luiz Olavo Bonino da Silva Santos Marco Roos | 2020 | Data Intelligence2020，2，1： | 4 |
| 8 | GO FAIR Brazil:A Challenge for Brazilian Data Science显示文摘The FAIR principles,an acronym for Findable,Accessible,Interoperable and Reusable,are recognised worldwide as key elements for good practice in all data management processes.To understand how the Brazilian scientific community is adhering to these principles,this article reports Brazilian adherence to the GO FAIR initiative through the creation of the GO FAIR Brazil Office and the manner in which they create their implementation networks.To contextualise this understanding,we provide a brief presentation of open data policies in Brazilian research and government,and finally,we describe a model that has been adopted for the GO FAIR Brazil implementation networks.The Brazilian Institute of Information in Science and Technology is responsible for the GO FAIR Brazil Office,which operates in all fields of knowledge and supports thematic implementation networks.Today,GO FAIR Brazil-Health is the first active implementation network in operation,which works in all health domains,serving as a model for other fields like agriculture,nuclear energy,and digital humanities,which are in the process of adherence negotiation.This report demonstrates the strong interest and effort from the Brazilian scientific communities in implementing the FAIR principles in their research data management practices. | Luana Sales Patricia Henning Viviane Veiga Maira Murrieta Costa Luis Fernando Sayao Luiz Olavo Bonino da Silva Santos Luis Ferreira Pires | 2020 | Data Intelligence2020，2，1： | 3 |
| 9 | Brain-gut-liver interactions across the spectrum of insulin resistance in metabolic fatty liver disease显示文摘Metabolic associated fatty liver disease(MAFLD),formerly named“nonalcoholic fatty liver disease”occurs in about one-third of the general population of developed countries worldwide and behaves as a major morbidity and mortality risk factor for major causes of death,such as cardio-vascular,digestive,metabolic,neoplastic and neuro-degenerative diseases.However,progression of MAFLD and its associated systemic complications occur almost invariably in patients who experience the additional burden of intrahepatic and/or systemic inflammation,which acts as disease accelerator.Our review is focused on the new knowledge about the brain-gut-liver axis in the context of metabolic dysregulations associated with fatty liver,where insulin resistance has been assumed to play an important role.Special emphasis has been given to digital imaging studies and in particular to positron emission tomography,as it represents a unique opportunity for the noninvasive in vivo study of tissue metabolism.An exhaustive revision of targeted animal models is also provided in order to clarify what the available preclinical evidence suggests for the causal interactions between fatty liver,dysregulated endogenous glucose production and insulin resistance. | Eleni Rebelos Patricia Iozzo Maria Angela Guzzardi Maurizia Rossana Brunetto Ferruccio Bonino | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 10 | Sustained Response of Hepatitis B e Antigen-Negative Patients 3 Years After Treatment with Peginterferon Alfa-2a显示文摘 | Patrick Marcellin Ferruccio Bonino George K.K. Lau Patrizia Farci Cihan Yurdaydin Teerha Piratvisuth Rui Jin Selim Gurel Zhi-Meng Lu Jian Wu Matei Popescu Stephanos Hadziyannis | 2009 | Gastroenterology2009，，7： | 2 |
| 11 | Efficacy of the over-the-scope clip (OTSC) for treatment of colorectal postsurgical leaks and fistulas显示文摘 | Alberto Arezzo Mauro Verra Rossella Reddavid Francesca Cravero Marco Augusto Bonino Mario Morino | 2012 | Surgical Endoscopy2012，，11： | 2 |
| 12 | Distributed Analytics on Sensitive Medical Data:The Personal Health Train显示文摘In recent years,as newer technologies have evolved around the healthcare ecosystem,more and more data have been generated.Advanced analytics could power the data collected from numerous sources,both from healthcare institutions,or generated by individuals themselves via apps and devices,and lead to innovations in treatment and diagnosis of diseases;improve the care given to the patient;and empower citizens to participate in the decision-making process regarding their own health and well-being.However,the sensitive nature of the health data prohibits healthcare organizations from sharing the data.The Personal Health Train(PHT)is a novel approach,aiming to establish a distributed data analytics infrastructure enabling the(re)use of distributed healthcare data,while data owners stay in control of their own data.The main principle of the PHT is that data remain in their original location,and analytical tasks visit data sources and execute the tasks.The PHT provides a distributed,flexible approach to use data in a network of participants,incorporating the FAIR principles.It facilitates the responsible use of sensitive and/or personal data by adopting international principles and regulations.This paper presents the concepts and main components of the PHT and demonstrates how it complies with FAIR principles. | Oya Beyan Ananya Choudhury Johan van Soest Oliver Kohlbacher Lukas Zimmermann Holger Stenzhorn Md.Rezaul Karim Michel Dumontier Stefan Decker Luiz Olavo Bonino da Silva Santos Andre Dekker | 2020 | Data Intelligence2020，2，1： | 1 |
| 13 | Chronic hepatitis Be antigen (HBeAg) negative, anti- HBe positive hepatitis B: an overview 显示文摘 | Bonino F Brunetto MR | 2003 | J Hepatol2003，39，1： | 1 |
| 14 | Photoactive TiO2 films on cellulose fibres:synthesis and characterization显示文摘 | UDDIN M J CESANO F BONINO F et a/ | 2007 | Joumal of Photochemistry and Photobiology A:chemistry2007，189，23： | 1 |
| 15 | A propose system for the nomenclature of hepatitis C viral genotypes显示文摘 | Simmonds P Alberti A Bonino F | 1994 | Hepatology1994，19，5： | 1 |
| 16 | Structural study of metastable tetragonal YSZ powders produced via sol-gel route 显示文摘 | VIAZZI C BONINO J P ANARAT F | 2008 | Journal of Alloys and Compounds2008，452，2： | 1 |
| 17 | Chronic kidney disease, severe arterial and arteriolar sclerosis and kidney neoplasia: on the spectrum of kidney involvement in MELAS syndrome显示文摘 | Piccoli GB Bonino LD Campisi P | 2012 | BMC Nephrol2012，13，： | 1 |
| 18 | Sustained Response of Hepatitis B e Antigen-Negative Patients 3 Years After Treatment with Peginterferon Alfa-2a显示文摘 | Patrick Marcellin Ferruccio Bonino George K.K. Lau Patrizia Farci Cihan Yurdaydin Teerha Piratvisuth Rui Jin Selim Gurel Zhi-Meng Lu Jian Wu Matei Popescu Stephanos Hadziyannis | 2009 | Gastroenterology2009，，7： | 1 |
| 19 | Photoactive TiO2 films on cellulose fibres: synthesis and characterization显示文摘 | Uddin M J Cesano F Bonino F | 2007 | Journal of Photochemistry and Photobiology A-Chemistry2007，189，23： | 1 |
| 20 | Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers 显示文摘 | Brunetto MR Oliveri F Colombatto P Moriconi F Ciccorossi P Coco B Romagnoli V Cherubini B Moscato G Maina AM Cavallone D Bonino F | 2010 | Gastroenterology2010，139，2： | 1 |
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