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| 1 | Molecular classifications of gastric cancers: Novel insights and possible future applications显示文摘Despite some notable advances in the systemic management of gastric cancer(GC), the prognosis of patients with advanced disease remains overall poor and their chance of cure is anecdotic. In a molecularly selected population, a median overall survival of 13.8 mo has been reached with the use of human epidermal growth factor 2(HER2) inhibitors in combination with chemotherapy, which has soon after become the standard of care for patients with HER2-overexpressing GC. Moreover, oncologists have recognized the clinical utility of conceiving cancers as a collection of different molecularlydriven entities rather than a single disease. Several molecular drivers have been identified as having crucial roles in other tumors and new molecular classifications have been recently proposed for gastric cancer as well. Not only these classifications allow the identification of different tumor subtypes with unique features, but also they serve as springboard for the development of different therapeutic strategies. Hopefully, the application of standard systemic chemotherapy, specifictargeted agents, immunotherapy or even surgery in specific cancer subgroups will help maximizing treatment outcomes and will avoid treating patients with minimal chance to respond, therefore diluting the average benefit. In this review, we aim at elucidating the aspects of GC molecular subtypes, and the possible future applications of such molecular analyses. | Silvio Ken Garattini Debora Basile Monica Cattaneo Valentina Fanotto Elena Ongaro Marta Bonotto Francesca V Negri Rosa Berenato Paola Ermacora Giovanni Gerardo Cardellino Mariella Giovannoni Nicoletta Pella Mario Scartozzi Lorenzo Antonuzzo Nicola Silvestris Gianpiero Fasola Giuseppe Aprile | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 5 |
| 2 | Comparative study of visual functions in premature pre-school children with and without retinopathy of prematurity显示文摘 | Bonotto LB Moreira AT | 2014 | Arq Bras Oftalmol2014，77，1： | 1 |
| 3 | Artifacts as sources for problem-posing activities显示文摘 | Bonotto C | 2013 | Educational Studies in Mathematics2013，83，1： | 1 |
| 4 | The natural radioactivity in water by gross alpha and beta measurements 显示文摘 | Bonotto D M Bueno T O Tessari B W | 2009 | Rad Meas2009，44，： | 1 |
| 5 | The natural radioactivity in water by gross alpha and beta measurements 显示文摘 | Bonotto D M Bueno T O Tessari B W | 2009 | Rad Meas2009，44，： | 1 |
| 6 | Structural features of macular eyes of preschoolers born preterm- analysis by optical coherence tomography, and indirect ophthalmoscopy显示文摘 | Bonotto LB Moreira AT Bortolotto CM | 2013 | Arq Bras Ojtalmol2013，76，2： | 1 |
| 7 | The challenge of targeted therapies for gastric cancer patients : the beginning of a long jour- ney 显示文摘 | Aprile G Giampieri R Bonotto M | 2014 | Expert Opin Investing Drugs2014，23，7： | 1 |
| 8 | LaSalle' s Theorems in Impulsive Semidynamical Systems显示文摘 | Bonotto E M | 2008 | Cadernos de Matem Atica2008，9，： | 1 |
| 9 | Limit Sets and the Poincar6-Bendixson Theorem in Impulsive Semidynamical Systems 显示文摘 | Bonotto E M Federson M | 2008 | J Differential Equations2008，244，： | 1 |
| 10 | Poisson Stability for Impulsive Semidynamical Systems 显示文摘 | Bonotto E M Federson M | 2009 | Nonlinear Analysis2009，71，： | 1 |
| 11 | Topological Conjugation and Asymptotic Stability in Impulsive Semidynamical Systems 显示文摘 | Bonotto E M Federson M | 2007 | J Math Anal App12007，326，： | 1 |
| 12 | LaSalle's Theorems in Impulsive Scmidynamical Systems 显示文摘 | Bonotto E M | 2009 | Nonlinear Analysis: Theory Methods & Applications2009，71，56： | 1 |
| 13 | Prevalence of retinopathy of prematurity in premature babies examined during the period 1992-1999,Joinville (SC):Evaluation of associated risks-screening显示文摘 | Bonotto L B Moreira A T Carvalho D S | 2007 | Arq Bras Oftalmol2007，70，1： | 1 |
| 14 | Discontinuous local semi-flows for Kurzweil equations leading to LaSalle's invariance principle for non- autonomous systems with impulses 显示文摘 | AFONSO S BONOTTO E M SCHWABIK S | 2011 | J Differential Equations2011，250，： | 1 |
| 15 | Looking for predictive markers in breast cancer显示文摘 | Bonotto M Fontanella C Puglisi F | 2015 | Lancet Oncol2015，16，1： | 1 |
| 16 | Critical Appraisal of Ramucirumab (IMC-1121B) for Cancer Treatment: From Benchside to Clinical Use显示文摘 | Giuseppe Aprile Marta Bonotto Elena Ongaro Carmelo Pozzo Francesco Giuliani | 2013 | Drugs2013，，18： | 1 |
| 17 | Radionuclides, heavy metals and fluorine incidence at Tapira phosphate rocks, Brazil and their industrial (by) products 显示文摘 | Da Conceicao F T Bonotto D M | 2006 | Environmental Pollution2006，139，2： | 1 |
| 18 | Oscillation for a second-order neutral differential equa-tion with impulses显示文摘 | BONOTTO E M GIMENES L P FEDERSOM M | | 0，，： | 1 |
| 19 | Oscillation for a second-order neutral differential equation with impulses显示文摘 | E.M. Bonotto L.P. Gimenes M. Federson | 2009 | Applied Mathematics and Computation2009，，1： | 1 |
| 20 | Determina- tion of weathering rate of the Morro do Ferro Th - REEs deposit, Brazil using U - isotope method 显示文摘 | Bonotto D M Fujimori K Moreira - Nordemann L M | 2007 | Applied Radiation and Iso- topes2007，，55： | 1 |
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