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| 1 | Statins and the risk of colorectal cancer: An updated systematic review and meta-analysis of 40 studies显示文摘AIM:To investigate the association between statin use and colorectal cancer risk,we conducted an updated meta-analysis of published studies.METHODS:We performed a comprehensive search for studies published up to July 2013.Eligible studies for this meta-analysis were either randomized controlled trials(RCTs)or observational studies(casecontrol or cohort)evaluating any exposure to statins and the risk of colorectal cancer.Two reviewers selected studies based on predefined inclusion criteria,and abstracted the data.Pooled relative risk(RR)estimates with their 95%CI were calculated using fixedand random-effects models.Then,we assessed the potential presence of publication bias and betweenstudies heterogeneity.To evaluate the results,we also performed a'leave-one-out'sensitivity analysis.RESULTS:A total of 40 studies,involving more than eight million subjects,contributed to the analysis.They were grouped on the basis of study design and,consequently,three separate meta-analyses were conducted.A similar modest reduction in the risk of colorectal cancer with statin use was observed,which was not statistically significant among RCTs(RR=0.89,95%CI:0.74-1.07;n=8),but reached statistical significance among cohort studies(RR=0.91,95%CI:0.83-1.00;n=13)and case-control studies(RR=0.92,95%CI:0.87-0.98;n=19).While we did not find significant evidence of selective outcome reporting or publication bias,substantial heterogeneity was detected,mainly among the observational studies.The sensitivity analysis confirmed the stability of our results.CONCLUSION:A modest reduction in risk of colorectal cancer among statin users cannot be disproved.Further targeted research is warranted.2014 Baishideng Publishing Group Co.,Limited.All | Theodore Lytras Georgios Nikolopoulos Stefanos Bonovas | 2014 | World Journal of Gastroenterology2014，20，7： | 7 |
| 2 | Calcium supplementation for the prevention of colorectal adenomas: a systematic review and meta-analysis of randomized controlled trials显示文摘AIM: To determine the efficacy of calcium supplementation in reducing the recurrence of colorectal adenomas.METHODS: We conducted a systematic review and meta-analysis of published studies. We searched Pub Med, Scopus, the Cochrane Library, the WHO International Clinical Trials Registry Platform, and the Clinical Trials.gov website, through December 2015. Randomized, placebo-controlled trials assessing supplemental calcium intake for the prevention of recurrence of adenomas were eligible for inclusion. Two reviewers independently selected studies based on predefined criteria, extracted data and outcomes(recurrence of colorectal adenomas, and advanced or 'high-risk' adenomas), and rated each trial's riskof-bias. Between-study heterogeneity was assessed, and pooled risk ratio(RR) estimates with their 95% confidence intervals(95%CI) were calculated using fixed- and random-effects models. To express the treatment effect in clinical terms, we calculated the number needed to treat(NNT) to prevent one adenoma recurrence. We also assessed the quality of evidence using GRADE.RESULTS: Four randomized, placebo-controlled trials met the eligibility criteria and were included. Daily doses of elemental calcium ranged from 1200 to 2000 mg, while the duration of treatment and follow-up of participants ranged from 36 to 60 mo. Synthesis of intention-to-treat data, for participants who had undergone follow-up colonoscopies, indicated a modest protective effect of calcium in prevention of adenomas(fixed-effects, RR = 0.89, 95%CI: 0.82-0.96; randomeffects, RR = 0.87, 95%CI: 0.77-0.98; high quality of evidence). The NNT was 20(95%CI: 12-61) to prevent one colorectal adenoma recurrence within a period of 3 to 5 years. On the other hand, the association between calcium treatment and advanced adenomas did not reach statistical significance(fixed-effects, RR = 0.92, 95%CI: 0.75-1.13; random-effects, RR = 0.92, 95%CI: 0.71-1.18; moderate quality of evidence). CONCLUSION: Our results suggest a modest chemopreventive effect of calcium supplements against recurrent colorectal adenomas over a period of 36 to 60 mo. Further research is warranted. | Stefanos Bonovas Gionata Fiorino Theodore Lytras Alberto Malesci Silvio Danese | 2016 | World Journal of Gastroenterology2016，22，18： | 6 |
| 3 | Editorial [ Hot Topic:Cancer Chemoprevention: Progress and Perspectives (Guest Editor: Stefanos Bonovas)]显示文摘 | Stefanos Bonovas | 2011 | Current Drug Targets2011，，13： | 2 |
| 4 | Developing the Evidence Base for Cancer Chemoprevention: Use of Meta-Analysis显示文摘 | Georgios K. Nikolopoulos Pantelis G. Bagos Stefanos Bonovas | 2011 | Current Drug Targets2011，，13： | 2 |
| 5 | Diabetes mellitus and risk of prostate cancer: A meta-analysis 显示文摘 | Bonovas S Filioussi K Tsantes A | 2004 | Diabetologia2004，47，6： | 1 |
| 6 | Does pravastatin promote cancer in elderly patients? A meta-analysis显示文摘 | Bonovas S Sitaras NM | 2007 | CMAJ2007，176，5： | 1 |
| 7 | Bradykinin postconditioning ameliorates focal cerebral ischemia in the rat显示文摘 | Danielisova V Gottlieb M Bonova P | 2014 | Neurochem Int2014，72，： | 1 |
| 8 | Does pravastatin promote cancer in elder- ly patients? A meta-analysis显示文摘 | Bonovas S Sitaras NM | 2007 | CMAJ2007，176，5： | 1 |
| 9 | Au- diting 655 fatalities with pelvic fractures by autopsy as a basis to e- valuate trauma care 显示文摘 | PAPADOPOULOS IN KANAKARIS N BONOVAS S | 2006 | J Am Coll Surg2006，203，1： | 1 |
| 10 | Does pravastatin promote cancer in elderly patients? a meta-analysis显示文摘 | Bonovas S Sitaras NM | | Canadian Medical Association Journal0，，： | 1 |
| 11 | Does pravastatin promote cancer in elderly patients? A meta-analysis 显示文摘 | Bonovas S Sitaras NM | 2007 | CMAJ2007，176，5： | 1 |
| 12 | ORAL CYCLOSPORINE BUT NOT TACROLIMUS REDUCES RENAL TRANSPLANT BLOOD FLOW显示文摘 | Brian J. Nankivell Jeremy R. Chapman George Bonovas Simon M. Gruenewald | 2004 | Transplantation2004，，9： | 1 |
| 13 | Diabetes mellitus as a risk factor for primary open-angle glaucoma: a meta-analysis 显示文摘 | BONOVAS S PEPONIS V FILIOUSSI K | 2004 | Diabet Med2004，21，6： | 1 |
| 14 | Delayed post- conditioning reduces post-isehemie glutamate level and improves protein synthesis in brain 显示文摘 | Bonova P Burda J Danielisova V | 2013 | Neureehem Int2013，62，6： | 1 |
| 15 | Statins and cancer risk: a confounded association显示文摘 | Bonovas S Sitaras NM | 2009 | Gastroenterology2009，137，2： | 1 |
| 16 | Efficacy and safety of more intensive lowering of LDL cholesterol显示文摘 | Stefanos Bonovas Georgios Nikolopoulos Nikolaos M Sitaras | 2011 | The Lancet2011，，9767： | 1 |
| 17 | Use of statins and breast cancer: a recta-analysis of seven randomized clinical tri- als and nine observational studies显示文摘 | Bonovas S Filioussi K Tsavaris N | 2005 | J Clin Oneol2005，23，34： | 1 |
| 18 | Efficacy and safety of more in- tensive lowering of LDL cholesterol 显示文摘 | Bonovas S Nikolopoulos G Sitaras NM | 2011 | Lancet2011，377，9767： | 1 |
| 19 | Do nonsteroidal anti- inflammatory drugs affect the risk of developing ovarian cancer?A meta-analysis 显示文摘 | Bonovas S Filioussi K Sitaras NM | 2005 | Br J Clin Pharmacol2005，60，2： | 1 |
| 20 | Does pravastatin promote cancer in elderly patients? A meta-analysis显示文摘 | BONOVAS S SITARAS N M | 2007 | CMAJ2007，176，： | 1 |
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