|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Differential expression of genes involved in the epigenetic regulation of cell identity in normal human mammary cell commitment and differentiation显示文摘The establishment and maintenance of mammary epithelial cell identity depends on the activity of a group of proteins, collectively called maintenance proteins, that act as epigenetic regulators of gene transcription through DNA methylation, histone modification, and chromatin remodeling. Increasing evidence indicates that dysregulation of these crucial proteins may disrupt epithelial cell integrity and trigger breast tumor initiation. Therefore, we explored in silico the expression pattern of a panel of 369 genes known to be involved in the establishment and maintenance of epithelial cell identity and mammary gland remodeling in cell subpopulations isolated from normal human mammary tissue and selectively enriched in their content of bipotent progenitors, committed luminal progenitors, and differentiated myoepithelial or differentiated luminal cells. The results indicated that, compared to bipotent cells, differentiated myoepithelial and luminal subpopulations were both characterized by the differential expression of 4 genes involved in cell identity maintenance: CBX6 and PCGF2, encoding proteins belonging to the Polycomb group, and SMARCD3 and SMARCE1, encoding proteins belonging to the Trithorax group. In addition to these common genes, the myoepithelial phenotype was associated with the differential expression of HDAC1, which encodes histone deacetylase 1, whereas the luminal phenotype was associated with the differential expression of SMARCA4 and HAT1, which encode a Trithorax protein and histone acetylase 1, respectively. The luminal compartment was further characterized by the overexpression of ALDH1A3 and GATA3, and the down-regulation of NOTCH4 and CCNB1, with the latter suggesting a block in cell cycle progression at the G2 phase. In contrast, myoepithelial differentiation was associated with the overexpression of MYC and the down-regulation of CCNE1, with the latter suggesting a block in cell cycle progression at the G1 phase. | Danila Coradini Patrizia Boracchi Saro Oriana Elia Biganzoli Federico Ambrogi | 2014 | Chinese Journal of Cancer2014，33，10： | 2 |
| 2 | Serum hu- man epididymis protein 4 vs carbohydrate antigen 125 for ovarian cancer diagnosis:a systematic review显示文摘 | Boracchi P Biganzoli EM Panteghini M | 2013 | J Clin Pathol2013，66，4： | 1 |
| 3 | Relationship between nutritional status and tumour growth in humans 显示文摘 | Bozzetti F Boracchi P Costa A | 1995 | Tumori1995，81，： | 1 |
| 4 | Modeling the Performance of Image Restoration from Motion Blur 显示文摘 | Boracchi G Foi A | 2012 | leee Transactions on Image Processing2012，21，8： | 1 |
| 5 | Exercise oscillatory breathing arid NT-proBNP levels in stable heart failure provide the strongest prediction of cardiac outcome when combining biomarkers with cardiopulmonary exercise testing显示文摘 | Guazzi M Boracchi P Labate V | 2012 | J Card Fail2012，18，4： | 1 |
| 6 | Ecotoxicological soil evaluation by FETAX显示文摘 | Prati M Biganzoli E Boracchi P | 2000 | Chemosphere2000，41，10： | 1 |
| 7 | Behaviour of metastasis in relation to vascular index in patients with node-positive breast cancer treated with adjuvant tamoxifen 显示文摘 | Gasparini G Fanelli M Boracchi P | 2000 | Clin Exp Metastasis2000，18，1： | 1 |
| 8 | 67-KdA laminin-receptor expression adds prognostic information to intra-tumoral microvessel density in node-negative breast cancer显示文摘 | Gasparini G barbareschi M Boracchi P | 1995 | Int J Cancer1995，60，： | 1 |
| 9 | Adjuvant chemotherapy with vincristine,cyclophosphamide,and doxorubicin after radiotherapy in local-regional nasopharyngeal cancer:results of a 4-year multicenter randomized study显示文摘 | Rossi A Molinari R Boracchi P | 1988 | J Clin Oncol1988，6，9： | 1 |
| 10 | Modeling the performance of imagerestoration from motion blur显示文摘 | Boracchi G Foi A | 2012 | IEEE Transactions onImage Processing2012，21，8： | 1 |
| 11 | Adjuvant chemotherapy with vincristine, cyclophosphamide, and doxorubicin after radiotherapy in local-regional nasopharyngeal cancer: results of a 4-year muhicenter randomized study 显示文摘 | Rossi A Molinari R Boracchi P | 1988 | J Clin Oncol1988，6，9： | 1 |
| 12 | Exercise oscillatory breathing and NT- proBNP levels in stable heart failure provide the strongest prediction of cardiac outcome when combining biomarkers with cardiopulmonary exercise testing显示文摘 | Guazzi M Boracchi P Labate V | 2012 | J Card Fail2012，18，4： | 1 |
| 13 | Inside ST-elevation myocardial infarction by monitoring concentrations of cardiovascular risk biomarkers in blood显示文摘 | Simona Ferraro Ilaria Ardoino Patrizia Boracchi Matteo Santagostino Laura Ciardi Giuseppina Antonini Federica Braga Elia Biganzoli Mauro Panteghini Angelo S. Bongo | 2012 | Clinica Chimica Acta . 2012 (9-10)2012，，： | 1 |
| 14 | New insights in the pathophysiology of acute myocardial infarction detectable by a contemporary troponin assay显示文摘 | Simona Ferraro Elia Biganzoli Giuseppe Marano Matteo Santagostino Patrizia Boracchi Mauro Panteghini Angelo S. Bongo | 2013 | Clinical Biochemistry2013，，： | 1 |
| 15 | Multiple correspondence analysis in S -plus 显示文摘 | Ambrogi F Biganzoli E Boracchi P | 2005 | Computer Methods and Programs in Biomedicine2005，79，： | 1 |
| 16 | Recurrence and mortality according to estrogen receptor status for breast cancer patients undergoing conservative surgery:ipsilateral breast tumour recurrence dynamics provides clues for tumour biology within the residual breast显示文摘 | Demicheli R Ardoino I Boracchi P | | 0，，： | 1 |
| 17 | Adjuvant chemotherapy with vincristine,cyclophosphamide,and doxorubicin after radiotherapy in localregional nasopharyngeal cancer:results of a 4-year multicenter randomized study显示文摘 | Rossi A Molinari R Boracchi P | 1988 | Clin Oncol1988，6，： | 1 |
| 18 | Naiffold capil-lar- oscopy in systemic sclerosis: data from the EULAR scleroder- ma trials and research (EUSTAR) database显示文摘 | Ingegnoli F Ardoino I Boracchi P | 2013 | Microvase Res2013，89，： | 1 |
| 19 | Adjuvant chemotherapy with vincristine, cyclophosphamide, and doxorubicin after radiotherapy in local-regional nasopharyngeal cancer: results of a 4- year multicenter randomized study 显示文摘 | Rossi A Molinari R Boracchi P | 1988 | J Clin Oncol1988，6，9： | 1 |
| 20 | Ultra-sensitive troponin I levels to exclude acute myocardial infarction from myocardial injury显示文摘 | Ferraro S Boracchi P Santagostino M | 2011 | Clin Chem Lab Med2011，50，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员