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| 1 | 豚鼠外源性血管内皮细胞生长因子增强内耳屏障转运作用的磁共振成像研究显示文摘目的观察血管内皮细胞生长因子(vascularendothelialgrowthfactor, VEGF)能否改变血迷路屏障和血外淋巴屏障的物质转运作用。方法11只300 ~900g雌雄兼并的杂色豚鼠在甲苯噻嗪(16mg/kg)和氯氨酮(60mg/kg)基础麻醉下接受手术,通过圆窗膜(明胶海绵吸附)将VEGF(6耳)或磷酸盐缓冲液(PBS, 5耳)投放至内耳。用T1对比剂二乙烯三胺五乙酸双甲酰胺钆(gadolinium diethylenetriamine pentaacetate bismethylamide, Gd DTPA BMA)作为内耳屏障转运示踪剂,用4 7T场强, 40cm孔径的BrukerBiospecAvance47 /40试验磁共振系统进行豚鼠耳蜗二维磁共振成像观测,用Paravision软件进行图像密度分析,用AdobePhotoshop6 0软件进行图像呈示。结果圆窗膜投放PBS未影响血外淋巴屏障渗透性变化。圆窗膜投放VEGF可显著增强处理侧血外淋巴屏障渗透性,VEGF处理的耳蜗鼓阶内Gd DTPA BMA转运显著增加(P<0 01 ), VEGF处理的耳蜗前庭阶内Gd DTPA BMA转运也显著增加(P<0 01)。VEGF处理的耳蜗中阶内Gd DTPA BMA转运无明显增加(P>0 05)。结论VEGF显著增强血外淋巴屏障的物质转运作用并可能有利于内耳在各种有害环境下的代偿及修复。 | 邹静 Pyykko Ilmari Bjelke Borje Counter S Allen | 2005 | 中华耳鼻咽喉头颈外科杂志2005，40，4： | 3 |
| 2 | Salient object detection= a sur- vey显示文摘 | Borj A Oheng M Jiang H | | Eprint Arxiv0，2014，： | 1 |
| 3 | Selective reduction of steroid 3- and 17-ketones using LiA1H4 activated template polymers 显示文摘 | Bystrom S E Borje A Akemark B | 1993 | J Am Chem Soc1993，115，5： | 1 |
| 4 | Podophyllotoxin derivatives:drug discovery and development显示文摘 | Lars Bohlin Borje Rosén | 1996 | Drug Discovery Today1996，1，8： | 1 |
| 5 | Transportation Infrastructure for the Malar Region显示文摘 | Borje Johansson Charlie Karlsson | 1994 | Region al Studies1994，，02： | 1 |
| 6 | Agglomeration and NetworKs in Spatial Economies显示文摘 | Borje Johansson John M Quigley | | 0，，86： | 1 |
| 7 | The thorough QT/QTc study 4 years after the imple- mentation of the ICH El4 guidance显示文摘 | BORJE D | 2010 | Br J Pharmacol2010，159，1： | 1 |
| 8 | Direct drug determination by seelective sample enrichment on an imprinted polymer显示文摘 | BORJE SELLERGREN | 1994 | Anal Chem1994，66，： | 1 |
| 9 | Podophyllotoxin derivatives:drug discovery and development显示文摘 | Lars Bohlin Borje Rosen | 1996 | Drug Discovery Today1996，1，8： | 1 |
| 10 | A sequential two-step process moderately and extremely thermophilic cultures for biooxidation of refractory gold concentrates显示文摘 | Lindstrom E Borje Ake Sandatrom Jan-Eric Sundkvist | 2003 | hydrometallurgy2003，71，： | 1 |
| 11 | Restricting Dislocation Movement in Transition Metal Carbides by Phase Stability Tuning显示文摘 | ULF Jansson BORJE Johansson | 2001 | Science2001，293，： | 1 |
| 12 | The relationship of crowding and aggressive behaviour on a physiciatric intensive care unit显示文摘 | ]Palmstierna Tom Huitfeldt Bernard Wistedt Borje | 1991 | Hospital and Community Psychiatry1991，42，： | 1 |
| 13 | Diagnostic and prognostic molecular markers for renal cell carcinoma:a critical appraisal of the current state of research and clinical applicability显示文摘 | Christian E Kerstin J Borje L | | 0，，： | 1 |
| 14 | Noncovalent molecular imprinting: Antibody-like molecular recognition in polymeric network materials 显示文摘 | Borjes S | 1997 | Trends in Analytical Chemistry1997，16，： | 1 |
| 15 | Migration ofthe Actinides Thorium,Protactinium,Uranium,Neptunium,Plutonium and Americium in Clay显示文摘 | Borje T | 1986 | Radiochim Acta1986，39，： | 1 |
| 16 | The Evolution of the Character and Practice of Distance Education 显示文摘 | Borje Holmberg | 1995 | Open Learning1995，10，2： | 1 |
| 17 | Selective reduction of steroid 3-and 17-ketones using LiAlH4 activated template polymers显示文摘 | Bystrom S E Borje A Akemark B | 1993 | J Am Chem Soc1993，115，5： | 1 |
| 18 | The influence of nail ductility on the load capacity of a glulam truss structure显示文摘 | Stehn L Borjes K | 2004 | Eng Struct2004，26，： | 1 |
| 19 | High yield preparation of 4'-(bromophenyl)-2,2':6,2'-terpyridine by a condensation reaction 显示文摘 | Peter Korall Anna Borje Per-Ola Norrby | 1997 | Acta Chemica Scandinavica1997，51，： | 1 |
| 20 | Migration of the Actinides Thorium,Protactinium,Uranium,Neptunium,Plutonium and Americium in Clay显示文摘 | Borje T | 1986 | Radiochim Acta1986，39，： | 1 |
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