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| 1 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 2 | Th2 cells are re- quired for the Schistosoma mansoni egg induced granulomatous re- sponses显示文摘 | Kaplan M H Whitefield J R Boros D L | 1998 | J Immunol1998，160，4： | 1 |
| 3 | Improving software reliability forecasting 显示文摘 | Butschy B Albeanu G Boros D N | 1997 | Microelectronies and Reliability1997，37，6： | 1 |
| 4 | Solid oxide derived from waste shells of Turbonilla striatula as a renewable catalyst for biodiesel production 显示文摘 | BORO J THAKUR A J DEKA D | 2011 | Fuel Processing Technology2011，92，10： | 1 |
| 5 | Solid oxide derived from wasteshells of Turbonilla striatula as a renewable catalyst for biodie-sel production显示文摘 | Boro J Thakur A J Deka D | 2011 | Fuel Processing Technology2011，92，10： | 1 |
| 6 | Experimental correlation of steel corrosion in pipe flow with jet impingenent and rotating cylinder lab tests显示文摘 | Efird K D Wright E J Boros J A | 1993 | Corrosion1993，，81： | 1 |
| 7 | Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response显示文摘 | Kaplan M H Whitfied J R Boros D L | 1998 | J Immunol1998，160，4： | 1 |
| 8 | Nanostruetured cerium oxide: preparation and properties of weakly-agglomerated powders 显示文摘 | Boro D Stephen P | 1999 | Janrnal of the European Ceramic Society1999，19，： | 1 |
| 9 | Disubstituted dialkoxysilane precursors in binary and ternary sol-gel systems for lipase immobilization 显示文摘 | Weiser D Boros Z Poppe L | 2012 | Process Biochemistry2012，47，： | 1 |
| 10 | Flow cytometry-based method to analyze the change in Tan phosphorylation in a hGSK-3beta and hTau over-expressing EcR-293 cell line 显示文摘 | Kurko D Boros A Dezso P | 2006 | Neurochem Int2006，48，5： | 1 |
| 11 | Experimental correlation of steel corrosion in pipe flow with )et impingement and rotating cylinder lab tests显示文摘 | EFIRD K D WRIGHT E J BOROS J A | 1993 | Corrosion1993，49，12： | 1 |
| 12 | Changes in the expression of PACAP-like compounds during the embryonic development of the earthworm Eisenia fetida 显示文摘 | BOROS A REGLODI D HERBERT Z | 2008 | Journal of Molecular Neuroscience2008，36，123： | 1 |
| 13 | Immunopathology of Schistosoma mansoni infection显示文摘 | Boros D L | 1989 | Clin Microbiol Rev1989，2，3： | 1 |
| 14 | Counterimmunoelectrophoresis in duck plague virus antigen and antibody detection显示文摘 | Sarma D K Boro B R | 1989 | Indian J Anim Sci1989，59，3： | 1 |
| 15 | Immunopathology of Schistosoma mansoni infection 显示文摘 | Boros D L | 1989 | Clin Microbiol Rev1989，2，3： | 1 |
| 16 | Chromosome location of genes controlling the content of dietary fibre and arabinxylans in rye显示文摘 | Boros D Lukaszewski A J Aniol A | 2002 | Euphytica2002，128，： | 1 |
| 17 | Solid oxide derived from waste shells of Turbonilla striatula as a renewable catalyst for biodiesel production显示文摘 | Boro J Thakur A J Deka D | 2011 | Fuel Processing Techn2011，92，10： | 1 |
| 18 | Site of exoenzyme action in gastrointestinal tract of broiler chicks 显示文摘 | Boros D R R Marquardt W Guenter | 1998 | Canada Journal of Animal Science1998，78，： | 1 |
| 19 | Low-temperature behavior of biodiesel solid liquid phase diagrams of binary mixtures composed of fatty acid methyl esters显示文摘 | Costa M C Boros L A D Coutinho J A P | 2011 | Energy & Fuels2011，25，7： | 1 |
| 20 | Chromosome location of genes controlling the content of dietary fibre and arabinxylans in rye 显示文摘 | Boros D Lukaszewski A J Aniol A Ochodzki P | 2002 | Euphytica2002，128，： | 1 |
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