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| 1 | Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma:An intricate pathway显示文摘The histo-pathologic and molecular mechanisms leading to initiation and progression of hepatocellular carcinoma(HCC)are still ill-defined;however,there is increasing evidence that the gradual accumulation of mutations,genetic and epigenetic changes which occur in preneoplastic hepatocytes results in the development of dysplastic foci,nodules,and finally,overt HCC.As well as many other neoplasias,liver cancer is considered an'inflammatory cancer',arising from a context of inflammation,and characterized by inflammation-related mechanisms that favor tumor cell survival,proliferation,and invasion.Molecular mechanisms that link inflammation and neoplasia have been widely investigated,and it has been well established that inflammatory cells recruited at these sites with ongoing inflammatory activity release chemokines that enhance the production of reactive oxygen species.The latter,in turn,probably have a major pathogenic role in the continuum starting from hepatitis followed by chronic inflammation,and ultimately leading to cancer.The relationship amongst chronic liver injury,free radical production,and development of HCC is explored in the present review,particularly in the light of the complex network that involves oxidative DNA damage,cytokine synthesis,telomere dysfunction,and microRNA regulation. | Romilda Cardin Marika Piciocchi Marina Bortolami Andromachi Kotsafti Luisa Barzon Enrico Lavezzo Alessandro Sinigaglia Kryssia Isabel Rodriguez-Castro Massimo Rugge Fabio Farinati | 2014 | World Journal of Gastroenterology2014，20，12： | 14 |
| 2 | Oxidative damage,pro-inflammatory cytokines,TGF-αand c-myc in chronic HCV-related hepatitis and cirrhosis显示文摘AIM: To assess whether a correlation exists between oxidative DNA damage occurring in chronic HCV-related hepatitis and expression levels of pro-inflammatory cytokines, TGF-αand c-myc. METHODS: The series included 37 patients with chronic active HCV-related hepatitis and 11 with HCV-related compensated cirrhosis. Eight-hydroxydeoxyguanosine in liver biopsies was quantified using an electrochemical detector. The mRNA expression of TIMF-α, IL-1β, TGF-αand c-myc in liver specimens was detected by semi-quantitative comparative RT-PCR. RESULTS: TNF-αlevels were significantly higher in hepatitis patients than in cirrhosis patients (P=0.05). IL-1βwas higher in cirrhosis patients (P=0.05). A significant correlation was found between TNF-αand staging (P=0.05) and between IL-1βlevels and grading (P=0.04). c-myc showed a significantly higher expression in cirrhosis patients (P=0.001). Eight-hydroxydeoxyguanosine levels were significantly higher in cirrhosis patients (P=0.05) and in HCV genotype 1 (P=0.03). Considering all patients, 8-hydroxydeoxyguanosine levels were found to be correlated with genotype (P=0.04) and grading (P=0.007). Also multiple logistic regression analysis demonstrated a significant correlation among the number of DNA adducts, TNF-αexpression and HCV genotype (P=0.02). CONCLUSION: In chronic HCV-related liver damage, oxidative DNA damage correlates with HCV genotype, grading and TNF-αlevels. As HCV-related liver damage progresses, TNF-αlevels drop while IL-1βand c-myc levels increase, which may be relevant to liver carcinogenesis. | Fabio Farinati Romilda Cardin Marina Bortolami Maria Guido Massimo Rugge | 2006 | World Journal of Gastroenterology2006，12，13： | 5 |
| 3 | Transcriptional downregulation of tight junction protein ZO-1 in active coeliac disease is reversed after a gluten-free diet显示文摘 | Pizzuti D Bortolami M Mazzon E | 2004 | Dig Liver Dis2004，36，： | 1 |
| 4 | Transcriptional downregulation of tight junction protein ZO-1 in active coeliac disease is reversed after a gluten-free diet显示文摘 | Pizzuti D Bortolami M Mazzon E | 2004 | Dig Liver Dis2004，36，5： | 1 |
| 5 | Estrogens receptors and oxidative damage in the liver 显示文摘 | Fabio F Cardina R Bortolami M | 2002 | Mol Cell Endocrinol2002，193，12： | 1 |
| 6 | Fas/FasL system,IL-1beta expression and apoptosis in chronic HBV and HCVliver disease显示文摘 | Bortolami M Kotsafti A Cardin R | 2008 | J Viral Hepat2008，15，7： | 1 |
| 7 | Mncosal immune en- vironment in colonic carcinogenesis: CD80 expression is associated to oxidative DNA damage and TLR4-NF K B signalling显示文摘 | SCARPA M CABDIN B BORTOLAMI M | 2013 | Eur J Caneer2013，49，1： | 1 |
| 8 | Transcriptional downregulation of tight junction protein ZO-1 in active celiac disease is reversed after a gluten-free diet显示文摘 | Pizzuti D Bortolami M Mazzon E | 2004 | Dig Liver Dis2004，36，5： | 1 |
| 9 | TGF-betal and IGF-1 and anastomotie recurrence of Crohn's disease after ileo-colonic resection 显示文摘 | Scarpa M Bortolami M Morgan SL | 2008 | J Gastrointest Surg2008，12，11： | 1 |
| 10 | Estrogens receptors and oxidative damage in the liver显示文摘 | Cardina R Bortolami M | 2002 | Molecular and Cellular Endocrinology2002，193，： | 1 |
| 11 | Transcriptional down regulation of tight junction protein ZO - 1 in active coeliac disease is reversed after a gluten - free diet 显示文摘 | PIZZUTI D BORTOLAMI M MAZZON E | 2004 | Dig Liver Dis2004，36，5： | 1 |
| 12 | Fas / FasL system,IL-lbeta expression and apoptosis in chronic HBV and HCV liver disease显示文摘 | Bortolami M Kotsafti A Cardin R | 2008 | J Viral Hepat2008，15，7： | 1 |
| 13 | Estrogens receptors and oxidative damage in the liver显示文摘 | Farinati F Cardin R Bortolami M | 2002 | Mol Cell Endoerinol2002，193，12： | 1 |
| 14 | Estrogens receptors and oxidative damage in the liver显示文摘 | Farinati F Cardin R Bortolami M | 2002 | Mol Cell Endocrinol2002，193，12： | 1 |
| 15 | Recent progress in target therapy in colorectal cancer 显示文摘 | Pasetto LM Bortolami A Falci C | 2006 | Anticancer Res2006，26，5： | 1 |
| 16 | Transcriptional downregulationof tight Junction protein ZO - 1 in active celiac disease is reversed aftera gluten - free diet 显示文摘 | Pizzuti D Bortolami M Mazzon E | 2004 | Dig liver Dis2004，36，5： | 1 |
| 17 | Fas/ FasL system,IL-1beta expression and apoptosis in chronic HBV and HCV liver disease显示文摘 | Bortolami M Kotsafti A Cardin R | | 0，，07： | 1 |
| 18 | Mucosal immune environment in colon- ic carcinogenesis : CD80 expression is associated to oxida- tive DNA damage and TLR4-NFkB signaling显示文摘 | SCARPA M CARDIN R BORTOLAMI M KOTSAFTI A5SCARPA MC POZZA A | 2013 | Eur J 0mcer2013，，： | 1 |
| 19 | Cytokine, infiltrating macrophage and T cell - mediated response to development of primary and secondary human liver cancer 显示文摘 | Bortolami M Venturi C Giacomelli L | 2002 | Dig Liver Dis2002，34，11： | 1 |
| 20 | Control and flight performance of tethered satellite small expendable deployment system-Ⅱ 显示文摘 | Lorenzini E C Bortolami S B | 1996 | Journal of Guidance Control and Dynamics1996，19，5： | 1 |
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