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| 1 | Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors显示文摘 | Giovanna Fattovich Flavia Bortolotti Francesco Donato | 2007 | Journal of Hepatology2007，，2： | 8 |
| 2 | New tools for optimizing fluid resuscitation in acute pancreatitis显示文摘Acute pancreatitis(AP)is a frequent disease with degrees of increasing severity responsible for high morbidity.Despite continuous improvement in care,mortality remains significant.Because hypovolemia,together with microcirculatory dysfunction lead to poor outcome,fluid therapy remains a cornerstone of the supportive treatment.However,poor clinical evidence actually support the aggressive fluid therapy recommended in recent guidelines since available data are controversial.Fluid management remains unclear and leads to current heterogeneous practice.Different strategies may help to improve fluid resuscitation in AP.On one hand,integration of fluid therapy in a global hemodynamic resuscitation has been demonstrated to improve outcomein surgical or septic patients.Tailored fluid administration after early identification of patients with high-risk of poor outcome presenting inadequate tissue oxygenation is a major part of this strategy.On the other hand,new decision parameters have been developed recently to improve safety and efficiency of fluid therapy in critically ill patients.In this review,we propose a personalized strategy integrating these new concepts in the early fluid management of AP.This new approach paves the way to a wide range of clinical studies in the field of AP. | Perrine Bortolotti Fabienne Saulnier Delphine Colling Alban Redheuil Sebastien Preau | 2014 | World Journal of Gastroenterology2014，20，43： | 5 |
| 3 | Gastric electrical stimulation for gastroparesis:A goal greatly pursued,but not yet attained显示文摘The lack of an effective medical treatment for gastroparesis has pushed the research of new techniques of gastric electrical stimulation (GES) for nearly half a century of experimentation with a large variety of electrical stimuli delivered to the gastric wall of animals and patients with gastroparesis. Three principal methods are currently available: gastric low-frequency/high-energy GES with long pulse stimulation, high-frequency/low-energy GES with short pulse stimulation and neural sequential GES. The first method aims to reset a regular slow wave rhythm, but has variable effects on contractions and requires devices with large and heavy batteries unsuitable for implantation. High-frequency/low-energy GES, although inadequate to restore a normal gastric electro-mechanical activity, improves dyspeptic symptoms, such as nausea and vomiting, giving patients a better quality of life together with a more satisfactory nutritional status and is suitable for implantation. Unfortunately, the numerous clinical studies using this type of GES, with the exception of two, were not controlled and there is a need for definitive verification of the effectiveness of this technique to justify the cost and the risks of this procedure. The last method, which is neural sequential GES, consists of a microprocessor-controlled sequential activation of a series of annular electrodes along the distal two thirds of the stomach and is able to induce propagated contractions causing forceful emptying of the gastric content. The latter method is the most promising, but has been used only in animals and needs to be tested in patients with gastroparesis before it is regarded as a solution for this disease. | Mauro Bortolotti | 2011 | World Journal of Gastroenterology2011，17，3： | 4 |
| 4 | Effect of omeprazole on symptoms and ultrastructural esophageal damage in acid bile reflux显示文摘AIM: To value whether omeprazole could induce the healing of DIS and regression of symptoms in patients with DGER.METHODS: We enrolled 15 symptomatic patients with a pathological esophageal 24-h pH-metry and bilimetry.Patients underwent endoscopy and biopsies were taken from the distal esophagus. Specimens were analyzed at histology and transmission electron microscopy (TEM).Patients were treated with omeprazole 40 mg/d for 3 mo and then endoscopy with biopsies was repeated. Patients with persistent heartburn and/or with an incomplete recovery of DIS were treated for 3 more months and endoscopy with biopsies was performed.RESULTS: Nine patients had a non-erosive reflux disease at endoscopy (NERD) while 6 had erosive esophagitis (ERD). At histology, of the 6 patients with erosive esophagus,5 had mild esophagitis and 1 moderate esophagitis. No patients with NERD showed histological signs of esophagitis.After 3 mo of therapy, 13/15 patients (86.7%, P<0.01)showed a complete recovery of DIS and disappearance of heartburn. Of the 2 patients treated for 3 more months,complete recovery of DIS and heartburn were achieved in one.CONCLUSION: Three or 6 mo of omeprazole therapy led to a complete regression of the ultrastructural esophageal damage in 86.7% and in 93% of patients with DGER, NERD and ERD respectively. The ultrastructural recovery of the epithelium was accompanied by regression of heartburn in all cases. | Carlo Calabrese Anna Fabbri Mauro Bortolotti Giovanna Cenacchi Scialpi Carlo Desiree Zahlane Mario Miglioli Giulio Di Febo | 2005 | World Journal of Gastroenterology2005，11，12： | 3 |
| 5 | Impact of HLA-G analysis in prevention, diagnosis and treatment of pathological conditions显示文摘Human leukocyte antigen-G(HLA-G) is a non-classical HLA class Ⅰ molecule that differs from classical HLA class Ⅰ molecules by low polymorphism and tissue distribution. HLA-G is a tolerogenic molecule with an immune-modulatory and anti-inflammatory function on both innate and adaptative immunity. This peculiar characteristic of HLA-G has led to investigations of its role in pathological conditions in order to define possible uses in diagnosis, prevention and treatment. In recent years, HLA-G has been shown to have an important implication in different inflammatory and autoimmune diseases, pregnancy complications, tumor development and aggressiveness, and susceptibility to viral infections. In fact, HLA-G molecules have been reported to alternate at both genetic and protein level in different disease situations, supporting its crucial role in pathological conditions. Specific pathologies show altered levels of soluble(s)HLA-G and different HLA-G gene polymorphisms seem to correlate with disease. This review aims to update scientific knowledge on the contribution of HLA-G in managing pathological conditions. | Daria Bortolotti Valentina Gentili Antonella Rotola Enzo Cassai Roberta Rizzo Dario Di Luca | 2014 | World Journal of Methodology2014，4，1： | 3 |
| 6 | High sustained virologic response rates in children with chronic hepatitis C receiving peginterferon alfa-2b plus ribavirin显示文摘 | Stefan Wirth Carmen Ribes-Koninckx Maria Angeles Calzado Flavia Bortolotti Lucia Zancan Paloma Jara Mark Shelton Nanda Kerkar Marcela Galoppo Alejandra Pedreira Norberto Rodriguez-Baez Mirta Ciocca Alain Lachaux Florence Lacaille Thomas Lang Ulrike Kullme | 2010 | Journal of Hepatology2010，，4： | 2 |
| 7 | Magnetic challenge against gastroesophageal reflux显示文摘Almost 15 years have passed since the first paper on the possibility of using magnets to prevent gastro-esophageal reflux(GER)was published and so it is time to assess the results obtained with the first magnetic device available on the market,the Linx magnetic sphincter augmentation(MSA)and to consider what other options are forthcoming.MSA demonstrated an anti-reflux activity similar to that of Nissen fundoplication,considered the“gold standard”surgical treatment for GER disease,and caused less gas-bloating and a better ability to allow vomiting and belching.However,unlike Nissen fundoplication,this magnetic device is burdened by complications,which are roughly similar to those of the non-magnetic anti-reflux Angelchik prosthesis,that,after considerable use in the eighties,was shelved due to these complications.It is interesting to note that some of these complications show the same pathophysiological mechanism in both devices.The upcoming new magnetic devices should avoid these complications,as their anti-reflux magnetic mechanism is completely different.The experiments in animals regarding these new magnetic appliances were examined,remarking their advantages and drawbacks,but the way to apply them in surgical practice is long and difficult,although worthy,as they represent the future of magnetic surgery. | Mauro Bortolotti | 2021 | World Journal of Gastroenterology2021，27，48： | 2 |
| 8 | 慢性乙型肝炎患儿e抗原清除后调查:一项29年的纵向研究显示文摘Chronic hepatitis B is usually a benign disease in Caucasian children;however,the long-term prognosis remains unsettled.This report describes the results of a 29-year longitudinal study including 99 white children with chronic hepatitis B,mainly acquired horizontally:91 were hepatitis B e antigen(HBeAg)-positive(4 had cirrhosis),and 8 were HBeAg negative at presentation.Of the 91 HBeAg-positive children,89 underwent HBeAg seroconversion after a mean period of 5.2 ±4.0 years and were included in the study.Of the 85 children without cirrhosis,one had HBeAg-negative hepatitis and the other 84 became inactive carriers.During a mean follow-up of 14.5 ±6.1 years after HBeAg seroclearance,4 carriers experienced reactivation,and 3 of them had HBeAg-negative hepatitis at the last follow-up.Of the 8 initially HBeAg-negative children,2 had HBeAg-negative hepatitis,and 6 were inactive carriers.Of the 4 children with cirrhosis,2 had hepatocellular carcinoma(HCC)and remained alive and 2 lost the histological features of cirrhosis in adulthood.Two patients with HBeAg-negative hepatitis and 1 with cirrhosis had experienced drug abuse.At the end of follow-up,15 of the 89 initially HBeAg-positive patients and 2 of 8 initially HBeAg-negative children had cleared hepatitis B surface antigen.In conclusion,the overall prognosis for chronic hepatitis B in horizontally infected Caucasian children is favorable;however,some patients progress to HCC and HBeAg-negative hepatitis.Long-term monitoring is important,as is counseling on cofactors of liver damage,such as alcohol and drug abuse. | Bortolotti F. Guido M. Bartolacci S. 王铮 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，9： | 2 |
| 9 | Dilated intercellular spaces as a marker of oesophageal damage: comparatibe results in gastro-oesophageal reflux disease with or without bile reflux显示文摘 | Calabrese C Fabbri A Bortolotti M | 2003 | Aliment Pharmacol Ther2003，18，5： | 1 |
| 10 | Surgical pathology of disease of the mitral valve with special reference to lesions promoting valver incompetence显示文摘 | TURRY M THIENE G BORTOLOTTI U | 1989 | Int J Cardiol1989，22，： | 1 |
| 11 | Reversibility of GERD ultrastructural alterations and relief of symptoms afer omeprazole treatment显示文摘 | Calabrese C Bortolotti M Fabbri A | 2005 | Am J Gastroenterol2005，100，： | 1 |
| 12 | Amphiphilic association systems for amphotericin B delivery 显示文摘 | Esposito E Bortolotti F Menegatti E | 2003 | Int J Pharm2003，260，2： | 1 |
| 13 | Measurement of gastric emptying time by real-time ultrasonography显示文摘 | Bolondi L Bortolotti M Santi V | 1985 | Gastroenterology1985，89，4： | 1 |
| 14 | An updated follow - up of chronic hepatitis C after three decades of observation in pediatric patients cured of malignancy显示文摘 | Cesaro S Bortolotti F Petris MG | 2010 | Pediatr Blood Cancer2010，55，1： | 1 |
| 15 | HLA-G may predict the disease course in patients'with early rheumatoid arthritis显示文摘 | Rizzo R Farina I Bortolotti D | 2013 | Hum Immunol2013，74，4： | 1 |
| 16 | Long term effect of alpha interferon in children with chronic hepatitis B显示文摘 | Bortolotti F Jara P Barbera C et at | 2000 | Gut2000，46，5： | 1 |
| 17 | Government Control of Privatized Firms 显示文摘 | Bortolotti B Faccio M | 2009 | Review of Financial Studies2009，22，8： | 1 |
| 18 | Developments in core analysis by NMR measurements 显示文摘 | Borgia G C Bortolotti V Brancolini A | 1996 | Magnet Resonance Imaging1996，14，78： | 1 |
| 19 | Evaluation and optimization of capillary zone electrophoresis with different dynamic capillary coatings for the determination of carbohydrate-deficient transferrin in human serum显示文摘 | Kuhn M Bortolotti F | 2002 | J Chromatogr A2002，979，： | 1 |
| 20 | Experience with the 'da Vinci' robotic system for thymectomy in patients with myasthenia gravis:report of 33 cases显示文摘 | Rea F Marulli G Bortolotti L | 2006 | Ann Thorac Surg2006，81，2： | 1 |
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