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| 1 | Biomarkers in colorectal cancer: Current clinical utility and future perspectives显示文摘Colorectal cancer(CRC) is a major cause of cancer death worldwide. CRC has poor prognosis and there is a crucial need for new diagnostic and prognostic biomarkers to avoid CRC-related deaths. CRC can be considered a sporadic disease in most cases(75%-80%), but it has been suggested that crosstalk between gene mutations(i.e., mutations of BRAF, KRAS, and p53 as well as microsatellite instability) and epigenetic alterations(i.e., DNA methylation of Cp G island promoter regions) could play a pivotal role in cancer development. A number of studies have focused on molecular testing to guide targeted and conventional treatments for patients with CRC, sometimes with contrasting results. Some of the most useful innovations in the management of CRC include the possibility to detect the absence of KRAS, BRAF, NRAS and PIK3 CA gene mutations with the subsequent choice to administer targeted adjuvant therapy with anti-epidermal growth factor receptor antibodies. Moreover, CRC patients can benefit from tests for microsatellite instability and for the detection of loss of heterozygosity of chromosome 18 q that can be helpful in guiding therapeutic decisions as regards the administration of 5-FU. The aim of this review was to summarize the most recent evidence on the possible use of genetic or epigenetic biomarkers for diagnosis, prognosis and response to therapy in CRC patients. | Marco Vacante Antonio Maria Borzì Francesco Basile Antonio Biondi | 2018 | World Journal of Clinical Cases2018，6，15： | 18 |
| 2 | MicroRNA expression profiles in Kaposi\'s sarcoma显示文摘 | Catrina Ene AM Borze I Guled M | 2014 | Pathol Oncol Res2014，20，1： | 1 |
| 3 | Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos-and histology-related chan- ges in lung cancer 显示文摘 | Nymark P Guled M Borze I | 2011 | Genes Chromosomes Cancer2011，50，8： | 1 |
| 4 | Cytokine responseafter percutaneous coronary intervention in stable angina:effect of selective glycoprotein Ⅱ b/Ⅲa receptor antagonism显示文摘 | Borz A W Lengenfelder B JacobsM | | 0，，： | 1 |
| 5 | Integrative analysis of microRNA,mRNA and aCGH data reveals absbestos-and histology-related changes in lung cancer显示文摘 | Penny Nymark Mohamed Guled Loana Borze | 2011 | Genes Chromosmes and Cancer2011，50，： | 1 |
| 6 | CanGEM: mining gene eopy number changes in cancer 显示文摘 | Scheinin I Myllykangas S Borze I | 2008 | Nucleic Acids Res2008，36，： | 1 |
| 7 | Transapical aortic valve implantation in Rouen:Four years' experience with the Edwards transcatheter prosthesis显示文摘 | Litzler PY Borz B Smail H | 2012 | Archives of Cardiovascular Diseases2012，，03： | 1 |
| 8 | Optimal control formulation fordetermining optical flow显示文摘 | Borz' 1 A Ito K Kuniseh K | 2002 | SIAM Journal of Scientific Compu- ting 242002，，： | 1 |
| 9 | JAK2V617F mutation and spontaneous megakaryocytic or erythroid colony formation in patients with essential thrombocythaemia (ET) or polycythaemia vera (PV)显示文摘 | Mustjoki S Borze I Lasho TL | 2009 | Leuk Res2009，33，1： | 1 |
| 10 | MicroRNA profiling predicts survival in anti-EGFR treated chemorefractory metastatic colorectal cancer patients with wild-type KRAS and BRAF 显示文摘 | Mosakhani N Lahti L Borze I | 2012 | Cancer Genet2012，205，： | 1 |
| 11 | Integrative analysis of microR- NA, mRNA and aCGH data reveals asbestos-and histology-related changes in lung cancer显示文摘 | Nymark P Guled M Borze I | 2011 | Genes Chromosomes Cancer2011，50，： | 1 |
| 12 | Comparing FEM-BEM and FEM-DBCI for open-boundary electrostatic field problems显示文摘 | AIELLO G ALFONZETTI S BORZG | 2007 | The European Physica Journal Applied Physics2007，39，2： | 1 |
| 13 | Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokines显示文摘 | Borzì RM Mazzetti I Cattini L | | 0，，08： | 1 |
| 14 | MicroRNA expression profiles in Kaposi's sarcoma 显示文摘 | Catrina Ene AM Borze I Guled M | 2014 | Pathol Oneol Res2014，20，1： | 1 |
| 15 | Integrative analysis of microRNA,mRNA and a CGH data reveals asbestos-and histology-related changes in lung cancer显示文摘 | Nymark P Guled M Borze I | 2011 | Genes Chromosomes Cancer2011，50，8： | 1 |
| 16 | Spleno-renal distal and proximal shunts for hypersplenism due to hepatic cirhosis显示文摘 | Bancu S Borz C Popescu G | 2007 | Chirurgia(Bucur)2007，102，6： | 1 |
| 17 | Integrated analysis of gene copy number, copy neutral LOH, and microRNA pro- files in adult acute lymphoblastic leukemia显示文摘 | Ninomiya S Tyybtkinoja A Borze I | 2012 | Cytogenet Ge- nome Res2012，136，4： | 1 |
| 18 | Zoonotic transmission of reassortant porcine G4P rotaviruses in Hungarian pediatric patients identified sporadically over a 15 year period显示文摘 | Papp H Borz 6 k R Farkas S | 2013 | Infect Genet Evol2013，19，1： | 1 |
| 19 | Classification of particulates on pulsed-laser deposited Y-Ba-Cu-O films 显示文摘 | Proyer S Stangl E Borz M | 1996 | Physica C1996，96，： | 1 |
| 20 | Does residual aortic regurgitation after transcatheter aortic valve implantation increase mortality in all patients? The importance of baseline natriuretic peptides显示文摘 | Borz B Durand E Godin M | 2014 | Int J Cardiol2014，173，3： | 1 |
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