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| 1 | Epigenetic regulation: methylation of histone and non-histone proteins显示文摘Histone methylation is believed to play important roles in epigenetic memory in various biological processes. However, questions like whether the methylation marks themselves are faithfully transmit- ted into daughter cells and through what mechanisms are currently under active investigation. Previ- ously, methylation was considered to be irreversible, but the recent discovery of histone lysine de- methylases revealed a dynamic nature of histone methylation regulation on four of the main sites of methylation on histone H3 and H4 tails (H3K4, H3K9, H3K27 and H3K36). Even so, it is still unclear whether demethylases specific for the remaining two sites, H3K79 and H4K20, exist. Furthermore, be- sides histone proteins, the lysine methylation and demethylation also occur on non-histone proteins, which are probably subjected to similar regulation as histones. This review discusses recent pro- gresses in protein lysine methylation regulation focusing on the above topics, while referring readers to a number of recent reviews for the biochemistry and biology of these enzymes. | LAN Fei1 & SHI Yang 2 1 Department of Biology, Constellation Pharmaceuticals, 148 Sidney Street, Cambridge, MA 02139, USA 2 Department of Pathology, Harvard Medical School, 77 Ave Louise Pasteur, Boston MA, 02115, USA | 2009 | Science China(Life Sciences)2009，52，4： | 27 |
| 2 | Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc^(min) mice显示文摘AIM:To investigate whether Recql5,a DNA helicase that plays an important role in the maintenance of genome integrity,is a tumor suppressor in the gastrointestinal tract in mice.METHODS:We generated cohorts of both Recql5-proficient and Recql5-deficient Apcmin/+mice and compared the tumor susceptibility in their gastrointestinal tracts.RESULTS:Recql5 deficiency in Apcmin/+mice resulted in a significant increase in the tumor incidence in both the colon(P=0.0162)and the small intestine(P<0.01).These findings have provided the first genetic evidence for a tumor suppression role of Recql5 in the gastrointestinal tract of mice.Importantly,since mouse Recql5 and human RECQL5 are highly conserved,these findings also suggest that RECQL5 may be a tu-mor suppressor for human colon cancer.CONCLUSION:Recql5 has a tumor suppression role in the mouse gastrointestinal tract. | Yiduo Hu,Xincheng Lu,Guangbin Luo,Department of Genetics,Case Comprehensive Cancer Center and University Hospitals of Cleveland,Case Western Reserve University,Cleveland,OH 44106,United States Yiduo Hu,Department of Cancer Biology,Dana-Farber Cancer Institute,Boston,MA 02115,United States | 2010 | World Journal of Gastroenterology2010，16，12： | 6 |
| 3 | Intrinsic control of axon regeneration显示文摘Spinal cord injury disrupts the connections between the brain and spinal cord, often resulting in the loss of sensory and motor function below the lesion site. The most important reason for such permanent functional deficits is the failure of injured axons to regenerate after injury. In principle, the functional recovery could be achieved by two forms of axonal regrowth: the regeneration of lesioned axons which will reconnect with their original targets and the sprouting of spared axons that form new circuits and compensate for the lost function. Our recent studies reveal the activity of the mammalian target of rapamycin (mTOR) pathway, a major regulator of new protein synthesis, as a critical determinant of axon regrowth in the adult retinal ganglion neurons[1]. In this review, I summarize current understanding of the cellular and molecular mechanisms that control the intrinsic regenerative ability of mature neurons. | Zhigang He F.M. Kirby Neurobiology Center, Children’s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. | 2010 | The Journal of Biomedical Research2010，24，1： | 6 |
| 4 | Inducible resistance to Fas-mediated apoptosis in B cells显示文摘Apoptosis produced in B cells through Fas (APO-1, CD95) triggering is regulated by signals derived from other surface receptors: CD40 engagement produces upregulation of Fas expres. sion and marked susceptibility to Fas-induced cell death, whereas antigen receptor engagement, or IL-4R engagement, inhibits Fas killing and in so doing induces a state of Fas-resistance, even in otherwise sensitive, CD40-stimulated targets. Surfaceim. munoglobulin and IL-4R utilize at least partially distinct pathways to produce Fas-resistance that differentially depend on PKC and STAT6, respectively. Further, surface immunoglob- 'lin signaling for inducible Fas-resistance bypasses Bib, requires NF-GB, and entails new macromolecular synthesis. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic gene products, Bcl-xL and FLIP, and a novel anti-apoptotic gene that encodes FAIM (Fas Apoptosis Inhibitory Molecule). faim was identified by differential display and exists in two alternatively spliced forms; maim-S is broadly expressed, but faim-L expression is tissue-specific. The FAIM sequence is highly evolu tionarily conserved, suggesting an important role for this molecule throughout phylogeny. Inducible resistance to Fas killing is hypothesized to protect foreign antigen-specific B cells during potentially hazardous interactions with FasL-bearing T cells, whereas autoreactive B cells fail to become Fas-resistant and are deleted via Fas-dependent cytotoxicity. Inadvertent or aberrant acquisition of Fas-resistance may permit autoreactive B cells to escape Fas deletion, and malignant lymphocytes to impede anti-tumor immunity. | ROTHSTEIN THOMAS L Departments of Medicine and Microbiology, and the Evans Memorial Department of Clinical Research, Boston University Medical Center, Boston, MA, USA | 2000 | Cell Research2000，10，4： | 4 |
| 5 | Hardness of enamel exposed to Coca-Cola and artificial saliva显示文摘 | Devlin H Bassiouny MA Boston D | 2006 | J Oral Reha- bil2006，33，1： | 1 |
| 6 | Hierarchical control of heart- assist devices显示文摘 | Boston JR Antaki JF Simaan MA | 2003 | IEEE Robot Autom Mag2003，10，1： | 1 |
| 7 | Minimally invasive estimation of systemic vascular parameters 显示文摘 | Yu YC Boston JR Simaan MA | 2001 | Ann Biomed Eng2001，29，7： | 1 |
| 8 | FINE PARTICULATE AIR POLLUTION: EPIDEMIOLOGIC BASIS FOR AIR QUALITY STANDARDS显示文摘In proposing a new ambient air quality standard for fine particulate air pollution in 1997, the U.S. Environmental Protection Agency was responding to a wealth of epidemiologic evidence. At the same time, it was recognized that there was little supporting evidence from toxicologic or controlled human exposure studies. The epidemiologic findings were questioned as only statistical associations without a plausible biological mechanism or an identified causal agent in the complex mix of pollutants characterized as fine particles. In response to these weaknesses in the scientific evidence, a series of research initiatives have been undertaken in exposure assessment, controlled animal and human exposures, and assessments of free-living populations. Key papers have been subjected to comprehensive review and replication. It is now four to seven years since the seminal papers suggesting adverse health effects of fine particles were published. Have these results held up over time? Have they been confirmed by other investigators in other populations? Do we have insights into the biologic mechanisms? Have the specific toxic characteristics of particles been identified? | Douglas W. Dockery Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 USA | 2001 | 安全2001，22，3： | 1 |
| 9 | Cholesterol and mental disorder 显示文摘 | Boston PF Dursun SM Reveley MA | 1996 | Br J Psychiatry1996，169，： | 1 |
| 10 | Arginine: New and Exciting Developments for an“Old”Amino Acid显示文摘Arginine (2-amino-5-guanidino pentanoic acid) was shown in 1895 by Hedin to be present in the proteins of horn. Metabolic nitrogen balance studies, conducted in 1957 by Rose in human adults and in 1959 by Snyderman and coworkers in young infants, revealed that a dietary source of this amino acid was not an obligatory requirement for growth and maintenance of nitrogen homeostasis in healthy individuals. Hence, It was initially classified as a non-essential (dispensable) amino acid and, perhaps, for reasons of this classification arginine did not receivc the earlier atteniion it now deserves, in relation to an understanding of the nutritional biochemistry and physiology of its metabolism in humans subjects. However, there is currently a considerable interest in the cellular and tissue functions, as well as clinical, therapeutic significance, of arginine. In this paper we review the multiple functions of arginlne, including its role in the L-arginine-nitric oxide pathway,cellular regeneration, immune function, protein synthesis and protein breakdown. We then consider some in vivo aspects of the physiology of arginine metabolism, which varies greatly among eukaryotes, with particular reference to humans. Against this background, studies of arginine in the nutrition of humans under various pathophysiological conditions are reviewed briefly. Finally, a new, updated concept for the metabolic basis for the 'conditional essentiality' of arginine is | LOUIS BEAUMIER LETICIA CASTILLO YONG-MING YU ALFRED M. AJAMI AND VERNON R. YOUNG(Laboratory of Human Nutrition, School of Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA Shriners Burns Institute,Boston, MA, 02114 USA mass Tra | 1996 | Biomedical and Environmental Sciences1996，9，2： | 1 |
| 11 | Cholsterol and mental disorder显示文摘 | Boston PF Dursun SM Reveley MA | 1996 | Br J Psychiatry1996，169，6： | 1 |
| 12 | Cholesterol and mental disorder显示文摘 | Boston PF Dursun SM Reveley MA | 1996 | Br J Psychiatry1996，169，： | 1 |
| 13 | On the Role of Bond Function in Nonlinear Optical Property Calculations for HF,HCI,LiH,H_2O and NH_3显示文摘OntheRoleofBondFunctioninNonlinearOopticalPropertyCalculationsforHF,HCI,LiH,H_2OandNH_3LIZhi-ru.,TAOFu-ming,PANYuh-Kang,FENGJi... | Zhi-ru., TAO Fu-ming, PAN Yuh-Kang, FENG Ji-Kang, SUN Chia-Chung(Department of Chemistry, Jilin University, Changchun, 130023, China Department of Chemiststry, Harvard University, Cambraidge, MA 02138 , USA Department of Chemistry, Boston College, Ches | 1997 | Chemical Research in Chinese Universities1997，13，3： | 1 |
| 14 | Tholesterol and mental disorder 显示文摘 | Boston PF Dursun SM Reveley MA | 1996 | Br Psychiatry1996，169，6： | 1 |
| 15 | Commercial Applications of Wireless Sensor Networks Using ZigBee显示文摘 | Wheeler A Ember Corp Boston MA | 2007 | IEEE Communications Magazine2007，45，4： | 1 |
| 16 | Simulation studies of high-latitude magnetospheric boundary dynamics显示文摘Magnetic reconnection at the high-latitude magnetopause is studied using 2.5-dimensional Hall-MHD simulation. Concentric flow vortices and magnetic islands appear when both Hall effect and sheared flow are considered. Plasma mixing across the magnetopause occurs in the presence of the flow vortices. Reconnected structure generated in the vicinity of the subsolar point changes its geometry with increasing flow shear while moving to high latitudes. In the presence of flow shear, with the Hall-MHD reconnection a higher reconnection rate than with the traditional MHD is obtained. The out-of-plane components of flow and magnetic field produced by the Hall current are redistributed under the action of the flow shear, which makes the plasma transport across the boundaries more complicated. The simulation results provide some help in understanding the dynamic processes at the high latitude magnetopause. | PU Zuyin1, SHI Quanqi1,3, XIAO Chijie1, FU Suiyan1, ZHANG Hui1,2, ZONG Qiugang2 & LIU Zhenxing3 1. School of Earth and Space Sciences, Peking University, Beijing 100871, China 2. Center for Space Physics, Boston University, 725 Commonwealth Avenue, Boston, MA 02215, USA 3. Center for Space Science and Application Research, Chinese Academy of Sciences, Beijing 100080, China | 2004 | Science China(Technological Sciences)2004，47，4： | 1 |
| 17 | Cholsterol and mental disorder显示文摘 | Boston PF Dursun SM Reveley MA | 1996 | Br J Psychiatry1996，169，： | 1 |
| 18 | Multimodality Therapy of Esophageal Cancer显示文摘 | Cameron D Wright MD Boston MA | 1999 | Chest1999，116，： | 1 |
| 19 | Minimally invasive estimation of systemic vascular parameters for artificial heart control显示文摘 | Yu YC Boston JR Simaan MA | 2002 | Control Engineering Practice2002，10，3： | 1 |
| 20 | Mechanisms of axon regeneration显示文摘ailure of regeneration in injured axons accounts for permanent functional deficits after CNS injury.Thus,there has been a tremendous need to understand the mechanisms underlying regeneration failure.Previously,a predominant hypothesis held that extrinsic inhibitory factors in the adult CNS environment prevent injured axons from re-growth.However,blocking these inhibitory activities genetically led to little or no axon regeneration in vivo,suggesting that removing inhibitory activities alone is | Zhigang He(F.M.Kirby Neurobiology Center,Children’s Hospital,and Department of Neurology,Harvard Medical School,300 Longwood Avenue,Boston,MA 02115,USA) | 2010 | 中国病理生理杂志2010，26，A10： | 0 |
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