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| 1 | Is ARFI elastography reliable for predicting fibrosis severity in chronic HCV hepatitis?显示文摘AIM:To determine whether acoustic radiation force impulse(ARFI) elastography is a reliable method for predicting fibrosis severity in patients with chronic hepatitis C virus(HCV) hepatitis.METHODS:We performed a multicenter study including 274 subjects with HCV chronic hepatitis in which we compared ARFI with liver biopsy(LB).In each patient we performed LB(evaluated according to the Metavir score) and ARFI measurements(using a Siemens Acuson S2000TM ultrasound system:10 valid measurements were performed and median values were calculated and expressed in meters/second(m/s).RESULTS:A direct,strong,correlation(Spearman r = 0.707) was found between ARFI measurements and fibrosis(P < 0.0001).For predicting the presence of fibrosis(F ≥ 1 Metavir),significant fibrosis(F ≥ 2),severe fibrosis(F ≥ 3) and cirrhosis(F = 4),the cutoff values of 1.19,1.21,1.58 and 1.82 m/s were determined,respectively,liver stiffness measurements had 73%,84%,84% and 91% Se respectively;93%,91%,94%,90% Sp,respectively;with AUROCs of 0.880,0.893,0.908 and 0.937,respectively.CONCLUSION:ARFI measurement is a reliable method for predicting the severity of fibrosis in HCV | Ioan Sporea Roxana Sirli Simona Bota Carmen Fierbinteanu-Braticevici Alina Popescu Radu Badea Monica Lupsor Ana Petrisor Mirela Dnil | 2011 | World Journal of Radiology2011，3，7： | 24 |
| 2 | Severe adverse events during antiviral therapy in hepatitis C virus cirrhotic patients: A systematic review显示文摘AIM: To identify severe adverse events (SAEs) leading to treatment discontinuation that occur during antiviral therapy in hepatitis C virus (HCV)-infected cirrhotic patients. METHODS: We identified all the articles published prior to December 2011 in the PubMed, Medline, Lilacs, Scopus, Ovid, EMBASE, Cochrane and Medscape databases that presented these data in cirrhotic patients. These studies evaluated the rate of SAEs leading to discontinuation of standard care treatment: Pegylated interferon (PegIFN) alpha 2a (135-180 μg/wk) or PegIFN alpha 2b (1 or 1.5 μg/kg per week) and ribavirin (800-1200 mg/d). Patients with genotype 1 + 4 underwent treatment for 48 wk, whereas those with genotypes 2 + 3 were treated for 24 wk.RESULTS: We included 17 papers in this review, comprising of 1133 patients. Treatment was discontinued due to SAEs in 14.5% of the patients. The most common SAEs were: severe thrombocytopenia and/or neutropenia (23.2%), psychiatric disorders (15.5%), decompensation of liver cirrhosis (12.1%) and severe anemia (11.2%). The proportion of patients who needed to discontinue their therapy due to SAEs was significantly higher in patients with Child-Pugh class B and Cvs those with Child-Pugh class A: 22%vs 11.4% (P = 0.003). A similar discontinuation rate was found in cirrhotic patients treated with PegIFN alpha 2a and those treated with PegIFN alpha 2b, in combination with ribavirin: 14.2%vs 13.7% (P = 0.96). The overall sustained virological response rate in cirrhotic patients was 37% (95%CI: 33.5-43.1) but was significantly lower in patients with genotype 1 + 4 than in those with genotype 2 + 3: 20.5% (95%CI: 17.9-24.8) vs 56.5% (95%CI: 51.5-63.2), (P < 0.0001). CONCLUSION: Fourteen point five percent of HCV cirrhotic patients treated with PegIFN and ribavirin needed early discontinuation of therapy due to SAEs, the most common cause being hematological disorders. | Simona Bota Ioan Sporea Roxana Sirli Alina Popescu Adriana Maria Neghinǎ Mirela Dǎnilǎ Mihnea Strǎin | 2013 | World Journal of Hepatology2013，5，3： | 6 |
| 3 | Value of acoustic radiation force impulse elastography for the assessment of ascites syndrome显示文摘AIM:To assess the feasibility of performing acoustic radiation force impulse(ARFI) elastography in patients with ascites and its predictive value for the cirrhotic or non-cirrhotic etiology of ascites.METHODS:Our study included 153 patients with ascites,mean age 58.8 ± 13.1 years.One hundred and fifteen(75.2%) patients had ascites in the context of cirrhosis,29(18.9%) had non-cirrhotic ascites(diagnosed by clinical,ultrasound,endoscopic and/or laparoscopic criteria) and in 9(5.9%) cases we could not establish the etiology of ascites.We performed 10 ARFI measurements and the median value was calculated and expressed in meters/second(m/s).Among the 29 patients with non-cirrhotic ascites were included:20 laparoscopically demonstrated peritoneal carcinomatosis with histological confirmation,7 acute pancreatitis with ascites which later resolved,and one case each of lymphatic ascites and ascites in the context of a liver abscess.In 11 of the 20 patients with peritoneal carcinomatosis,the liver structure was homogenous in the ultrasound examination and in 9 patients the ultrasound exam revealed liver metastases.RESULTS:We could not obtain valid ARFI measurements in 5 patients(3.2%).The mean liver stiffness measurements by means of ARFI were statistically significantly higher in patients with cirrhotic ascites than in those with non-cirrhotic ascites:3.04 ± 0.70 vs 1.45 ± 0.59 m/s(P < 0.001).For a cut-off value of 1.8 m/s for predicting cirrhosis(and ascites in the context of cirrhosis),as obtained in a previous study,ARFI had 98.1% sensitivity,86.2% specificity,96.4% positive predictive value,92.5% negative predictive value and 95.6% accuracy for predicting cirrhotic ascites.For a cut-off value of 1.9 m/s the accuracy was 94.9% and for a 2 m/s cut-off value it was 92.8%.CONCLUSION:ARFI elastography is feasible in most patients with ascites and has a very good predictive value for the cirrhotic or non-cirrhotic etiology of ascites. | Simona Bota Ioan Sporea Roxana Sirli Alina Popescu Mirela Dǎnilǎ Mǎdǎlina Sendroiu | 2011 | World Journal of Radiology2011，3，8： | 2 |
| 4 | Infection Probability Score (IPS) :a Method to Help Assess the Probability of Infection in Critically ill Patients显示文摘 | Peres Bota D Melot C Lopes Ferreira F | 2003 | Crit Care Med2003，31，： | 1 |
| 5 | Serial evaluation of the SO-FA score to predict outcome in critically ill patients显示文摘 | Ferreira F L Bota D P Bross A | | 0，，： | 1 |
| 6 | Long-term outcome in ICU patients:what about quality of life显示文摘 | Garcia Lizana F Peres Bota D De Cubber M | | 0，，08： | 1 |
| 7 | Diffusive and metabolic limitations to photosynthesis under drought and salinity in C3, plants显示文摘 | Flexas J Bota J Loreto F Comic G Sharkey T D | 2004 | Plant Biology2004，6，3： | 1 |
| 8 | Body tempera ture alterations in the critically ill显示文摘 | Peres Bota D Lopes Ferreira F Melot C | 2004 | Intensive Care Med2004，30，： | 1 |
| 9 | Characterization of adsorptive anti hydrophobie properties of silicalite-1, ZSM-5,TS-1 and bela zeoliles by TPD techniques显示文摘 | Serrano D P Calleja G Botas J A | 2007 | Separation and Purification Technology2007，54，： | 1 |
| 10 | Catalytic Conversion of Rapeseed Oil for the Production of Raw Chemicals, Fuelsand Carbon Nanotubes over Ni-Modified Nanocrystalline and Hierar- chicalZSM-5显示文摘 | Botas 1 A Serrano D P Garcla A | 2014 | ApplCatal A2014，145，2： | 1 |
| 11 | Hydrogen production by methane decomposition Origin of the catalytic activity of carbon materials显示文摘 | Serrano D P Botas J A Fierro J L G | | 0，，06： | 1 |
| 12 | Sulfation of tyrosine 174 in the human C3aR is essential for binding of C3a anaphylatoxin显示文摘 | Gao J Choe H Bota D | 2003 | J Biol Chem2003，278，37： | 1 |
| 13 | Body tempera- ture alterations in the critically ill 显示文摘 | Peres Bota D Lopes Ferreira F M61ot C | 2004 | Intensive Care Med2004，30，5： | 1 |
| 14 | Serial e- valuation of the SOFA score to predict outcome in critically ill patients 显示文摘 | FERREIRA F L BOTA D P BROSS A | 2001 | JAMA2001，286，： | 1 |
| 15 | The multiple organ dysfunction score (MODS) versus the sequential organ failure assessment (SOFA) score in outcome prediction 显示文摘 | Bota D P Melot C Ferreira F L | 2002 | Inten- sive care medicine2002，28，11： | 1 |
| 16 | Population based inci-dence of type 2 diabetes in northern Spain : the AsturiasStudy 显示文摘 | Valdes S Botas D Elgado E | 2007 | Diabetes Care2007，30，9： | 1 |
| 17 | Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10,a specific receptor for the chemokine Eskine显示文摘 | Jarmin DI Rits M Bota D | 2000 | J Immunol2000，164，7： | 1 |
| 18 | Cutting edge:identification of the orphan receptor G-protein-coupled receptor2 as CCR10,a specific receptor for the chemokine ESkine显示文摘 | Jarmin DI Rits M Bota D | 2000 | J Immunol2000，164，7： | 1 |
| 19 | Epidemiology of central nerv- ous system metastases 显示文摘 | Alexandru D Bota Linskcy ME | 2012 | Prog Neurol Surg2012，25，： | 1 |
| 20 | 显示文摘 | Serrano D P Calleja G Botas J A | 2007 | Separation and Purification Technology2007，54，： | 1 |
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