|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 2 | Biosynthesis and ultrasonic degradation of bacterial poly ( gamma-glutamic acid ) 显示文摘 | Perez-Camero G Congregado F Bou J J | 1999 | Biotechnol Bioeng1999，63，1： | 1 |
| 3 | Biochemical and genetic characteristics of TEM-29B,a novel extended-spectrum beta-lactamase显示文摘 | Bou G Martlnez B J Cervero G | 1999 | FEMS Microbiol Lett1999，174，1： | 1 |
| 4 | OXA-24,a novel class D betalactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain显示文摘 | Oliver A Martinez-Beltran J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 5 | l Comparison of nebu lized budeson ide and oral predn iso lone with p lacebo in th e treatment of acu te exacerbations of chron ic obstructive pulmon ary disease:a randomized controlled tria显示文摘 | Maltais F Os tinelli J Bou rbeau J et a | 2002 | l Am J Resp ir Crit CareM ed2002，165，： | 1 |
| 6 | OXA-24,a novel class D beta-lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain显示文摘 | Bou G Oliver A Martinez-Beltran J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 7 | Delta opioid receptors mediatechemotaxis in bone marrow-derived dendritic cells显示文摘 | Bénard A BouéJ Chapey E | 2008 | J Neuroim-munol2008，197，1： | 1 |
| 8 | Cloning,nucleotide sequencing,and analysis of the gene encoding an AmpC β-lactamase in Acinetobacter baumannii显示文摘 | Bou G Martínez-Beltrán J | 2000 | Antimicrob Agents Chemother2000，44，2： | 1 |
| 9 | OXA-24,a novel class Acineto-bacter baumannii clinical strain显示文摘 | Bou G Oliver A Martrinez J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 10 | Myocardialbridging and milking effect of the left anterior descending coronary artery:normal variant or obstruction显示文摘 | Nob le J Bou rassaMG Pettderdc R | | 0，，： | 1 |
| 11 | Oxa 24,a novel class D beta lactamase with carbapenemase activity in an Axinetobacter baumannii clinical strain显示文摘 | OLIBER A MARTINEZ BELTRAN J | 2006 | Antimicrob Agents Chenother2006，44，6： | 1 |
| 12 | OXA- 24, a novel class D beta- lac-tamase with carbapenemase activity in an Acinetobacter baumannil clinical strain 显示文摘 | Bou G Oliber A Martinez- Behran J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 13 | Molecular and cellular biology of cholinesterases显示文摘 | Massoulie J Pezzementi L Bou S | 1993 | Porg Neurobiol1993，41，： | 1 |
| 14 | OXA-24,a novel class D beta-lactamase with carbapenemase activity in an acinetobacter baumannii clinical strain显示文摘 | Bou G Olive A Martinez-Beltr J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 15 | Biosynthesis and ultrasonic degradation of bacterial poly(γ-glutamic acid) 显示文摘 | Perez-Camero G Congregado F Bou J J | 1999 | Biotechnol Bioeng1999，63，： | 1 |
| 16 | OXA-24,a novel class D be- ta-lactamase with carbapenemase activity in an Aeinetobacter bau-mannii clinical strain显示文摘 | Bou G Oliver A Martinez-Beltrdn J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 17 | OXA - 24, a novel class D beta - lacta- mase with carbapenemase activity in an Acinetobacter baumannii clinicalstrain 显示文摘 | Bou G Oliber A Martinez - Beltran J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 18 | OXA 24, a novel class D β-lactamase with carbapenemase activity in an Acinetobacter banmannii clinical strain显示文摘 | Bou G Oliver A Martinez-Behrone J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 19 | OXA-24,a novel class D beta-lactamase with carbapenemase activity in an Acinetobacter baumannil clinical strain显示文摘 | Bou G Oliber A Martinez-Behran J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 20 | The interaction of gibberellins and photoperiod in the control of potato tuberization显示文摘 | Martinez-Garcta J F Garcia-Martinez J L Bou J | 2002 | J Plant Growth Regul2002，20，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员