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| 1 | Stem cell treatment and cerebral palsy: Systemic review and meta-analysis显示文摘BACKGROUND Perinatal complications may result in life-long morbidities,among which cerebral palsy(CP)is the most severe motor disability.Once developed,CP is a nonprogressive disease with a prevalence of 1-2 per 1000 live births in developed countries.It demands an extensive and multidisciplinary care.Therefore,it is a challenge for our health system and a burden for patients and their families.Recently,stem cell therapy emerged as a promising treatment option and raised hope in patients and their families.AIM The aim is to evaluate the efficacy and safety of stem cell treatment in children with CP using a systematic review and meta-analysis METHODS We performed a systematic literature search on PubMed and EMBASE to find randomized controlled clinical trials(RCT)investigating the effect of stem cell transplantation in children with CP.After the review,we performed a randomeffects meta-analysis focusing on the change in gross motor function,which was quantified using the gross motor function measure.We calculated the pooled standardized mean differences of the 6-and/or 12-mo-outcome by the method of Cohen.We quantified the heterogeneity using the I-squared measure.RESULTS We identified a total of 8 RCT for a qualitative review.From the initially selected trials,5 met the criteria and were included in the meta-analysis.Patients’population ranged from 0.5 up to 35 years(n=282).We detected a significant improvement in the gross motor function with a pooled standard mean difference of 0.95(95%confidence interval:0.13-1.76)favoring the stem cell group and a high heterogeneity(I2=90.1%).Serious adverse events were rare and equally distributed among both intervention and control groups.CONCLUSION Stem cell therapy for CP compared with symptomatic standard care only,shows a significant positive effect on the gross motor function,although the magnitude of the improvement is limited.Short-term safety is present and further highquality RCTs are needed. | Simone Eggenberger Céline Boucard Andreina Schoeberlein Raphael Guzman Andreas Limacher Daniel Surbek Martin Mueller | 2019 | World Journal of Stem Cells2019，11，10： | 8 |
| 2 | Synthesis of Branched Poly(butylene succinate):Structure Properties Relationship显示文摘一系列 poly 分叉(丁烯 succinate )(PBS ) 也就是与几分叉代理人被综合 trimethylol 丙烷(TMP ) ,苹果酸酸, trimesic 酸,柠檬性的酸和甘油 propoxylate。分叉的聚合物的结构被秒和 1 H-NMR。结晶化上的分叉的代理人结构的效果也被调查并且玩一个重要角色。等温的研究证明甘油 propoxylate 能充当一个起核心作用的代理人。由对比, TMP 的高内容扰乱了链的整齐并且妨碍了 PBS 的结晶化。从非等温的运动学习,甘油 propoxylate 显著地由于分叉的代理人的灵活结构增加了结晶化率,这被发现。一个第二等的成核被观察,甘油 propoxylate 归因于在在主要结晶化形成的雏晶之间包括的非结晶的部分的结晶化。链拓扑学通过 rheological 调查被获得,综合聚合物显示出线性、随机分叉的 PBS 的混合物的典型行为。分支的加入为电影刮改进了 PBS 的 processability 在产生电影的裂缝的申请和模量和压力显著地被增加。 | Marie Vandesteene Nicolas Jacquel Rene Saint-Loup Nadège Boucard Christian Carrot Alain Rousseau Francoise Fenouillot | 2016 | Chinese Journal of Polymer Science2016，34，7： | 3 |
| 3 | Chronic aquatic environmental risks from exposure to human pharmaceuticals显示文摘 | Crane M Watts C Boucard T | 2006 | Sci Total Environ2006，367，： | 1 |
| 4 | Chronic aquatic envi- ronmental risks from exposure to human pharmaceuti- cals 显示文摘 | Crane M Watts C Boucard T | 2006 | Science of the Total Environment2006，367，1： | 1 |
| 5 | The use of physical hydrogels of chitosan for skin regeneration following third-degree burns显示文摘 | Boucard N Viton C Agay D | 2007 | Biomaterials2007，28，24： | 1 |
| 6 | Haemolymph metabolic variables in relation to eyestalk ablation and gonad development of Pa- cific white shrimp Litopenaeus vannamei Boone显示文摘 | Arcos G F Ibarra A M Vazquez Boucard C | 2003 | Aquaculture Research2003，34，9： | 1 |
| 7 | Increased heart rate var- iability and executive performance after aerobic training in the elderly 显示文摘 | Albinet C T Boucard G Bouquet C A | 2010 | Eur J Appl Physiol2010，109，4： | 1 |
| 8 | Processing speed and executive functions in cognitive aging : how to disentangle their mu- tual relationship显示文摘 | ALBINET C T BOUCARD G BOUQUET C A | 2012 | Brain and Cognition2012，79，1： | 1 |
| 9 | Angiotensin Ⅱ is bound to both receptors ATj and AT2, parallel to thetransmembrane domains and in an extended form显示文摘 | Deraet M Pdhakova L Boucard A J | 2002 | Can J Physiol Pharmacol2002，80，5： | 1 |
| 10 | Changes in corticalgrey matter density associated with long -standing retinal visual fielddefects显示文摘 | Boucard CC Hemowo AT Maguire RP’ | 2009 | Brain2009，132，7： | 1 |
| 11 | The use of physical hydrogels of chitosan for skin regeneration following third-degree burns显示文摘 | Boucard N Viton C Agay D | 2007 | Biomat erials2007，28，24： | 1 |
| 12 | Developmental changes in concentrations of vitellin, vitellogenin, and lipid in hemolymph, hepatopanereas, and ovaries from different ovarian stages of Indian white prawn Fenneropenaeus indicus 显示文摘 | Vazquez Boucard C G Levy P Ceccaldi H J | 2002 | J Exp Mar Biol Eeol2002，281，： | 1 |
| 13 | Chronic aquatic environmental risks from exposure to human pharmaceuticals显示文摘 | CRANE M WATTS C BOUCARD T | 2006 | Sci Total Environ2006，367，1： | 1 |
| 14 | Gold (Ⅲ)-Catalyzed Nucleophilic Substitution of Propargylic Alcohols显示文摘 | Georgy M Boucard V Campagne J | | 0，，41： | 1 |
| 15 | Chronic aquatic environmental risks from exposure to human phar- maceuticals显示文摘 | Mark Crane Chris Watts Tatiana Boucard | 2006 | Science of the Total Environment2006，367，1： | 1 |
| 16 | Photoluminescence of donor-acceptor carbazole-based molecules in amorphous and power forms显示文摘 | ADES D BOUCARD V CLOUTET E | 2000 | Journal of Applied Physics2000，87，10： | 1 |
| 17 | Angiotensin Ⅱ is bound to both receptors AT1 and AT2,parallel to the transmembrane domains and in an extended form显示文摘 | Deraet M Rihakova L Boucard A | 2002 | Can J Physiol Pharmacol2002，80，5： | 1 |
| 18 | New Aspects of the Formation of Physical Hydrogels of Chitosan in a Hydroalcoholic Medium显示文摘 | Boucard N Viton C Domard A | | 0，，06： | 1 |
| 19 | A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to α- and β-Neurexins显示文摘 | Boucard AA Chubykin AA Comoletti D | 2005 | Neuron2005，48，2： | 1 |
| 20 | Haemo lymph metabolic variables in relation to eyestalk ablation and gonad development of Pacific white shrimp Litope- naeus vannamei Boone显示文摘 | Farcos G Ibarra A M Vazquez Boucard C | 2003 | Aquaculture Research2003，34，9： | 1 |
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