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| 1 | Malignant biliary obstruction:From palliation to treatment显示文摘Malignant obstruction of the bile duct from cholan-giocarcinoma,pancreatic adenocarcinoma,or other tumors is a common problem which may cause debilitating symptoms and increase the risk of subsequent surgery.The optimal treatment-including the decision whether to treat prior to resection-depends on the type of malignancy,as well as the stage of disease.Preoperative biliary drainage is generally discouraged due to the risk of infectious complications,though some situations may benefit.Patients who require neoadjuvant therapy will require decompression for the prolonged period until attempted surgical cure.For pancreatic cancer patients,self-expanding metallic stents are superior to plastic stents for achieving lasting decompression without stent occlusion.For cholangiocarcinoma patients,treatment with percutaneous methods or nasobiliary drainage may be superior to endoscopic stent placement,with less risk of infectious complications or failure.For patients of either malignancy who have advanced disease with palliative goals only,the choice of stent for endoscopic decompression depends on estimated survival,with plastic stents favored for survival of < 4 mo.New endoscopic techniques may actually extend stent patency and patient survival for these patients by achieving local control of the obstructing tumor.Both photodynamic therapy and radiofrequency ablation may play a role in extending survival of patients with malignant biliary obstruction. | Brian R Boulay Aleksandr Birg | 2016 | World Journal of Gastrointestinal Oncology2016，8，6： | 24 |
| 2 | Managing malignant biliary obstruction in pancreas cancer: Choosing the appropriate strategy显示文摘Most patients with pancreatic cancer develop malignant biliary obstruction.Treatment of obstruction is generally indicated to relieve symptoms and improve morbidity and mortality.First-line therapy consists of endoscopic biliary stent placement.Recent data comparing plastic stents to self-expanding metallic stents(SEMS)has shown improved patency with SEMS.The decision of whether to treat obstruction and the means for doing so depends on the clinical scenario.For patients with resectable disease,preoperative biliary decompression is only indicated when surgery will be delayed or complications of jaundice exist.For patients with locally advanced disease,self-expanding metal stents are superior to plastic stents for long-term patency.For patients with advanced disease,the choice of metallic or plastic stent depends on life expectancy.When endoscopic stent placement fails,percutaneous or surgical treatments are appropriate.Endoscopic therapy or surgical approach can be used to treat concomitant duodenal and biliary obstruction. | Brian R Boulay Mayur Parepally | 2014 | World Journal of Gastroenterology2014，20，28： | 18 |
| 3 | Evolving role of the endoscopist in management of gastrointestinal neuroendocrine tumors显示文摘Neuroendocrine tumors(NETs) are uncommon gastrointestinal neoplasms but have been increasingly recognized over the past few decades. Luminal NETs originate from the submucosa of the gastrointestinal tract and careful endoscopic exam is a key for accurate diagnosis. Despite their reputation as indolent tumors with a good prognosis,some NETs may have aggressive features with associated poor long-term survival. Management of NETs requires full understanding of tumor size,depth of invasion,local lymphadenopathy status,and location within the gastrointestinal tract. Staging with endoscopic ultrasound or cross-sectional imaging is important for determining whether endoscopic treatment is feasible. In general,small superficial NETs can be managed by endoscopic mucosal resection and endoscopic submucosal dissection(ESD). In contrast,NETs larger than 2 cm are almost universally treated with surgical resection with lymphadenectomy. For those tumors between 11-20 mm in size,careful evaluation can identify which NETs may be managed with endoscopic resection. The increasing adoption of ESD may improve the results of endoscopic resection for luminal NETs. However,enthusiasm for endoscopic resection must be tempered with respect for the more definitive curative results afforded by surgical treatment with more advanced lesions. | Cemal Yazici Brian R Boulay | 2017 | World Journal of Gastroenterology2017，23，27： | 9 |
| 4 | Occlusion Rate and Complications of Plastic Biliary Stent Placement in Patients Undergoing Neoadjuvant Chemoradiotherapy for Pancreatic Cancer With Malignant Biliary Obstruction显示文摘 | Brian R. Boulay Timothy B. Gardner Stuart R. Gordon | 2010 | Journal of Clinical Gastroenterology2010，，： | 2 |
| 5 | 用CFRP加固预裂钢筋混凝土梁的疲劳特征的研究(英文)显示文摘通过对碳纤维织物加固的预裂钢筋混凝土(RC)梁的三点弯曲试验,给出了其疲劳特征实验研究结果.RC梁(200 mm×150 mm×700 mm)被施加预载直到所产生的两裂缝的宽度之和为0.7 mm,然后用碳纤维织物进行抗弯和抗剪加固.碳纤维织物在裂缝处的联结作用,可使RC梁在静载和疲劳载荷作用下其裂缝宽度减小,且在碳纤维和钢筋间产生应力重分布.实验结果表明,通过碳纤维织物加固的预裂钢筋混凝土梁,其刚度、极限结构强度及极限疲劳强度都得到明显改善. | 吴泽仪 J.-L. Clément C. Boulay J.-L. Tailhan | 2007 | 南昌工程学院学报2007，26，3： | 2 |
| 6 | Phosphorylation of key serine residues is required for internalization of the complement 5a(C5a) anaphytoxin receptor via a beta-arrestin,dynamin,and clathrin-dependent pathway显示文摘 | Braun L Chiristophe T Boulay F | 2003 | J Biol Chem2003，278，6： | 2 |
| 7 | 显示文摘 | Boulay JL Paul WE | 1992 | J Biol Chem1992，267，20： | 1 |
| 8 | On the trail of a cognitive enhancer for the treatment of schizophrenia显示文摘 | Stip E Chouinard S Boulay LJ | 2005 | Prog Neuropsychopharmacol Biol Psychiatry2005，29，4： | 1 |
| 9 | Mineralogy and Sedimentology of Pleistocene Sediment in the South China Sea (ODP Site 1144)显示文摘 | Boulay S Colin C Trentesaux A | 2003 | Proceedings of Ocean Program Scientific Results2003，184，： | 1 |
| 10 | Involve- ment of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vas- cular smooth muscle cells显示文摘 | MONET M FRANCOEUR N BOULAY G | 2012 | J Biol Chem2012，287，17： | 1 |
| 11 | Loss of hypermethylated in cancer 1(HIC1)in breast cancer cells contributes to stress-induced migration and invasion throughβ-2 adrenergic receptor(ADRB2)misregulation显示文摘 | Boulay G Malaquin N Loison I | 2012 | J Biol Chem2012，287，8： | 1 |
| 12 | What does it take to manage volunteers显示文摘 | Du Boulay C | 1996 | Australia Journal on Volunteering1996，，10： | 1 |
| 13 | Thrombin induces endothelial type]] activation in vitro: IL- 1 and TNF-alpha-independent IL- 8 secretion and E - selection expression显示文摘 | Kaplansi G Fabrlgoule M Boulay V | 1997 | J Immunol1997，158，11： | 1 |
| 14 | Smad7 is a prognostic marker in patients with colorectal cancer显示文摘 | Boulay JL Mild G Lowy A | 2003 | Int J Cancer2003，104，4： | 1 |
| 15 | The glycine transporter-1 inhibitor SSR103800 displays a selective and specific antipsychotic-like profile in normal and transgenic mice 显示文摘 | Boulay D Bergis O Avenet P | 2010 | Neuropsycho- pharmacology2010，35，2： | 1 |
| 16 | Training of submaximal working capacity: frequency, intensity, duration, and their interactions显示文摘 | BOUCHARD C BOULAY M THIBAULT M C | 1980 | J Sports Med Phys Fitn1980，20，1： | 1 |
| 17 | Cardiac calcification in adult hemodialysis patients:A link between ESRD and cardiovascular disease显示文摘 | Raggi P Boulay A Chasan-Taber S | 2002 | J Am Coll Cardiol2002，39，4： | 1 |
| 18 | Metastatic lymph node 64 (MLN64), a gene overexpressed in breast cancers, is regulated by Sp/KLF transcription factors 显示文摘 | Alpy F Boulay A Moog-Lutz C | 2003 | Oncogene2003，22，24： | 1 |
| 19 | A novel P300 - based brain-computer interface stimulus presentation paradigm: Moving beyond rows and columns显示文摘 | Townsend G LaPallo BK Boulay CB | 2010 | Clinical Neurophysiology2010，121，7： | 1 |
| 20 | Metalloproteinase-9 in induced sputum correlates with the severity of the late allergen-induced asthmatic response显示文摘 | BOULAY M E PRINCE P DESCHESNES F | 2004 | Respiration2004，71，3： | 1 |
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