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| 1 | Surgicat management of axis'traumatic spondylolisthesis(Hangman's fracture)显示文摘 | Colli BO Carlotti CG Jr | 2004 | Arq Neuropsiquiatr2004，62，3： | 1 |
| 2 | Surgical management of axis' traumatic spondylolisthesis (Hangman' s fracture) 显示文摘 | Boullosa JL Colli BO Carlotti CG Jr | 2004 | Arq Neuropsiquiatr2004，62，： | 1 |
| 3 | Women with metabolic syndrome present different autonomic modulation and blood pressure response to an acute resistance exercise session compared with women without metabolic syndrome显示文摘 | Tibana RA Boullosa DA Leicht AS | | 0，，05： | 1 |
| 4 | Molecular evidence for the inverse comorbidity between central nervous system disorders and cancers detected by transcrip- tomic meta-analyses显示文摘 | Ibanez K Boullosa C Tabares-Seisdedos R | 2014 | PLoS Genet2014，10，10： | 1 |
| 5 | The reac- tion force on a Helmholtz resonator driven at high sound pressureamplitudes显示文摘 | Ricardo R Boullosa FelipeOrduiiaBustamante | 1992 | Am J Phys1992，60，： | 1 |
| 6 | Cardiac autonomic adaptations in elite spanish soccer players during preseason 显示文摘 | Boullosa DA Abreu L Nakamura FY | 2013 | Int J Sports Physiol Perform2013，8，4： | 1 |
| 7 | VSL#3 pmbiotic trealrnent decreases bacterial Iranslocation in rats with cmtt~on teWachloride- induced cirrhosis显示文摘 | S~nchez E Nieto JC Boullosa A | 2015 | Liver Int2015，35，3： | 1 |
| 8 | Effectiveness of pegylated interferon and ribavirin in patients with liver HCV cirrhosis 显示文摘 | Moreno Planas J M Rubio Gonzalez E Boullosa Grana E | 2005 | Transplant Proc2005，37，3： | 1 |
| 9 | Peginterferon and ribavirin in patients with HCV cirrhosis after liver transplantation显示文摘 | Moreno Planas JM Rubio Gonzalez E Boullosa Grafia E | 2005 | Transplant Proc2005，37，5： | 1 |
| 10 | A note on the use of novel thermoacoustic radiators for ultrasonic experi-ments the importance of phase in a focused field显示文摘 | Ricardo R Boullosa Arturo O Santill an | | 0，，： | 1 |
| 11 | VSL 3 probiotic treatment decreases bacterial transloca- tion in rats with carbon tetrachloride-induced cirrhosis 显示文摘 | SaNCHEZ E NIETO J C BOULLOSA A | 2014 | Liver Int2014，，： | 1 |
| 12 | Characterization of acquired nutlin-3 resistant non-small cell lung cancer cells显示文摘Aim:The purpose of this manuscript is to study the potential characteristics of acquired nutlin-3 resistant non-small cell lung cancer cells(NSCLC).Nutlin-3 is an inhibitor of the murine-double minute 2 protein,the main negative regulator of wild type p53,of which several derivatives are currently in clinical development.Methods:A549 NSCLC cells were exposed to increasing concentrations of nutlin-3 for a period of 18 weeks.Monoclonal derivates were cultured,and the most resistance subclone was selected for whole transcriptome analysis.Gene set enrichment analysis was performed on differentially expressed genes between A549 nutlin-3 resistant cancer cells and the parental A549 p53 wild type cancer cells.Relevant findings were validated at the gene,protein and/or functional level.Results:All nutlin-3 resistant subclones acquired mutations in the TP53 gene,resulting in overexpression of the mutant p53 protein.The most resistant subclone was enriched for genes related to epithelial to mesenchymal transition(EMT),resulting in increased migratory and invasive potential.Furthermore,these cells were enriched in genes related to inflammation,tissue remodelling,and angiogenesis.Importantly,expression of several immune checkpoints,including PD-L1 and PD-L2,was significantly upregulated,and cisplatin-induced cell death was reduced.Conclusion:Transcriptome analysis of a highly nutlin-3 resistant A549 subclone shows the relevance of studying(1)resistance to standard of care chemotherapy;(2)secretion of immunomodulating chemo-and cytokines;(3)immune checkpoint expression;and(4)EMT and invasion in nutlin-3 resistant cancer cells in addition to acquired mutations in the TP53 gene. | Christophe Deben Laurie Freire Boullosa Andreas Domen An Wouters Bart Cuypers Kris Laukens Filip Lardon Patrick Pauwels | 2021 | Cancer Drug Resistance2021，4，1： | 0 |
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