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| 1 | Pulmonary fibrosis and emphysema: Is the emphysema type associated with the pattern of fibrosis?显示文摘AIM: To investigate whether the predominant emphysema type is associated with the high resolution computed tomography(HRCT) pattern of fibrosis in combined pulmonary fibrosis and emphysema(CPFE).METHODS: Fifty-three smokers with upper lobe emphysema and lower lobe pulmonary fibrosis on- HRCT-were retrospectively evaluated. Patients were stratified into 3 groups according to the predominant type of emphysema: Centrilobular(CLE), paraseptal(PSE), CLE = PSE. Patients were also stratified into 3 other groups according to the predominant type of fibrosis on HRCT: Typical usual interstitial pneumonia(UIP), probable UIP and nonspecific interstitial pneumonia(NSIP). HRCTs were scored at 5 predetermined levels for the coarseness of fibrosis(Coarseness), extent of emphysema(emphysema), extent of interstitial lung disease(Tot Ext ILD), extent of reticular pattern not otherwise specified(Ret NOS), extent of ground glass opacity with traction bronchiectasis(extG GOBx), extent of pure ground glass opacity and extent of honeycombing. HRCT mean scores, pulmonary function tests, diffusion capacity(DLCO) and systolic pulmonary arterial pressure were compared among the groups.RESULTS: The predominant type of emphysema was strongly correlated with the predominant type of fibrosis. The centrilobular emphysema group exhibited a significantly higher extent of emphysema(P < 0.001) and a lower extent of interstitial lung disease(P < 0.002), reticular pattern not otherwise specified(P < 0.023), extent of ground glass opacity with traction bronchiectasis(P < 0.002), extent of honeycombing(P < 0.001) and coarseness of fibrosis(P < 0.001) than the paraseptal group. The NSIP group exhibited a significantly higher extent of emphysema(P < 0.05), total lung capacity(P < 0.01) and diffusion capacity(DLCO)(P < 0.05) than the typical UIP group. The typical UIP group exhibited a significantly higher extent of interstitial lung disease, extent of reticular pattern not otherwise specified, extent of ground glass opacity with traction bronchiectasis, extent of honeycombing and coarseness of fibrosis(0.039 > P > 0.000). Although the pulmonary arterial pressure was higher in typical UIP group relative to the NSIP group, the difference was not statistically significant.CONCLUSION: In CPFE patients, paraseptal emphysema is associated more with UIP-HRCT pattern and higher extent of fibrosis than centrilobular emphysema. | Anastasia Oikonomou Paraskevi Mintzopoulou Argyris Tzouvelekis Petros Zezos George Zacharis Anastasios Koutsopoulos Demosthenes Bouros Panos Prassopoulos | 2015 | World Journal of Radiology2015，7，9： | 2 |
| 2 | Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome显示文摘 | Bouros D Wells AU Nicholson AG | 2002 | Am J Respir Crit Care Med2002，165，12： | 1 |
| 3 | The clinical significance of serum and bronchoalveolar lavage inflammatory cytokines in patients at risk for acute respiratory distress syndrome 显示文摘 | Bouros D Alexandrakis MG Antoniou KM | 2004 | BMC Pulm Med2004，4，： | 1 |
| 4 | Effects of antifibrotic agents on TGF-beta1, CTGF and IFN-gamma expression in patients with idiopathic pulmonary fibrosis显示文摘 | Tzortzaki EG Antoniou KM Zervou MI Lambiri I Koutsopoulos A Tzanakis N Plataki M Maltezakis G Bouros D Siafakas NM | 2007 | Respir Med2007，101，8： | 1 |
| 5 | Crescentic and ring-shaped opacities: CT features in two cases of bronchiolitis organizing pneumonia (BOOP)显示文摘 | Voloudaki AE Bouros DE Froudarakis ME | 1996 | Acta Radiol1996，37，6： | 1 |
| 6 | Lymphangitis after tuberculintest显示文摘 | Bouros D Niotis M Blatsios V | 1991 | Eur Respir J1991，4，2： | 1 |
| 7 | Effect and safety of my-cophenolate mofetil or sodium in systemic sclerosis-associated interstitial lung disease:a meta-analysis 显示文摘 | Tzouvelekis A Galanopoulos N Bouros E | 2012 | Pulm Med2012，2012，14： | 1 |
| 8 | Association of malignancy with diseases causing interstitial pulmonary changes显示文摘 | Bouros D Hatzakis K Labrakis H | | 0，，： | 1 |
| 9 | Pathogenetic pathways and novel pharmacotherapeutic targets in idiopathic pulmonary fibrosis 显示文摘 | Antoniou K Pataka A Bouros D | 2007 | Pulm Pharmacol Ther2007，20，： | 1 |
| 10 | Intrapleurl streptokinase versus urokinase in the treatment of complicated parapneumonic effusion显示文摘 | Bouros D Schiza S Patsourakis G | 1997 | Am J Respir Crit Care Med1997，155，： | 1 |
| 11 | Ventila- tor-assoeiated pneumonia or endotraeheal tubeassoeiated pneumonia:an approach to the pathogenesis and preven- tive strategies emphasizing the importance of endotrache- al tube显示文摘 | Pneumatikos IA Dragoumanis CK Bouros DE | 2009 | Anesthesiology2009，110，3： | 1 |
| 12 | Bronchoalveolar lavage findings in a young adult with idiopathic pulmonary haemosiderosis and coeliac disease显示文摘 | Bouros D Panagou P Rokkas T | 1994 | Eur Respir J1994，7，： | 1 |
| 13 | Fat embolism syndrome:Clinical exam ination is preferable diagnostic method显示文摘 | Ccorgopoulos D Bouros D | | 0，，： | 1 |
| 14 | Prognostic value of serum tumor markers in patients with lung cancer显示文摘 | Hatzakis KD Froudarakis ME Bouros D | 2002 | Respiration2002，69，1： | 1 |
| 15 | Acute inter-stitial pneumonia显示文摘 | Bouros D Nicholson A C Polychronopoulos V | 2000 | Eur Respir J2000，15，2： | 1 |
| 16 | Angiogenesis in interstitial lung diseases: a pathogenetic hallmark or a bystander?显示文摘 | Tzouvelekis A Anevlavis S Bouros D | 2006 | Respir Res2006，7，： | 1 |
| 17 | Prognostic value of serum tumor markers in patients with lung cancer显示文摘 | Hatzakis KD Froudarakis ME Bouros D | | 0，，： | 1 |
| 18 | Effect of Continuous Positive Airway Pressure Treatment on Serum Cardiovascular Risk Factors in Patients With Obstructive Sleep Apnea-Hypopnea Syndrome显示文摘 | Paschalis Steiropoulos Venetia Tsara Evangelia Nena Christina Fitili Margarita Kataropoulou Marios Froudarakis Pandora Christaki Demosthenes Bouros | 2007 | Chest2007，，： | 1 |
| 19 | Evaluation of inflammatory cytokines in malignamt and benign pleural effusions显示文摘 | Alexangrakis MG Couloclieri SA Bouros D | 2000 | Oncol Rep2000，7，6： | 1 |
| 20 | Pirfenidone for idiopathic pulmonary fibrosis显示文摘 | Bouros D | 2011 | Lancet2011，377，： | 1 |
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