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| 1 | The function and regulation of TET2 in innate immunity and inflammation显示文摘TET2,a member of ten-eleven translocation(TET)family as a-ketoglutarate-and Fe2+-dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine(5mC),has been widely recognized to be an important regulator for normal hematopoiesis especially myelopoiesis.Mutation and dysregulation of TET2 contribute to the development of multiple hematological malignancies.Recent studies reveal that TET2 also plays an important role in innate immune homeostasis by promoting DNA demethylation or independent of its enzymatic activity.Here,we focus on the functions of TET2 in the initiation and resolution of inflammation through epigenetic regulation and signaling network.In addition,we highlight regulation of TET2 at various molecular levels as well as the correlated inflammatory diseases,which will provide the insight to intervene in the pathological process caused by TET2 dysregulation. | Boyi Cong Qian Zhang Xuetao Cao | 2021 | Protein & Cell2021，12，3： | 6 |
| 2 | Identification of immune-activating metabolite for enhancing T cell therapy of cancer显示文摘T cell activation by antigens is followed by rapid growth,expansion,and differentiation to perform effector functions against infection or tumor.Upon antigen stimulation,T-cell receptor(TCR)signaling triggers the remodeling of metabolic activities to meet the demand of energy and nutrients for activating and launching effective immune responses[1]. | Boyi Cong Zenghui Cui Xuetao Cao | 2021 | Cancer Communications2021，41，7： | 1 |
| 3 | Control-oriented modeling of a high-aspect-ratio flying wing with coupled flight dynamics显示文摘The flight-structural dynamics of a high-aspect-ratio wing challenge the flight control design.This paper develops a reduced model of coupled dynamics with stability consideration.The structural dynamics are formulated with dihedrals,and the central loads drive the deformation.The control-oriented model with essential coupled dynamics is formulated.Modal sensitivity anal-ysis and input–output pairing are performed to identify the control structure.Besides,an example of flight control design is provided to discuss the necessity of considering structural dynamics in controller design.Analytical coupled flight dynamics provide a system-theoretic approach for sta-bility and facilitate model-based control techniques.Simulation results reveal the characteristics of flight-structural coupled dynamics and demonstrate that the influence of flexible modes should be considered in control design,especially in lateral dynamics. | Cong NIU Xiutian YAN Boyi CHEN | 2023 | Chinese Journal of Aeronautics2023，36，4： | 0 |
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