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| 1 | Study of penetration mechanism of labrasol on rabbit cornea by Ussing chamber, RT-PCR assay, Western blot and immunohistochemistry显示文摘Labrasol, as a non-ionic surfactant, can enhance the permeation and absorption of drugs, and is extensively used in topical, transdermal, and oral pharmaceutical preparations as an emulsifier and absorption enhancer. Recent studies in our laboratory have indicated that labrasol has a strong absorption enhancing effect on different types of drugs in vitro and in vivo. This study was performed to further elucidate the action mechanism of labrasol on the corneal penetration. In this research, the fluorescein sodium, a marker of passive paracellular transport of tight junction, was selected as the model drug to assess the effect of labrasol on in vitro corneal permeability. To investigate the continuous and real-time influence of labrasol on the membrane permeability and integrity, the Ussing chamber system was applied to monitor the electrophysiological parameters. And, furthermore, we elucidated the effect of labrasol on excised cornea at the molecular level by application of RT-PCR, Western blot, and immunohistochemical staining. The results indicated that labrasol obviously enhance the transcorneal permeability of fluorescein sodium, and the enhancement was realized by interacting with and down-regulating the associated proteins, such as Factin, claudin-1 and β-catenin, which were contributed to cell-cell connections, respectively. | Pan Guo Nan Li Lili Fan Jun Lu Boying Liu Bing Zhang Yumei Wu Zhidong Liu Jiawei Li Jiaxin Pi Dongli Qi | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 2 |
| 2 | A novel method for nonlinear singular fourth order foupoint boundary value prob- lems 显示文摘 | LI Xiuying WU Boying | 2011 | Computers and Mathematics with Applica- tions2011，62，： | 1 |
| 3 | A new algorithm for a class of linear nonlocal boundary value problems based on the reproducing kernel method显示文摘 | WU Boying LI Xiuying | 2011 | Applied Mathe- matics Letters2011，24，： | 1 |
| 4 | Application of reproducing kernel method to third three-point boundary value problems显示文摘 | Wu Boying Li Xiuying | 2010 | Applied Mathematics and Computation2010，，217： | 1 |
| 5 | Histological Study of the Liver Pigmentation of Chinese Fire-bellied Newt (Cynops orientalis) During Activity and Hibernation Periods显示文摘The pigmentation in the liver of Chinese fire-bellied newt(Cynops orientalis) was described during two periods of the annual cycle(summer activity and winter hibernation). A large number of melanin granules were gathered into clusters and distributed unevenly inside the pigment cells. Liver pigmentation(melanin content) was found unstable,varying during the annual cycle. During the hibernation period,pigmentation accumulation was shown to increase in the liver of the Chinese fire-bellied newt. Hepatocytes during the active period are approximately 14.64% larger than those in the hibernation period,while the nucleus is approximately 7.43% bigger during the active period when compared with that during the hibernation period. These findings indicate that variation in pigment distribution and hepatocyte morphology in Chinese fire-bellied newt liver may be an ecologically adaptive strategy to the adverse physiological conditions during hibernation. | Zhaohui XIE Haijun LI Boying LI Linna CHENG Anfang ZHAO Cunshuan XU | 2012 | Asian Herpetological Research2012，3，4： | 0 |
| 6 | A compartment model and numerical analysis of circulatory economy显示文摘This paper describes an industrial structure and its equation system of a circular economy for material circulation and builds a system dynamic model for resources recycling utilization based on Compartment Model Theory.A circulation multiplier and its computational formula are defined for measuring the efficiency of resources recycling utilization.The simulated results indicate that the resources recycling utilization can not only realize the amount accumulation of natural resources and improve the resources recycling efficiency but can minimize discharges into natural environment by means of adjustment to each compartment parameter in the circular economy. | Zhongzhi Yang Pengzhi Kong Boying Li Bo Chao | 2019 | Journal of Management Analytics2019，6，1： | 0 |
| 7 | A New Prediction System Based on Self-Growth Belief Rule Base with Interpretability Constraints显示文摘Prediction systems are an important aspect of intelligent decisions.In engineering practice,the complex system structure and the external environment cause many uncertain factors in the model,which influence the modeling accuracy of the model.The belief rule base(BRB)can implement nonlinear modeling and express a variety of uncertain information,including fuzziness,ignorance,randomness,etc.However,the BRB system also has two main problems:Firstly,modeling methods based on expert knowledge make it difficult to guarantee the model’s accuracy.Secondly,interpretability is not considered in the optimization process of current research,resulting in the destruction of the interpretability of BRB.To balance the accuracy and interpretability of the model,a self-growth belief rule basewith interpretability constraints(SBRB-I)is proposed.The reasoning process of the SBRB-I model is based on the evidence reasoning(ER)approach.Moreover,the self-growth learning strategy ensures effective cooperation between the datadriven model and the expert system.A case study showed that the accuracy and interpretability of the model could be guaranteed.The SBRB-I model has good application prospects in prediction systems. | Yingmei Li Peng Han Wei He Guangling Zhang Hongwei Wei Boying Zhao | 2023 | Computers, Materials & Continua2023，，5： | 0 |
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