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| 1 | Real-life chromoendoscopy for dysplasia surveillance in ulcerative colitis显示文摘AIM To evaluate the use of chromoendoscopy for surveillance of ulcerative colitis in a real-life community hospital setting.METHODS Patients with extensive ulcerative colitis, having disease duration of more than 8 years and who presented between the years of 1999 to 2013, were offered enrolment in this single cohort prospective study. All participants underwent standard bowel preparation with sodium phosphate and chromoendoscopy. Two expert endoscopists, novice to chromoendoscopy, evaluated each segment of the colon with standarddefinition colonoscopes after spray application of 0.4% indigo carmine. All observed lesions were recorded and evaluated before being removed and/or biopsied. In addition, nontargeted biopsies were taken from each segment of the colon. The dysplasia detection rate and dysplasia detection yield were ascertained. RESULTS A total of 21 neoplastic lesions(2 carcinomas, 4 of high-grade dysplasia and 15 of low-grade dysplasia) and 27 nondysplastic lesions were detected in 16 of the total 67 patients(70% male; median disease duration: 17 years; median age at diagnosis: 25 years; 92% aminosalicylate-treated). The dysplasia detection rate was 10.5%(7/67 patients). The dysplasia detection yield was 20.8%(10/48) for targeted biopsies and 3.5%(11/318) for nontargeted biopsies. The sensitivity and specificity for the macroscopic evaluation of neoplasia using chromoendoscopy were 48% [95% confidence interval(CI): 26%-70%] and 96%(95%CI: 93%-98%), respectively. The positive predictive and negative predictive values were 42%(95%CI: 27%-59%) and 97%(95%CI: 95%-98%), respectively. A total of 19/21 dysplastic lesions were detected in mucosa with histologic inflammation.CONCLUSION Chromoendoscopy seems to be of value for dysplasia surveillance of ulcerative colitis in a community hospital setting. The yield of non-targeted biopsies is negligible. | Pasquale Klepp Anita Tollisen Arne Roseth Milada Cvancarova Smastuen Solveig N Andersen Morten Vatn Bjorn A Moum Stephan Brackmann | 2018 | World Journal of Gastroenterology2018，24，35： | 3 |
| 2 | Ripening and senescence of papaya with 1 methylcyclopropene 显示文摘 | Jacomino A P Kluge R A Brackmann A | 2002 | Scientia Agricola2002，59，2： | 1 |
| 3 | Brainstem potentials evoked by electrical stimulation of the cochlear in human subjects 显示文摘 | Starr A Brackmann DE | 1979 | Ann Otol Rhinol Laryngoh1979，88，： | 1 |
| 4 | A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma显示文摘 | Caceres A I Brackmann M Ella M D | 2009 | Proc Natl Acad Sci U S A2009，106，22： | 1 |
| 5 | Controlled atmosphere storage of apples: Cell wall composition and fruit softening显示文摘 | Siddiqui S Brackmann A Streif J | 1996 | J Hortie Sci1996，71，： | 1 |
| 6 | Changes in cu-linary,viscoamylographic and sensory characteristics during rice storage at different temperatures显示文摘 | Kaminski TA Brackmann A Silva LP da | | 0，，： | 1 |
| 7 | Neurotologic skull base surgery in pediatric patients显示文摘 | CUNNINGHAM C D 3rd FRIEDMAN R A BRACKMANN D E | 2005 | Otol Neurotol2005，26，： | 1 |
| 8 | Changes in culinary,viscoamylographic and sensory characteristics during rice storage at different temperatures显示文摘 | Kaminski T A Brackmann A da Silva L P | 2013 | Journal of Stored Products Research2013，53，： | 1 |
| 9 | The mineralogy and the isotopic composition of sulfur in hydrothermal sulphide/sulfate deposits on the East Pacific Rise,21°N latitude显示文摘 | STYRT M M BRACKMANN A J HOLLAND H D | 1981 | Earth Planet Sci Lett1981，53，： | 1 |
| 10 | Investigations into the physiology of volatile aroma production of apple fruits显示文摘 | BANGERTH F STREIF J SONG J BRACKMANN A | 1998 | Acta Horticultunae1998，464，： | 1 |
| 11 | The mineralogy and the isotopic composition of sulfur in hydrothermal sulfide/sulfate deposits on the East Pacific Rise, 21 °N latitude 显示文摘 | Styrt M M Brackmann A J Holland H D Clark B C Pisutha-Arnond V Elridge C S Ohmoto H | 1981 | Earth Planet Sci Lett1981，53，3： | 1 |
| 12 | Effect of Storage under Extremely Low Oxygen on the Volatile Composition of 'Royal Gala' Apples显示文摘 | BOTH V BRACKMANN A THEWES F R | 2014 | Food Chemistry2014，156，： | 1 |
| 13 | Brain stem potentials evoked by electrical stimulation of the cochlea in human subjects显示文摘 | Starr A Brackmann DE | 1979 | Ann Otol Rhinol Laryngol1979，88，41： | 1 |
| 14 | Brainstem potentials evoked by electrical stimulation of the cochlear in human subjects显示文摘 | Starr A Brackmann DE | 1979 | Ann Otol1979，88，： | 1 |
| 15 | Controlled atmosphere storage of apples: cell wall composition and fruit softening显示文摘 | SIDDIQUI B S BRACKMANN A STREIF J | 1996 | Journal of Horticultural Science1996，71，4： | 1 |
| 16 | Spinal epidural haematoma in haemophilia A显示文摘 | Schmitz A Wallny T Sommer T Brackmann H Schulze-Bertelsbeck D Effenberger W | | 0，，： | 1 |
| 17 | Prognostic factors for hearing preservation in vestibular schwannoma surgery 显示文摘 | BRACKMANN D E OWENS R M FRIEDMAN R A | 2000 | Am J Otol2000，21，3： | 1 |
| 18 | A sensoryneuronal ion channel essential for airway inflammation and hyperre-activity in asthma显示文摘 | CACERES A I BRACKMANN M ELIA M D | 2009 | Proc Natl Acad Sci2009，106，22： | 1 |
| 19 | A warning on venous liga- tion for pulsatile tinnitus 显示文摘 | Jackler RK Brackmann DE Sismanis A | 2001 | Otol Neurotol2001，22，3： | 1 |
| 20 | The mineralogy and the isotopic composition of sulfur in hydrothermal sulfide/sulfate deposits on the East Pacific Rise, 21^o N latitude 显示文摘 | Styrt M M Brackmann A J Holland H D | 1981 | Earth planet Sci lett1981，53，： | 1 |
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