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| 1 | Dying by fire: noncanonical functions of autophagy proteins in neuroinflammation and neurodegeneration显示文摘Neuroinflammation and neurodegeneration are key components in the establishment and progression of neurodegenerative diseases including Alzheimer's Disease(AD). Over the past decade increasing evidence is emerging for the use of components of the canonical autophagy machinery in pathways that are characterized by LC3 lipidation yet are distinct from traditional macro-autophagy. One such pathway that utilizes components of the autophagy machinery to target LC3 to endosomes, a process termed LC3-associated endocytosis(LANDO), has recently been identified and regulates neuroinflammation. Abrogation of LANDO in microglia cells results in a propensity for elevated neuroinflammatory cytokine production. Using the well-established 5 xFAD model of AD to interrogate neuroinflammatory regulation, impairment of LANDO through deletion of a key upstream regulator Rubicon or other downstream autophagy components, exacerbated disease onset and severity, while deletion of microglial autophagy alone had no measurable effect. Mice presented with robust deposition of the neurotoxic AD protein β-amyloid(Aβ), microglial activation and inflammatory cytokine production, tau phosphorylation, and aggressive neurodegeneration culminating in severe memory impairment. LANDO-deficiency impaired recycling of receptors that recognize Aβ, including TLR4 and TREM2. LANDO-deficiency alone through deletion of the WD-domain of the autophagy protein ATG16 L, revealed a role for LANDO in the spontaneous establishment of age-associated AD. LANDO-deficient mice aged to 2 years presented with advanced ADlike disease and pathology correlative to that observed in human AD patients. Together, these studies illustrate an important role for microglial LANDO in regulating CNS immune activation and protection against neurodegeneration. New evidence is emerging that demonstrates a putative linkage between pathways such as LANDO and cell death regulation via apoptosis and possibly necroptosis. Herein, we provide a review of the use of the autophagy machinery in non-canonical mechanisms that alter immune regulation and could have significant impact in furthering our understanding of not only CNS diseases like AD, but likely beyond. | Alexis D.Rickman Addison Hilyard Bradlee L.Heckmann | 2022 | Neural Regeneration Research2022，17，2： | 3 |
| 2 | Intake of fruits,vegetables,and dairy products in early childhood and subsequent blood pressure change显示文摘 | Moore LL Singer MR Bradlee ML | 2005 | Epidemiology2005，16，1： | 1 |
| 3 | Folate Intake and the Risk of Neural Tube Defects: An Estimation of Dose-Response显示文摘 | Lynn L. Moore M. Loring Bradlee Martha R. Singer Kenneth J. Rothman Aubrey Milunsky | 2003 | Epidemiology2003，，2： | 1 |
| 4 | Intake of fruits, vegetables, and dairy products in early childhood and subsequent blood pressure change显示文摘 | Moore LL Singer MR Bradlee ML | 2005 | Epidemiology2005，16，1： | 1 |
| 5 | BMI and waist circumference as predictors of lifetime colon cancer risk in Framingham Study adults显示文摘 | Moore LL Bradlee ML Singer MR | 2004 | Int JObesRelat Metab Disord2004，28，4： | 1 |
| 6 | Dietary Approaches to Stop Hypertension (DASH) eating pattern and risk of elevated blood pressure in adolescent girls显示文摘 | Moore LL Bradlee ML Singer MR | 2012 | Br J Nutr2012，108，9： | 1 |
| 7 | Folate intake and the risk of neural tube defects an estimation of dose-response显示文摘 | Moore LL Bradlee ML Singer MR | 2003 | Epidemi- ology2003，14，2： | 1 |
| 8 | Folate intake and the risk of neural tube defects an estimation of dose-response显示文摘 | Moore LL Bradlee ML Singer MR | 2003 | Epidemiology2003，14，2： | 1 |
| 9 | Folate intake and the risk of neural tube defects an estimation of dose-response显示文摘 | Moore LL Bradlee ML Singer MR | 2003 | Epidemiology2003，14，2： | 1 |
| 10 | Low dairy intake in early childhood predicts excess body fat gain显示文摘 | MOORE L L BRADLEE M L GAO D | 2006 | Obesity2006，14，6： | 1 |
| 11 | Does early physi-cal activity predict body fat change throughout childhood?显示文摘 | Moore LL Gao D Bradlee ML | 2003 | Prev Med2003，37，1： | 1 |
| 12 | BMI and waist circumference as predictors of lifetime colon cancer risk in Framingham Study adults显示文摘 | Moore LL Bradlee ML Singer MR | | 0，，： | 1 |
| 13 | Dietary Approaches to Stop Hypertension (DASH) eating pattern and risk of elevated blood pres- sure in adolescent girls显示文摘 | Moore L1 Nil Bradlee Mr Singer | 2012 | Br J Nun''2012，108，9： | 1 |
| 14 | Effects of average childhood dairy intake on adolescent bone health显示文摘 | Moore LL Bradlee ML Gao D | 2008 | J Pediatr2008，153，： | 1 |
| 15 | Health related quality of life in long term survivors of pediatric transplantation显示文摘 | Midgley DE Bradlee TA Donohoe C Kent KP | 2000 | Liver Transp2000，6，3： | 1 |
| 16 | Folate intake and therisk of neural tube defects:an estimation of dose-response显示文摘 | MooreLL Bradlee ML Singer MR | 2003 | Epidemiology2003，14，2： | 1 |
| 17 | Folate intake and the risk of neural tube defects an estimation of dose-response 显示文摘 | Moore LL Bradlee ML Singer MR | 2003 | Epidemiology2003，14，2： | 1 |
| 18 | Integrating register allocation and instruction scheduling for RISCs 显示文摘 | BRADLEE D G HENRY R R | 1991 | ACM SIGARCH Computer Architecture News1991，26，4： | 1 |
| 19 | Folate intake and the risk of neural tubedefects:an estimation of dose-re-sponse显示文摘 | Morre LL Bradlee ML Singer MR | 2003 | Epidemiol ogy2003，14，2： | 1 |
| 20 | Beverage intake in early childhood and change in body fat from preschool to adoles- cence显示文摘 | HASNAIN SR SINGER MR BRADLEE ML | 2014 | Child Obes2014，10，1： | 1 |
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