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| 1 | High-level expression of glycoprotein D by a dominant-negative HSV-1virus augments its efficacy as a vaccine against HSV-1 infection显示文摘 | LU Z BRANS R AKHRAMEYEVA N V | 2009 | J Invest Dermatol2009，129，5： | 1 |
| 2 | Tetrahedron显示文摘 | Brans R Wemicke A Koll P | 1999 | 55(32):9793-98001999，55，32： | 1 |
| 3 | Amantadine for fatigue in multiple sclerosis显示文摘 | Pucci E Branās P D’Amico R | 2007 | Cochrane Database Syst Rev2007，24，00： | 1 |
| 4 | Prevention of genital herpes simplex virus type 1 and 2 disease in mice immunized with a g D-expressing dominant-negative recombinant HSV-1显示文摘 | BRANS R AKHRAMEYEVA N V YAO F | 2009 | J Invest Dermatol2009，129，10： | 1 |
| 5 | Tip position of long-term central venous access devices used for parenter- al nutrition显示文摘 | DeChicco R Seidner D L Bran C | 2007 | JPEN J Parenter Enteral Nutr2007，31，5： | 1 |
| 6 | Immunization with a dominant-negative recombinant Herpes Simplex Virus(HSV)type 1 protects against HSV-2 genital disease in guinea pigs显示文摘 | BRANS R YAO F | 2010 | BMC Microbiol2010，10，： | 1 |
| 7 | Optimization of the membrane and pore design for micro-machined membranes 显示文摘 | Brans G van der Sman R G M Schro C G P H | 2006 | Journal of Membrane Science2006，278，12： | 1 |
| 8 | The effect of cognitive behavior therapy in patients with rheumatoid arthritis 显示文摘 | Kraaimaat FW Brans MR Geenen R | 1995 | Behav Res Ther1995，33，5： | 1 |
| 9 | Mach's principle and relativistic theory of gravitation 显示文摘 | Brans C Dicke R H | 1961 | Phys Rev1961，124，： | 1 |
| 10 | Effects of limestone dust accumulation on lateral growth of forest trees显示文摘 | Bran& C J Rhoades R W | 1973 | Environmental Pollution1973，4，3： | 1 |
| 11 | Potential nitrification rate as a tool for screening toxicity in metal-contaminated soils显示文摘 | SMOLDERS E BRANS K COPPENS F MERCKX R | | 0，，11： | 1 |
| 12 | Laboratory experiments on sequential scour/ deposition and their application to the development of banded vege-tation 显示文摘 | Bryan R B Bran S E | 1999 | Catena1999，37，12： | 1 |
| 13 | Mach's principle and a relativistic theory of gravitation 显示文摘 | Brans C H Dicke R H | 1961 | Phys Rev1961，124，： | 1 |
| 14 | Membrane fractionation of milk: state of the art and challenges 显示文摘 | BRANS G SCHROEN C VAN DER SMAN R BOOM R | 2004 | Journal of Membrane Science2004，243，： | 1 |
| 15 | In vitro-in vivo studies on anti-trypanosomal potentials of Zapoteca portoricensis显示文摘Objective:Aqueous extracts of Zapoteca portoricensis are used traditionally as antidiarrhea agent and in the treatment of diverse gastrointestinal disorders here in Nigeria specifically,the southern part.Similarly,the aqueous extract of the plant is also used traditionally as anticonvulsant,antispasmodic and in the treatment of tonsillitis.Recently too,the anti-inflammatory and antimicrobial activities of the methanol extracts of the root of Zapoteca portoricensis was reported.In this research,we are set to investigate the trypanocidal activity of Zapoteca portoricensis.Methods:The methanol extract of the root of Zapoteca portoricensis was investigated for both in vitro and in vivo trypanocidal activity following established models.In summary,phytochemical analysis was carried out on both the crude powdered root and on the methanol extract following standard procedures. The oral acute toxicity test(LD50 ) of the crude methanol extract was determined according to the method described by Lorke(1983).Albino mice(17g-21g) of either sex were used.The methanol extract was suspended in 3%v/v tween 85 and administered orally at doses of 10 mg/kg,100 mg/kg and 1 000 mg/kg to three groups of mice(n = 3 ).The animals were observed for 24 hours.Based on the result obtained in this initial test,doses of 4 mg/kg,6 mg/kg,and 8 mg/kg were administered to three different mice.The LD50 was calculated as the geometric mean of the lowest dose killing a mouse and the highest dose showing no death.The invivo /in-vitro antitrypanosomal evaluations were carried out in experimental animals and tissue cell culture respectively. Results:The result of the in vitro studies shows the inhibitive concentration-50(IC-50) against Trypanosoma brucei rhodesiense(T.b.rhodesiense) to be 0.372 mg/kg,while the control drug melarsoprol was 0.006 mg/kg.On Trypanosoma brucei brucei(T.cruzi),the IC-50 is 6.42 mg/kg against 0.87 of the reference drug Benznidazole.The cytotoxicity on L-6 cells exhibited an IC-50 of 0.039 6 mg/kg against the reference drug,podophyllotoxin of 0.01 mg/kg.However,the in vivo study shows that the extract,at the administered doses,could not exhibit appreciable reduction of parasitemia and hence resulted to the death of test animals. Conclusion:The present data suggests that Zapoteca portoricensis could yield useful leads for the development of potentially potent antitrypanocides. | Nwodo NJ Omeje EO Bran R | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，1： | 1 |
| 16 | Immunization with a dominant-negative recom- binant Herpes Simplex Virus (HSV) type 1 protects against HSV-2 genital disease in guinea pigs 显示文摘 | Brans R Feng Yao | 2010 | BMC Microbiol2010，，10： | 1 |
| 17 | Ultraviolet B radiationand reactive oxygen species modulate interleukin-31 expressionin T lymphocytes, monocytes and dendritic cells 显示文摘 | Cornelissen C Brans R Czaja K | 2011 | Derma-tol2011，165，5： | 1 |
| 18 | Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder显示文摘 | van der Schot AC Vonk R Brans RG | | 0，，02： | 1 |
| 19 | Para-phenylenediamine and allergic sensitization: risk modification by N-acetyltransferase 1 and 2 genotypes 显示文摘 | Blomeke B Brans R Coenraads PJ | 2009 | Br J Dermatol2009，161，5： | 1 |
| 20 | A multi-addressable photochromic 1,2-dithienyl cyclopentene-phenoxy naphthacene-quinone hybrid显示文摘 | Myles A J Wigglesworth T J Bran& N R | 2003 | Advanced Materials2003，15，9： | 1 |
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