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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Neurofibromatosis diagnosed on CT with MR correlation显示文摘 | Arazi-Kleinmann T YM Brand N | 2002 | Eur J Radiol2002，42，1： | 1 |
| 3 | Fusion between a novel k ruppel- like zinc finger gene, and the retinoic acid recept or-locus duet o a variant t ( 11; 17) transl oeati on as sociat ed with acute promyeloeytic leukemia显示文摘 | Chen Z Brand N J Chen A | 1993 | EMBOJ1993，12，3： | 1 |
| 4 | Abiotic nitrogen reduction on the early Earth显示文摘 | BRANDES J A BOCTOR N Z CODY G D | 1998 | Nature1998，395，： | 1 |
| 5 | NADPH oxidases in cardiovascular disease显示文摘 | Brandes RP Weissmann N Schr(o)der K | 2010 | Free Radic Biol Med2010，49，： | 1 |
| 6 | Surface pressure measurements on a body subject to vortex wake interaction显示文摘 | Brand A Komerath N M McMahon H M | 1989 | AIAA Journal1989，27，5： | 1 |
| 7 | Structural analysis and evaluation of the genes related to aldosterone synthesis in hypertension显示文摘 | Brand E Chatelain N Mulatero P | 1998 | Hypertension1998，32，： | 1 |
| 8 | Structural analysis and evaluation of the aldo sterone synthase gene in hypertension 显示文摘 | Brand E Chatelain N M ulatero P | 1998 | Hypertension1998，32，1： | 1 |
| 9 | Antigen-pressing cells and keratinocytes express interleukin-12 in allergic contact dermatitis显示文摘 | Yawalkar N Egli F Brand CU | 2000 | Contact Dermatitis2000，42，1： | 1 |
| 10 | Isolation and characterization of the human cardiac troponin I gene(TNNI3)显示文摘 | Bhavsar P Brand N Yacoub M | | 0，，： | 1 |
| 11 | NADPH oxidases incardiocascular disease显示文摘 | Brandes RP Weissmann N Schroder K | 2010 | Free Radic Biol Med2010，49，5： | 1 |
| 12 | Crosspresenting human gamma delta T cells induce robust CD8+alpha beta T cell responses显示文摘 | Brandes M Willimann K Bioley G Lévy N Eberl M Luo M TampéR Lévy F Romero P Moser B | 2009 | Proc Natl Acad Sci USA2009，106，7： | 1 |
| 13 | Cognitive and emotional characteristics of alexithymia 显示文摘 | Larsena JK Brand N Bennond B | 2003 | J Psychosom Res2003，54，6： | 1 |
| 14 | A conserved family of genes relat- ed to the testis determining gene, SRY显示文摘 | Denny P Swift S Brand N | 1992 | Nucleic Acids Res1992，20，11： | 1 |
| 15 | Estrogen induces repression of the breast cancer and salivary gland expression gene in an estrogen receptor alpha-dependent manner显示文摘 | Bretschneider N Brand H Miller N | 2008 | Cancer Res2008，68，1： | 1 |
| 16 | A conserved family of genesre- lated to the testis determining gene SRY显示文摘 | Denny P Swift S Brand N | 1992 | Nucleic Acids Res1992，20，11： | 1 |
| 17 | Targeted gene expression as a means of altering cell fates and generating dominant phenotypes 显示文摘 | BRAND A H PERRIMON N | 1993 | Development1993，118，： | 1 |
| 18 | Brief report: cognitive functioning in children with Tourette's syndrome with and without comorbid ADHD 显示文摘 | Brand N Geenen R Oudenhoven M | 2002 | J Pediatr Psychol2002，27，2： | 1 |
| 19 | Down-regulation of IL-12 by topical corticosteroids in chronic atopic dermatitis显示文摘 | Yawalkar N Karlen S Egli F Brand CU Graber HU Pichler WJ | 2000 | J Allergy Clin Immunol2000，106，5： | 1 |
| 20 | Clenbuterol in- duces cardiac myocyte hypertrophy via paracrine signalling and fibroblast-derived IGF-1 显示文摘 | Bhavsar PK Brand N J Felkin LE | 2010 | J Cardiovasc Transl Res2010，3，6： | 1 |
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