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| 1 | Bone marrow-derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion显示文摘Xerostomia is a severe side effect of radiation therapy in head and neck cancer patients. To date, no satisfactory treatment option has been established. Because mesenchymal stem cells(MSCs) have been identified as a potential treatment modality, we aimed to evaluate stem cell distribution following intravenous and intraglandular injections using a surgical model of salivary gland damage and to analyse the effects of MSC injections on the recruitment of immune cells. The submandibular gland ducts of rats were surgically ligated. Syngeneic adult MSCs were isolated, immortalised by simian virus 40(SV40) large T antigen and characterized by flow cytometry. MSCs were injected intravenously and intraglandularly. After 1, 3 and 7 days, the organs of interest were analysed for stem cell recruitment. Inflammation was analysed by immunohistochemical staining. We were able to demonstrate that, after intravenous injection, MSCs were recruited to normal and damaged submandibular glands on days 1, 3 and 7. Unexpectedly, stem cells were recruited to ligated and non-ligated glands in a comparable manner. After intraglandular injection of MSCs into ligated glands, the presence of MSCs, leucocytes and macrophages was enhanced, compared to intravenous injection of stem cells. Our data suggest that injected MSCs were retained within the inflamed glands, could become activated and subsequently recruited leucocytes to the sites of tissue damage. | Silke Schwarz Ralf Huss Michaela Schulz-Siegmund Breda Vogel Sven Brandau Stephan Lang Nicole Rotter | 2014 | International Journal of Oral Science2014，6，3： | 5 |
| 2 | Activation of natural killer cells by Bacillus Calmette-Guerin显示文摘 | Brandau S Bohle A | 2001 | Eur Urol2001，39，5： | 1 |
| 3 | Immune mechanisms in bacillus Calmette-Guerin immunotherapy for superficial bladder cancer显示文摘 | B{:HLE A BRANDAU S | 2003 | J Urol2003，170，3： | 1 |
| 4 | HMGB1 is overexpressed in tumor cells and promotes activity of regulatory T cells in patients with head and neck cancer显示文摘 | Wild CA Brandau S Lotfi R | 2012 | Oral Oncol2012，48，5： | 1 |
| 5 | Tumor associated macrophages:predicting bacil-lus Calmette-Guerin immunotherapy outcomes显示文摘 | BRANDAU S | 2009 | J Urol2009，181，4： | 1 |
| 6 | Local and systemic immune suppression in blad-der cancer显示文摘 | BRANDAU S | 2007 | J Urol2007，177，1： | 1 |
| 7 | Amniotic fluid stem cell-based models to study the effects of gene mutations and toxicants on male germ cell formation显示文摘男不孕是缺点主要在细菌房间开发引起的一个主要公共健康问题。在过去,精子发生的基因规定上以及在否定环境影响上的研究被人的细菌房间开发是难处理的在 vivo 指导分析的事实妨碍了。与包括鼠标的模型有机体相比,在人的细菌房间开发的分子的进程有基本差别。因此,一在里面 vitro 模型 mimicking 人精子形成将是一个极其珍贵的研究工具。在最近的过去,两个人的胚胎的茎(ES ) 房间和导致的 pluripotent,茎(iPS ) 房间向港口被汇报了区分进初发的细菌房间和配偶子的潜力。我们这里讨论可能性使用人的羊膜的液体是的茎(AFS ) 细胞一个生物模型。自从他们在 2003 的发现, AFS 房间被描绘了区分进所有三细菌层的房间,以有一个高 proliferative 潜力并且是 non-tumourigenic,到 genomically 稳定。另外, AFS 房间不道德的担心是易于的。与 iPS 房间相对照, AFS 房间不需要 pluripotency 的宫外的正式就职,它经常与来源房间的仅仅不完美地清除的 epigenetic 记忆被联系。因为 AFS 房间能与引起疾病的变化从羊水诊断被导出并且能是有高效率的 transfected,他们能在为精子发生探查基因功能并且在为男繁殖毒性屏蔽被使用。 | Claudia Gundacker Helmut Dolznig Mario Mikula Margit Rosner Oliver Brandau Markus Hengstschlager | 2012 | Asian Journal of Andrology2012，14，2： | 1 |
| 8 | Effect mechanism of intravesical BCG immunotherapy of superficial bladder cancer显示文摘 | Bohle A Suttmann H Brandau S | 2006 | Urologe A2006，45，5： | 1 |
| 9 | Epstein-Barr virus-negative boys with non-Hodgkin lymphoma are mutated in the SH2D1A gene,as are patients with X-linked lymphoproliferative disease(XLP)显示文摘 | Brandau O Schuster V Weiss M | 1999 | Hum Mol Genet1999，8，13： | 1 |
| 10 | Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene显示文摘 | Coffey AJ Brooksbank RA Brandau O | 1998 | Nat Genet1998，20，2： | 1 |
| 11 | Immune mechanisms in bacillus Calmette -Guerin immunotherapy for superficial bladder Cancer 显示文摘 | Bohle A Brandau S | 2003 | Urol2003，170，3： | 1 |
| 12 | Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene显示文摘 | Coffey A J Brooksbank RA Brandau O | 1998 | Nat Genet1998，20，2： | 1 |
| 13 | Immune mechanisms in bacillus Chalmette-Guerin immunotherapy for superficial bladder cancer显示文摘 | Bohle A Brandau S | 2003 | J Urol2003，170，3： | 1 |
| 14 | NK cells are essential for effective BCG immunotherapy显示文摘 | Brandau S Riemensberger J Jacobsen M | 2001 | Int J Cancer2001，92，5： | 1 |
| 15 | Toll-like Receptors in Regulatory T Cells of Patients With Head and Neck Cancer 显示文摘 | Wild CA Brandau S Lindemann M | 2010 | Arch Otolaryngol Head Neck Surg2010，136，12： | 1 |
| 16 | The complete form of X- linked congenital stationary night blindness is caused by muta- tions in a gene encoding a leucine-rich repeat protein显示文摘 | Pusch CM Zeitz C Brandau O | 2000 | Na- ture Genetics2000，26，3： | 1 |
| 17 | X-linked retinitis pigmentosa: RPGR mutations in most families with definite X linkage and clustering of mutations in a short sequence stretch of exon ORF15 显示文摘 | Bader I Brandau O Achatz H Apfelstedt-Sylla E Hergers-berg M Lorenz B | 2003 | Invest Ophthalmol Vis Sci2003，44，4： | 1 |
| 18 | X-linked retinitis pigmentosa: RPGR mutations in most families with definite X linkage and clustering of mutations in a short sequence stretch of exon ORF15 显示文摘 | Bader I Brandau O Achatz H | 2003 | Invest Ophthalmol Vis Sci2003，44，4： | 1 |
| 19 | X-linked Retinitis Pigmentosa:RPGR Mutations in Most Families with Definite X Linkage and Clustering of Mutations in a Short Sequence Stretch of Exon ORFl5显示文摘 | BRANDAU O ACHATZ H | 2003 | Invest Ophthalmol Vis Sci2003，44，4： | 1 |
| 20 | HMGB1 is overexpressed in tumor cells and promotes activity of regulatory T cells in patients with head and neck cancer显示文摘 | Wild C A Brandau S Lotfi R | | 0，，05： | 1 |
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