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| 1 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 2 | Robust methods for partial least squares regression显示文摘 | Hubert M Branden K V | 2003 | Journal of Chemometrics2003，17，： | 1 |
| 3 | Tripto lide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506显示文摘 | Chen MA Kohlmeier E Branden M | 1999 | Phytother Res1999，13，： | 1 |
| 4 | A prospective study of a total material of lung cancer from a county in Sweden 1997 - 1999: gender,symptoms, type, stage, and smoking habits显示文摘 | Hillerdal G Branden E | 2002 | Lung Cancer2002，36，1： | 1 |
| 5 | In vivo nuclear delivery of oligonucleotides via hybridizing bifunctional peptides显示文摘 | Christensson B Smith CI | 2001 | Gene Ther2001，8，1： | 1 |
| 6 | The human drug metabolizing cytochrome P450显示文摘 | Wrighton SA Van der Branden M Ring BJ | 1996 | J Pharmacokinet Biopharm1996，24，5： | 1 |
| 7 | Preliminary crystsllographic data for glycolate oxiclase from spinach显示文摘 | LINDQVIST Y BRANDEN C I | 1979 | J Biol Chem1979，154，： | 1 |
| 8 | Chronic Chlamydia pneumoniae infection is a risk factor for the development of COPD显示文摘 | Branden E Koyi H Gnarpe J | | 0，，01： | 1 |
| 9 | Effects of negotiation on language learners' output 显示文摘 | Branden V D K | 1997 | Language Learning1997，，47： | 1 |
| 10 | Structural and functional similarities within the coeuzyme binding domains of dehydrogenases显示文摘 | OHLSSON I NORDSTROM B BRANDEN C I | 1974 | J Mol Biol1974，89，2： | 1 |
| 11 | Safety of abciximab retreatment 显示文摘 | Tcheng J E Kereiakes DJ Branden HC | 1998 | Circulation1998，，： | 1 |
| 12 | Epidemiology of pertussis in children of Flanders Belgium: can healthcare professionals be involved in the infection? 显示文摘 | Mahieu L De Schrijver K Van den Branden D | 2014 | Acta Clin Belg2014，69，2： | 1 |
| 13 | Preliminary crystallographic data for glycolate oxidase from spinach显示文摘 | Branden C-I | 1979 | J Biol Chem1979，254，： | 1 |
| 14 | Chronic Chlamydia pneumoniae infection is a risk factor for the development of COPD显示文摘 | Branden E Koyi H Gnarpe J | | 0，，01： | 1 |
| 15 | BTKbase, mutation database for X-linked agammaglobulinemia (XLA)显示文摘 | Vihinen M Brandau O Branden LJ | 1998 | Nucleic Acids Res1998，26，1： | 1 |
| 16 | The active site of spinach glycolate oxidase显示文摘 | Branden C I | 1989 | J Biol Chem1989，264，： | 1 |
| 17 | Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506显示文摘 | MA Chan JE Kohlmeier M Branden | 1999 | Phytother Res1999，13，6： | 1 |
| 18 | Selenium and Lactobacillius species显示文摘 | Calomme MR Van den Branden K Vanden Berghe D A | 1995 | Journal of Applied Bacteriology1995，79，： | 1 |
| 19 | Early statin treatment prior to primary PCI for acute myocardial infarction:REPERATOR, a randomized placebo-controlled pilot trial显示文摘 | Post S Post MC van den Branden BJ | 2012 | Catheter Cardiovasc Interv2012，80，5： | 1 |
| 20 | Nitrous oxide emission following urea-N fertilization of wetland rice显示文摘 | Smith C J Branden M Patrick Jr W H | 1982 | Soil Sci Plant Natr1982，28，： | 1 |
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