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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Fluorescence and SEM correlative microscopy for nanomanipulation of subcellular structures显示文摘Nanomanipulation under scanning electron microscopy(SEM)enables direct interactions of a tool with a sample.We recently developed a nanomanipulation technique for the extraction and identification of DNA contained within sub-nuclear locations of a single cell nucleus.In nanomanipulation of sub-cellular structures,a key step is to identify targets of interest through correlating fluorescence and SEM images.The DNA extraction task must be conducted with low accelerating voltages resulting in low imaging resolutions.This is imposed by the necessity of preserving the biochemical integrity of the sample.Such poor imaging conditions make the identification of nanometer-sized fiducial marks difficult.This paper presents an affine scale-invariant feature transform(ASIFT)based method for correlating SEM images and fluorescence microscopy images.The performance of the image correlation approach under different noise levels and imaging magnifications was quantitatively evaluated.The optimal mean absolute error(MAE)of correlation results is 68634 nm under standard conditions.Compared with manual correlation by skilled operators,the automated correlation approach demonstrates a speed that is higher by an order of magnitude.With the SEM-fluorescence image correlation approach,targeted DNA was successfully extracted via nanomanipulation under SEM conditions. | Zheng Gong Brandon K Chen Jun Liu Chao Zhou Dave Anchel Xiao Li Ji Ge David P Bazett-Jones Yu Sun | 2014 | Light(Science & Applications)2014，3，1： | 2 |
| 3 | Validation of a sensitive LC-MS/MS method for the determination of zidovudine and lamivudine in human plasma显示文摘 | JOSEPH E R BRANDON K LANE R B | 2012 | Biomed Chromatogr2012，26，1： | 1 |
| 4 | Conservingtropical biodiversity amid weak institutions 显示文摘 | Barrett C B Brandon K Gibson C Gjertsen H | 2001 | BioScience2001，51，6： | 1 |
| 5 | Differential diagnosis and treatment of iliotibial band pain secondary to a hypomobile cuboid in a 24-year-old female tri- atblete显示文摘 | Brandon K Patla C | 2013 | J Man Manip rher2013，21，3： | 1 |
| 6 | Effectiveness of no sting skin protectant and aquaphor on water loss and skin integrity in premature infants显示文摘 | Brandon DH Coe K Hudson-Barr D | 2010 | J Perinatol2010，30，6： | 1 |
| 7 | Com- parison of plasticity in vivo and in vitro in the developing vi- sual cortex of normal and protein kinase A RI/3-deficient mice显示文摘 | HENSCH T K GORDON J A BRANDON E P | 1998 | The Journal of Neuroscience1998，18，6： | 1 |
| 8 | Motions or muscles Some behavioral factors underlying robotic assistance of motor recovery显示文摘 | Neville H Hermano I K Brandon | 2006 | The Journal of Rehabilitation Research & Development2006，43，5： | 1 |
| 9 | Genetic and environmental influences on blood pressure and pulse pressure among adult African Americans显示文摘 | BRANDON D T WHITWELD K E SOLLERS J J 3rd | 2003 | Ethn Dis2003，13，： | 1 |
| 10 | On the effects of variations in the design parameters on the dynamic performance of machine tool spindle-bearing systems显示文摘 | AL-SHAREEF K J H BRANDON J A | 1990 | International Journal of Machine Tools & Manufacture1990，30，3： | 1 |
| 11 | Late Cenozoic exhumation of the Cascadia accretionary wedge in the Olympic Mountains,northwest Washington State显示文摘 | Brandon M T Roden-Tice M K Garver J I | 1998 | Geological Society of America Bulletin1998，110，8： | 1 |
| 12 | The Mechanism of transfer of immunoglobulins into mammary Secretion of cows显示文摘 | BRANDON M R WATSON D L LASCELLES A K | 1971 | Aust J Exp Biol Med Sci1971，49，： | 1 |
| 13 | The principles and practice of buffer zones and local participation in biodiversity conservation显示文摘 | WELLS M P BRANDON K E | | 0，，： | 1 |
| 14 | Synthesis and physical properties of estolides from lesquerella and castor fatty acid esters 显示文摘 | Cermak S C Brandon K B Isbell T A | 2006 | Industrial Crops and Products2006，23，1： | 1 |
| 15 | The principles and practice of bufferzones and local participation in biodiversity conservation显示文摘 | Wells M P Brandon K E | 1993 | Ambio1993，22，23： | 1 |
| 16 | Use of direct-acting antiviral agents in hepatitis C virusinfected liver transplant candidates显示文摘Since the advent of direct acting antiviral(DAA) agents, chronic hepatitis C virus(HCV) treatment has evolved at a rapid pace. In contrast to prior regimen involving ribavirin and pegylated interferon, these newer agents are highly effective, well-tolerated, have shorter course of therapy and safer essentially in all HCV patients including those with advanced liver disease and following liver transplantation. Clinicians caring for HCV-infected patients on the liver transplant(LT) waitlist are often faced with a dilemma whether to treat HCV infection before or after liver transplantation. Sustained virological response(SVR) rates following HCV treatment may improve hepatic function sufficiently enough to negate the need for LT in certain patients. On the other hand, the decrease in MELD without improvement in quality of life in certain patients may lead to delay or dropout from potentially curative LT surgery list. In this context, our review focuses on the approach to and optimal timing of DAA-based treatment of HCV infection in LT candidates in the peri-transplant period. | Chiranjeevi Gadiparthi George Cholankeril Brandon J Perumpail Eric R Yoo Sanjaya K Satapathy Satheesh Nair Aijaz Ahmed | 2018 | World Journal of Gastroenterology2018，24，3： | 1 |
| 17 | Global conservation of biodiversity and ecosystem services显示文摘 | Turner W R Brandon K Brooks T M | 2007 | Bio Science2007，57，10： | 1 |
| 18 | New refinements of T brass type structure Cu5Zn5, Cu5Cd8 and Fe3Zn10 显示文摘 | BRANDON J K BRIZARD R Y CHIEH P C | 1974 | Acta Cryst1974，30，： | 1 |
| 19 | Optimization Strategies for Machine Tool Spindle-hearing System: a Critical Review显示文摘 | Brandon J A A1-Sharer K J H | 1992 | Journal of Engineering for In- dustry1992，114，3： | 1 |
| 20 | Single-nucleotide polymorphisms in porcine mannan-binding lectin A显示文摘 | Brandon N L Natalie D K Squires E J | 2006 | Immunogenetics2006，58，12： | 1 |
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