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| 1 | Comparative effectiveness of traditional chemoembolization with or without sorafenib for hepatocellular carcinoma显示文摘AIM: To compare the overall survival (OS) and progression-free survival (PFS) with associated adverse events (AE) in patients with unresectable hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) + sorafenib vs TACE alone. METHODS: In this retrospective cohort study we collected data on all consecutive patients with a diagnosis of unresectable HCC between 2007 and 2011 who had been treated with TACE + sorafenib or TACE alone. We hypothesized that the combination therapy is superior to TACE alone in improving the survival in these patients. Data extracted included patient's demographics, etiology of liver disease, histology of HCC, stage of liver disease with respect to model of end stage liverdisease score and Child-Turcotte-Pugh (CTP) classification and Barcelona Clinic Liver Cancer (BCLC) staging for HCC. Computed tomography scan findings, alpha fetoprotein levels, number of treatments and related AE were also recorded and analyzed. RESULTS: Of the 43 patients who met inclusion criteria, 13 were treated with TACE + sorafenib and 30 with TACE alone. There was no significant difference in median survival: 20.6 mo (95%CI: 13.4-38.4) for the TACE + sorafenib and 18.3 mo (95%CI: 11.8-32.9) for the TACE alone (P = 0.72). There were also no statistically significant differences between groups in OS (HR = 0.82, 95%CI: 0.38-1.77; P = 0.61), PFS (HR = 0.93, 95%CI: 0.45-1.89; P = 0.83), and treatment-related toxicities (P = 0.554). CTP classification and BCLC staging for HCC were statistically significant (P = 0.001, P = 0.04 respectively) in predicting the survival in patients with HCC. The common AE observed were abdominal pain, nausea, vomiting and mild elevation of liver enzymes. CONCLUSION: Combination therapy with TACE + sorafenib is safe and equally effective as TACE alone in patients with unresectable HCC. CTP classification and BCLC staging were the significant predictors of survival. Future trials with large number of patients are needed to further validate this observation. | Adnan Muhammad Manish Dhamija Gitanjali Vidyarthi Donald Amodeo William Boyd Branko Miladinovic Ambuj Kumar | 2013 | World Journal of Hepatology2013，5，7： | 16 |
| 2 | Primary colorectal lymphoma:An overview显示文摘Lymphomas represent common hematological malignancies with increasing incidence in recent years.The major site of extranodal non-Hodgkin lymphoma is the gastrointestinal tract.Involvement of the large intestine is rare in comparison to the stomach or small bowel.The disease appears later in life,predominantly in the male population.Complaints are nonspecific,requiring a high index of suspicion in order to establish the diagnosis.The treatment varies from chemotherapy alone to multimodal therapies combining surgery,chemotherapy and radiotherapy.The small number of patients with various histological subtypes and different stage at presentation results in unclear protocol for the treatment of primary colorectal lymphoma.The purpose of this paper is to review current data on primary lymphoma of the colon and rectum while analyzing reported case series and published material on the subject. | Goran Z Stanojevic Milica D Nestorovic Branko R Brankovic Miroslav P Stojanovic Milan M Jovanovic Milan D Radojkovic | 2011 | World Journal of Gastrointestinal Oncology2011，3，1： | 15 |
| 3 | 既有建筑采用可再生能源节能改造技术分析显示文摘以济南市某公共建筑为对象,以《公共建筑节能设计标准》为依据,并借鉴瑞典进行既有建筑节能改造的成功技术和经验,基于节能、降耗及减排的原则,以应用可再生能源为技术手段,对该建筑进行了节能改造设计。针对不同采用可再生能源的节能技术改造方案所带来的节能效益进行了对比,给出了采用不同节能技术对既有建筑改造的初投资及其回收期的经济分析,对推动既有建筑节能改造具有借鉴作用。 | 赵忠超 Branko Simanic 程林 | 2009 | 建筑经济2009，30，2： | 8 |
| 4 | Minimally invasive procedures on the lumbar spine显示文摘Degenerative disease of the lumbar spine is a common and increasingly prevalent condition that is often implicated as the primary reason for chronic low back pain and the leading cause of disability in the western world. Surgical management of lumbar degenerative disease has historically been approached by way of open surgical procedures aimed at decompressing and/or stabilizing the lumbar spine. Advances in technology andsurgical instrumentation have led to minimally invasive surgical techniques being developed and increasingly used in the treatment of lumbar degenerative disease. Compared to the traditional open spine surgery, minimally invasive techniques require smaller incisions and decrease approach-related morbidity by avoiding muscle crush injury by self-retaining retractors, preventing the disruption of tendon attachment sites of important muscles at the spinous processes, using known anatomic neurovascular and muscle planes, and minimizing collateral soft-tissue injury by limiting the width of the surgical corridor. The theoretical benefits of minimally invasive surgery over traditional open surgery include reduced blood loss, decreased postoperative pain and narcotics use, shorter hospital length of stay, faster recover and quicker return to work and normal activity. This paper describes the different minimally invasive techniques that are currently available for the treatment of degenerative disease of the lumbar spine. | Branko Skovrlj Jeffrey Gilligan Holt S Cutler Sheeraz A Qureshi | 2015 | World Journal of Clinical Cases2015，3，1： | 8 |
| 5 | The pathologic relevance of metabolic criteria in patients with biopsy-proven nonalcoholic fatty liver disease and metabolic dysfunction associated fatty liver disease:A multicenter cross-sectional study in China显示文摘Background:This study aimed to assess the association between metabolic syndrome(Met S)and severity of nonalcoholic fatty liver disease(NAFLD),and to discuss the pathological relevance of the diagnostic criteria in metabolic(dysfunction)associated fatty liver disease(MAFLD).Methods:This was a multicenter,cross-sectional study.Patients with NAFLD confirmed by liver biopsy were enrolled between July 2016 and December 2018 from 14 centers across the mainland of China.Anthropometric and metabolic parameters were collected to assess the pathological relevance.Results:Of 246 enrolled patients with NAFLD,150(61.0%)had the comorbidity of Met S.With the increase of metabolic components,the proportions of nonalcoholic steatohepatitis(NASH)and significant fibrosis were notably increased.The comorbid three metabolic components significantly increased the proportion of NASH,and further increase of metabolic components did not increase the proportion of NASH.However,the increase of metabolic components was parallel to the increase of the proportion of liver fibrosis.Among the 246 patients,239(97.2%)met the diagnostic criteria of MAFLD.Although non-MAFLD patients had less NASH,they present with similar proportion of significant fibrosis and cirrhosis.In the diagnostic criteria of MAFLD,BMI≥23 kg/m2 was related to NASH(Mantel-Haenszel Common Estimate OR:2.975;95%CI:1.037–8.538;P=0.043),and T2 DM was related to significant fibrosis(Mantel-Haenszel Common Estimate OR:2.531;95%CI:1.388–4.613;P=0.002).The homeostasis model assessment of insulin resistance(HOMA-IR)≥2.5 was the most significant factor for NASH(OR:4.100;95%CI:1.772–9.487;P=0.001)and significant factor for liver fibrosis(OR:2.947;95%CI:1.398–6.210;P=0.004)after the adjustments of the BMI and diabetes.Conclusions:Metabolic dysregulations are important risk factors in NAFLD progression.The insulin resistance status may play a predominant role in the progression in MAFLD patients. | Rui-Xu Yang Zheng-Sheng Zou Bi-Hui Zhong Hong Deng Fang-Ping He Jun-Ping Shi Cai-Yan Zhao Yu-Qiang Mi Yong-Jian Zhou Fu-Sheng Di Rui-Dan Zheng Qin Du Jia Shang Branko Popovic Jin Jun Chen Jian-Gao Fan | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，5： | 5 |
| 6 | Gustilo ⅢB 和ⅢC 高能量胫骨骨折——截肢与保肢的比较显示文摘截肢和保肢患者长期的功能和心理结果相似。如果早期不截肢而采取保肢,就必须考虑到:二期截肢的风险(5%~14%)、潜在的并发症(保肢术通常更高)以及住院时间延长。由于胫骨骨折严重程度不同采取的治疗可能不同(G ustiloⅢC型比ⅢB型更可能截肢),这使得对比很困难,而且相关的队列研究文献很少。 | Ladislav Nagy Branko Kopjar Norbert P.Südkamp 陈国奋 顾立强 | 2005 | 中华创伤骨科杂志2005，7，5： | 4 |
| 7 | 既有建筑被动节能改造技术分析显示文摘以济南市某公共建筑为对象,以《公共建筑节能设计标准》为依据,并借鉴瑞典在进行既有建筑节能改造的成功技术和经验,对济南某建筑进行了被动节能改造设计。针对不同的节能技术改造方案所带来的节能效益进行了对比,给出了采用不同被动节能技术对既有建筑改造的初投资及其回收期的经济分析,对推动既有建筑节能改造具有借鉴作用。 | 赵忠超 Branko Simanic 程林 | 2008 | 建筑节能2008，36，10： | 3 |
| 8 | cytokine 的角色像受体的因素 1 在肝的星形的房间和纤维变性显示文摘 AIM:To elucidate the role of cytokine receptor-like factor 1(CRLF1) in hepatic stellate cells and liver fibrosis.METHODS:Rat hepatic stellate cells(HSCs) were isolated by Nykodenz gradient centrifugation and activated by culturing in vitro.Differentially expressed genes in quiescent and culture activated HSCs were identified using microarrays.Injections of carbon tetrachloride(CCl 4) for 4 wk were employed to induce liver fibrosis.The degree of fibrosis was assessed by Sirius red staining.Adenovirus expressing CRLF1 was injected through tail vein into mice to achieve overexpression of CRLF1 in the liver.The same adenovirus was used to overexpress CRLF1 in quiescent HSCs cultured in vitro.Expression of CRLF1,CLCF1 and ciliary neurotrophic factor receptor(CNTFR) in hepatic stellate cells and fibrotic livers was analyzed by semi-quantitative reverse transcription-polymerase chain reaction and Western blotting.Expression of profibrotic cytokines and collagens was analyzed by the same method.RESULTS:CRLF1 is a secreted cytokine with unknown function.Human mutations suggested a role in development of autonomous nervous system and a role of CRLF1 in immune response was implied by its similarity to interleukin(IL)-6.Here we show that expression of CRLF1 was undetectable in quiescent HSCs and was highly upregulated in activated HSCs.Likewise,expression of CRLF1 was very low in normal livers,but was highly upregulated in fibrotic livers,where its expression correlated with the degree of fibrosis.A cofactor of CLRF1,cardiotrophin-like cytokine factor 1(CLCF1),and the receptor which binds CRLF1/CLCF1 dimer,the CNTFR,were expressed to similar levels in quiescent and activated HSCs and in normal and fibrotic livers,indicating a constitutive expression.Overexpression of CLRF1 alone in the normal liver did not stimulate expression of profibrotic cytokines,suggesting that the factor itself is not pro-inflammatory.Ectopic expression in quiescent HSCs,however,retarded their activation into myofibroblasts and specifically decreased expression of type Ⅲ collagen.Inhibition of type Ⅲ collagen expression by CRLF1 was also seen in the whole liver.Our results suggest that CLRF1 is the only component of the CRLF1/CLCF1/CNTFR signaling system that is inducible by a profibrotic stimulus and that activation of this system by CLRF1 may regulate expression of type Ⅲ collagen in fibrosis.CONCLUSION:By regulating activation of HSCs and expression of type Ⅲ collagen,CRLF1 may have an ability to change the composition of extracellular matrix in fibrosis. | Lela Stefanovic Branko Stefanovic | 2012 | World Journal of Hepatology2012，4，12： | 3 |
| 9 | 髋臼骨折——开放复位内固定与全髋关节置换的比较显示文摘病例组研究的结果说明:选择开放复位内固定或全髋关节置换对结果影响不大,但并发症如异位骨化等前者比后者的发生率高。研究人群的不同,尤其是年龄因素,可以单独影响结果。全髋置换的研究人群年龄大于开放复位内固定者,这使得关于更佳方法的结论不具有可行性。还需要随机对照试验提供更具有说服力的证据。 | David Ring Rodrigo F.Pesantez Branko Kopjar 陈国奋 顾立强 | 2005 | 中华创伤骨科杂志2005，7，3： | 3 |
| 10 | 改性十六烷基甜菜碱表面活性剂在个人护理品中的应用显示文摘开发了一种温和的源自天然原料的表面活性剂。它能够与各种水溶助长性表面活性剂复配并有效地提高护发和护肤产品的温和性、黏度及发泡性。 | Susan X M Dong Branko Sajic Anatoly Dameshek 谢文炳 | 2012 | 日用化学品科学2012，35，2： | 3 |
| 11 | Perioperative outcomes in minimally invasive lumbar spine surgery: A systematic review显示文摘AIM: To compare minimally invasive(MIS) and open techniques for MIS lumbar laminectomy, direct lateral and transforaminal lumbar interbody fusion(TLIF) surgeries with respect to length of surgery, estimated blood loss(EBL), neurologic complications, perioperative transfusion, postoperative pain, postoperative narcotic use, and length of stay(LOS).METHODS: A systematic review of previously published studies accessible through Pub Med was performed. Only articles in English journals or published with English language translations were included. Level of evidence of the selected articles was assessed. Statistical data was calculated with analysis of variance with P < 0.05 considered statistically significant.RESULTS: A total of 11 pertinent laminectomy studies, 20 direct lateral studies, and 27 TLIF studies were found. For laminectomy, MIS techniques resulted in a significantly longer length of surgery(177.5 min vs 129.0 min, P = 0.04), shorter LOS(4.3 d vs 5.3 d, P = 0.01) and less perioperative pain(visual analog scale: 16 ± 17 vs 34 ± 31, P = 0.04). There is evidence of decreased narcotic use for MIS patients(postoperative intravenous morphine use: 9.3 mg vs 42.8 mg), however this difference is of unknown significance. Direct lateral approaches have insufficient comparative data to establish relative perioperative outcomes. MIS TLIF had superior EBL(352 mL vs 580 mL, P < 0.0001) and LOS(7.7 d vs 10.4 d, P < 0.0001) and limited data to suggest lower perioperative pain.CONCLUSION: Based on perioperative outcomes data, MIS approach is superior to open approach for TLIF. For laminectomy, MIS and open approaches can be chosen based on surgeon preference. For lateral approaches, there is insufficient evidence to find noninferior perioperative outcomes at this time. | Branko Skovrlj Patrick Belton Hekmat Zarzour Sheeraz A Qureshi | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 12 | Lisfranc关节损伤——切开复位内固定术与Ⅰ期跗趾关节融合术的比较显示文摘两个小样本对照试验得到的证据尚不足以说明,在Lisfranc关节损伤时,切开复位内固定术(ORIF)的治疗效果要优于Ⅰ期跗趾关节融合术。在一项小样本的随机对照研究中发现,当患者合并有原发性Lisfranc韧带损伤时,与跗趾关节融合术相比,采用ORIF治疗的功能评价结果和疼痛评分会更差,而且常常要施加额外的手术治疗。 | Beate Hanson Branko Kopjar | 2008 | 中华创伤骨科杂志2008，10，12： | 2 |
| 13 | Analysis of the CAG repeat number in exon 1 of the androgen receptor gene in Slovene men with idiopathic azoospermia and oligoasthenoteratozoospermia显示文摘 | Borut Peterlin Branko Zorn Natasa Teran Tanja Kunej | 2007 | Asian Journal of Andrology2007，9，2： | 2 |
| 14 | Evidence for a Long-Term Strength Threshold in Crystalline Rock显示文摘 | Branko Damjanac Charles Fairhurst | 2010 | Rock Mechanics and Rock Engineering2010，，5： | 2 |
| 15 | Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4显示文摘 | Jennifer Nichols Branko Zevnik Konstantinos Anastassiadis Hitoshi Niwa Daniela Klewe-Nebenius Ian Chambers Hans Sch?ler Austin Smith | 1998 | Cell1998，，3： | 2 |
| 16 | 桡骨远端骨折显示文摘根据四项回顾性队列研究的结论,目前尚不能推断在治疗桡骨远端骨折时,是采用背侧钢板固定有利还是采用掌侧钢板固定有利。研究认为采用背侧钢板固定更有利于掌倾角的恢复,但是,总体上两种固定方法在其他影像学表现和功能活动度评价方面没有显著性差异。采用背侧钢板固定的患者屈伸活动似乎有少许丢失,但是并没有对两种固定方法在这方面进行比较分析的研究。在所有的研究中,选择何种固定方法主要取决于外科医生的判断,因此关于预后的比较就难免会出现偏倚。 | Branko Kopjar 王簕(译) 杨云峰(译) | 2009 | 中华创伤骨科杂志2009，11，10： | 2 |
| 17 | Turbulent heat transfer with phase change material suspensions显示文摘 | Sanjay K Roy Branko L Avanic | 2001 | International Journal of Heat and Mass Transfer2001，，12： | 2 |
| 18 | A posterior versus anterior surgical approach in combination with debridement, interbody autografting and instrumentation for thoracic and lumbar tuberculosis显示文摘 | Xiaobing Pu Qiang Zhou Qinyi He Fei Dai Jianzhong Xu Zehua Zhang Kopjar Branko | 2012 | International Orthopaedics2012，，2： | 2 |
| 19 | 十五肽BPC157减弱慢性苯丙胺诱导的行为障碍(英文)显示文摘AIM: To investigate the effect of pentadecapeptide BPC 157 on chronic exposure to amphetamine in rats, particularly the changes commonly referred in chronic amphetamine studies as tolerance ( lesser grade of stereotyped behavior, without increased excitability) and reverse tolerance (ie, prominent stereotyped behavior and heightened startle response upon late amphetamine challenges). METHODS: After initial application (initial single dose-regimen), amphetamine (10 mg/kg, ip) was given once daily till d 5 ( continuous administration-regimen), and thereafter on d 8, 16, and 46 (intermittent administration regimen). For stereotyped behavior and heightened startle response the observation period was 120 min after amphetamine application, and each animal was observed for 10 s in 5 min intervals. Pentadecapeptide BPC 157 (10 μg/kg or 10 ng/kg, ip) or saline (5.0 mL/kg, ip) were given only at the beginning of the experiment, simultaneously with the initial dose of amphetamine. RESULTS: In relation to | Predrag SIKIRIC, Nikola JELOVAC, Andjelka JELOVAC-GJELDUM, Goran DODIG, Mario STARESINIC, Tornislav ANIC, Ivan ZORICIC, Davor RAK, Darko PEROVIC, Gorana ARALICA, Gojko BULJAT, Ingrid PRKACEV, Martina LOVRIC-BENCIC, Jadranka SEPAROVIC, Sven SEIWERTH, Rudolf RUCMAN, Marijan PETEK, Branko TURKOVIC, Tihomil ZIGER, AJenka BOBAN-BLAGAIC, Vlado BEDEKOVIC, Ante TONKIC, Slaven BABIC ( Department of Pharmacology, Medical Faculty University of Zagreb, Croatia) | 2002 | Acta Pharmacologica Sinica2002，23，5： | 2 |
| 20 | Reduction of heterocyclic diazo compounds with titanium( Ⅲ ) and iron ( Ⅱ ) salts 显示文摘 | BRANKO S MIHA T MARJAN K | 1979 | Synthesis1979，，3： | 1 |
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