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| 1 | Excimer laser surgery of the cornea显示文摘 | Trokel SL Srinivasan R Braren B | 1983 | Am J Ophthalmol1983，96，6： | 1 |
| 2 | Excimer laser surgery of the cornea显示文摘 | Trokel S L Srinivasan R Braren B | 1983 | Am J Ophthalmol1983，96，： | 1 |
| 3 | Excimer laser surgery of the cor-nea显示文摘 | Trokel SL Srinivasan R Braren B | 1983 | Am J Ophthalmol1983，96，： | 1 |
| 4 | Direct imaging of the fragments produced during excimer laser ablation of YBa2Cu3O7-x显示文摘 | Gupta A Braren B Casey K G | 1991 | Appl Phys Lett1991，59，： | 1 |
| 5 | Ultraviolet laser ablation of organic polymers 显示文摘 | Srinivasan R Braren B | 1989 | Chemical Review1989，89，6： | 1 |
| 6 | Excimer laser surgery of the cornea显示文摘 | Trokel SL Srinivasan R Braren B | 1983 | Am J Ophthalmol1983，96，： | 1 |
| 7 | Excimer laser surgery of the cornea显示文摘 | Srinivasan R Braren B | 1983 | Am J Ophthalmol1983，96，6： | 1 |
| 8 | Excimer laser surgery, of the cornea显示文摘 | Trokel SL Srinivasan R Braren B | 1983 | Am J Ophthalmol1983，96，： | 1 |
| 9 | Excimer laser surgery of the cornea显示文摘 | Trokel SL Srinivasan R Braren B | 1983 | Am J Ophthalmol1983，96，6： | 1 |
| 10 | On the direct observation of the gas-dynamics of laser-pulse sputtering of polymers显示文摘 | KELLY R BRAREN B | 1991 | Appl Phys B1991，53，： | 1 |
| 11 | Excimer laser surgery of the cornea显示文摘 | Trokel SL Srinivasan R Braren B | 1983 | Am J Ophthalmol1983，96，6： | 1 |
| 12 | Excimer laser surgery of the cornea显示文摘 | Trokel SL Srinivasan R Braren B | 1983 | Am J Ophthalmol1983，96，6： | 1 |
| 13 | High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy显示文摘BACKGROUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation therapy.Due to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor growth.Transarterial chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in LT.However,it remains unclear if one of those treatment options is superior.The analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by histopathology.AIM To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT alone.METHODS In this multicenter retrospective study,27 patients who received liver transplantation for HCC were analyzed.Patients received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver transplantation.Liver explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging therapies.Statistical analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and Mann-Whitney-U tests.RESULTS Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and SBRT.There were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor lesions.Strikingly,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P value<0.001).CONCLUSION Our data suggests that a combination of TACE and SBRT increases the rate of complete histopathological response compared to TACE or SBRT alone in bridging to liver transplantation. | Ulrike Bauer Sabine Gerum Falk Roeder Stefan Münch Stephanie E Combs Alexander B Philipp Enrico N De Toni Martha M Kirstein Arndt Vogel Carolin Mogler Bernhard Haller Jens Neumann Rickmer F Braren Marcus R Makowski Philipp Paprottka Markus Guba Fabian Geisler Roland M Schmid Andreas Umgelter Ursula Ehmer | 2021 | World Journal of Gastroenterology2021，27，24： | 1 |
| 14 | Excimer laser surgery of the cornea显示文摘 | Srinivasan R Braren B | | Am J Ophthalmol0，96，6： | 1 |
| 15 | Laser-assisted seeding for electroless plating on polyimide surface 显示文摘 | Schrott A G Braren B O'Sullivan E J M | 1995 | Journal of Electrochemistry Society1995，142，3： | 1 |
| 16 | Direct imaging of the fragments produced during excimer laser ablation of YBa2Cu3O7-X显示文摘 | Gupta A Braren B Casey K G | 1991 | Appl Phys Lett1991，59，： | 1 |
| 17 | Excimer laser surgery of the cornea显示文摘 | Trokel SL Srinivasan R Braren B | 1983 | Am J Ophthalmol1983，96，6： | 1 |
| 18 | Excimer laser surgery of cornea 显示文摘 | Trokel SL Srinivasan R Braren B | 1983 | Am J Ophthalmol1983，96，6： | 1 |
| 19 | Excimer laser surgery of the cornea显示文摘 | Trokel SL Srinivasan R Braren B | 1983 | Am J Ophthalmol1983，96，： | 1 |
| 20 | Excimer laser surgery of the cornea 显示文摘 | Trokel SL Srinlvasen R Braren B | 1983 | Am J Ophtalmal1983，96，6： | 1 |
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