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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | The NLANR network analysis infrastructure 显示文摘 | McGregor T Braun H W Brown J | 2000 | IEEE Communications Magazine2000，38，5： | 2 |
| 3 | Why Is the Climate Forcing of Sulfate Aerosols So Uncertain?显示文摘Sulfate aerosol particles have strong scattering effect on the solar radiation transfer which results in in- creasing the planet albedo and, hence, tend to cool the earth-atmosphere system, Also, aerosols can act as the cloud condensation nuclei (CCN) which tend to increase the albedo of clouds and cool the global warm- ing. The ARPEGE-Climat version 3 AGCM with FMR radiation scheme is used to estimate the direct and indirect radiative forcing of sulfate aerosols. For minimizing the uncertainties in assessing this kind of cool- ing effect, all kinds of factors are analyzed which have been mixed in the assessment process and may lead to the different results of the radiative forcing of aerosols, It is noticed that one of the uncertainties to assess the climate forcing of aerosols by GCM results from the different definition of radiative forcing that was used. In order to clarify this vague idea, the off-line case for considering no feedbacks and on-line case for including all the feedbacks have been used for assessment. The direct forcing of sulfate aerosols in off-line case is -0.57 W/ m2 and -0.38 W / m2 for the clear sky and all sky respectively. The value of on-line case appears to be a little larger than that in off-line case chiefly due to the feedback of clouds. The indirect forc- ing of sulfate aerosols in off line case is -1 .4 W / m2 and -1 .0 W / m2 in on-line case. The radiative forcing of sulfate aerosols has obvious regional characteristics. There is a larger negative radiative forcing over North America, Europe and East Asia. If the direct and indirect forcing are added together, it is enough to offset the positive radiative forcing induced by the greenhouse gases in these regions. | Hu Rongming, Serge Planton, Michel Deque, Pascal Marquet and Alain Braun Centre national de recherches m t orologiques, Meteo-France | 2001 | Advances in Atmospheric Sciences2001，18，6： | 2 |
| 4 | Phosphorylation of key serine residues is required for internalization of the complement 5a(C5a) anaphytoxin receptor via a beta-arrestin,dynamin,and clathrin-dependent pathway显示文摘 | Braun L Chiristophe T Boulay F | 2003 | J Biol Chem2003，278，6： | 2 |
| 5 | A comparison of eleven static heuristics for mapping a class of independent tasks onto heterogeneous distributed computing systems显示文摘 | Braun T D Siegel H S Beck N | 2001 | Journal of Parallel and Distributed Computing2001，61，6： | 1 |
| 6 | HLA-DMA and HLA-DMB alleles in German patients with type I diabetes mellitus显示文摘 | Siegmund T Donner H Braun J | 1999 | Tissue Antigens1999，54，3： | 1 |
| 7 | Elevated soluble tumor necrosis factor receptor serum concentration and short-term mortality in liver cirrhosis without acute infections 显示文摘 | Rrichel C Sudhop T Braun B | 2000 | Digestion2000，62，1： | 1 |
| 8 | Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity显示文摘 | Braun T Schofield PR Sprengel R | 1991 | EMBO J1991，10，7： | 1 |
| 9 | Development andpathology of pulmonary hypertension 显示文摘 | Tuder RM Abman SH Braun T | 2009 | J Am Coll Cardi-ol2009，54，1： | 1 |
| 10 | Auricular reconstruction with porous polyethylene frameworks:outcome and patient benefit in 65 children and adults显示文摘 | Braun T Gratza S Becker S | | 0，，04： | 1 |
| 11 | Near optimal control of cooling tower for chilled water system显示文摘 | Braun J E Diderrich G T | | 0，，02： | 1 |
| 12 | Relative Indicators and Relational Charts for Comparative Assessment of Publication Output and Citation Impact 显示文摘 | Schubert A Braun T | 1986 | Scientometries1986，9，56： | 1 |
| 13 | Catalytic hydrodefluorination of fluoroaromatics with silanes as hydrogen source at a binuclear rhodium complex: Characterization of key interm- ediates显示文摘 | Zgtmostn I Ahrens M Braun T | 2013 | J Fluorine Chem2013，155，： | 1 |
| 14 | Semimature stage : a checkpoint in a dendritic cell maturation program that allows for functional reversion after signal-regulatory protein-alpha ligation and maturation signals显示文摘 | Braun D Galibert L Nakajima T | 2006 | J Immunol2006，177，12： | 1 |
| 15 | A molecular phylogeny of the pheasants and partridges suggests that these lineages are not monophyletic显示文摘 | Kimball R T Braun E T Zwartjes P W | 1999 | Mol Phyl Evol1999，11，： | 1 |
| 16 | Minimizing operating costs of vapor compression equipment with optimal service scheduling 显示文摘 | Rossi T M Braun J E | 1996 | International Journal of Heating Ventilating and Air Conditioning and Refrigerating Research1996，2，1： | 1 |
| 17 | A comparison of eleven static heuristics for mapping a class of independent tasks onto heterogeneous distributed computing systems显示文摘 | BRAUN T D SIEGEL H J BECJ N | 2001 | Journal of Parallel and Distributed Computing2001，61，6： | 1 |
| 18 | A novel method to inject hyaluronic acid: the Fern Pattern Technique 显示文摘 | Van Eijk T Braun M | 2007 | J Drugs Dermatol2007，6，8： | 1 |
| 19 | Elevated soluble tumor necrosis factor receptor serum concentrations and short-term mortality in liver cirrhosis without acute infections 显示文摘 | Reichel C Sudhop T Braun B | 2000 | Digestion2000，62，1： | 1 |
| 20 | Endothelial progenitor cells:new biomarkers and potential therapy in intensive care显示文摘 | SEGUIN T BRAUN T MIRA J P | 2007 | {H}MéDECINE ET MALADIES INFECTIEUSES2007，，06： | 1 |
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